Showing 76–100 of 200 documents
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Shahnawaz Majeed, Safiya Mehraj, Zahoor Ahmad
… per year. Approximately 4,65,000 people fell ill with multidrug or rifampicin-resistant tuberculosis (MDR/RR-TB)/year. This deadly TB scenario demands new TB drug regimens to tackle global infection reservoir, and worldwide spread of drug resistance and DS TB. Successful entry o…
Suman Saurabh, Pankaj Bhardwaj
…mended in special groups such as health workers, prisoners, drug users, homeless persons and immigrants from high TB-burden countries.[1] On the other hand, systematic LTBI testing and TPT has not been recommended among people with diabetes, underweight individuals, tobacco smoke…
Gao Y, Li J, Guo X, Guan L, Wang J, et al.
…pment of AAs for active or latent TB patients infected with drug-sensitive or drug-resistant Mtb.
Zipporah Dery, Celso Pagatpatan, Margel Bonifacio
…nt adherence. The review will include studies that focus on drug-sensitive tuberculosis, drug-resistant tuberculosis, and latent tuberculosis infection, as well as studies on patients with tuberculosis and common comorbidities, such as diabetes or HIV. **METHODS:** This review w…
María Victoria Pinedo, Martín Giorgi, María A Bajo, Borja Quiroga
…l population, short, oral regimens are recommended for both drug-susceptible and drug-resistant TB in eligible individuals; however, there are no formal recommendations on the efficacy and/or safety of these regimens for the treatment of pulmonary tuberculosis in hemodialysis pat…
Madhvi A, Mishra H, Chegou NN, Baker B
…ssion levels of IFITs reduce in vitro survival of different drug-susceptible and drug-resistant mycobacteria and correlates with latent TB infection in infected individuals, hence emerging as an immuno-therapeutic target against M. tb .
Steven M Holland, M.D.
…owever dissemination to almost any other organ is possible. Drug resistance of the organism, co-infection with HIV, and paradoxical reactions upon treatment are all factors that may complicate treatment. Host defense against mycobacterial infections is important. Specific defect…
Grotz E, Tateosian N, Amiano N, Cagel M, Bernabeu E, et al.
… for the last 50 years, the development of multi- and extra-drug-resistant Mycobacterium tuberculosis (Mtb) strains has put on the spot the necessity of improved TB regimens. In this framework, this review article presents the main relevant research outcomes of nanotechnology in …
Michele L Pearson, MD, Sara J Whitehead, MD
…lthcare facilities has been intensified by the emergence of drug-resistant TB strains, including extensively resistant TB strains, and the high mortality of these strains in people living with human immunodeficiency virus (HIV). Healthcare workers are at higher risk of both TB i…
A Umo, Olajide Joseph Akinjogunla, Nse O. Umoh, Geoffrey Ekonugwem Uzono
…ce TST is non-specific. This may have grave implications of drug toxicity and development of resistance to anti-TB drug among individuals harbouring NTM, but receiving anti-TB medication. The 76.7% agreement between the two tests is an indication that the 10 mm cut-off induration…
Siddig Ibrahim Abdelwahab, Manal Mohamed Elhassan Taha, Hazem Mathkour, Edrous Alamer, Saleh Mohammad Abdullah, et al.
…driving the need for innovative approaches in diagnosis and drug development. The integration of artificial intelligence (AI), particularly machine learning (ML), has enabled significant advancements in areas such as drug resistance prediction, radiomics, prognostic modeling, and…
Rattanak Visal Hean, David A. Sheffield, Kirsten Herbert, David Brewster
…ion; PCR) in bone marrow and lymph node samples. Rifampicin resistance was not detected by PCR. Central nervous system (CNS) involvement was excluded with lumbar puncture and magnetic resonance imaging (MRI) scan of the brain and spine. Antituberculous therapy was commenced on da…
Yi Chu Liang
…pidly losing efficacy due to the acceleration in antibiotic resistance emergence. It is therefore imperative to not only develop novel antibiotics, but to also look beyond antibiotic therapy and develop alternative treatment strategies. One such alternative strategy is host-direc…
Sethuraman N, Thirunarayan M, Subbulakshmi R, Lakshmisree V, Balasubramanian U
… automated culture systems (BacTALERT and MGIT). First-line drug susceptibility (INH, Rifampicin, Pyrazinamide, Ethambutol, Streptomycin) testing data were retrieved wherever available. Data were obtained for a period of 7 years from August 2010 to July 2017. Results A total of 1…
Karishma Saran, Tiziana Masini, Isaac Chikwanha, Gregory Paton, Rosalind Scourse, et al.
…es in diagnosis, models of care, treatment, prevention, and drug regulation to provide a snapshot of national TB policy adoption and implementation. We examine progress since an analogous 2015 survey of 23 of the same countries. Results At the time of the survey, many countries h…
Yogendra Shah
…h topics as mechanisms associated with increasing trends of drug-resistant TB, the development of anti-mycobacterial drugs, genotyping tools, diagnosis and treatment of latent tuberculosis infection, and more.
Sharma N, Basu S, Chopra KK, Sharma P
…on attributed to the treatment hesitancy were concerns over drug side effects 19 (31.7%), emergence of drug resistance 11 (18.3%) and the likelihood of reinfection 4 (6.7%). Support for expansion of preventive therapy among household TB contacts was varied, with maximum (41.2%) p…
Flores-Gonzalez J, Urbán-Solano A, Ramón-Luing LA, Cancino-Diaz JC, Contreras-Rodriguez A, et al.
…ients show an immune fingerprinting. However, patients with drug-sensitive- (DS-TB) or drug-resistant- (DR-TB) TB have altered frequencies of circulating B cells. DS-TB and DR-TB display a unique profile characterized by high systemic levels of IFN-γ, IL-10, IgG, IgG/IgM ratio, a…
Sara H Bares, Susan Swindells
…mitant TB-preventive therapy and ART are complex because of drug–drug interactions, but these can be managed. Recent clinical trials of shorter preventive regimens have demonstrated safety and efficacy in PWH with higher completion rates. More research is needed to guide TB-preve…
Jyoti S. Mathad, MD, MSc
The purpose of this study was to evaluate the pharmacokinetics (PK), tolerability, and safety of once-weekly doses of rifapentine (RPT) and isoniazid (INH) in HIV-1-infected and HIV-1-uninfected pregnant and postpartum women with latent tuberculosis (TB). TB is a major cause of …
Sundararajan S, Muniyan R
…ycobacterium tuberculosis (Mtb). Alongside the emergence of drug-resistant TB, latent TB has worsened the condition. The tubercle bacilli are unusually behaved and successful with its strategies to modulate genes to evade host immune system and persist within macrophages. Under l…
Habibi P, Daniell H, Soccol CR, Grossi-de-Sa MF
…HIV and TB in a resource-limited setting because plant-made drugs can be produced efficiently and inexpensively in developing countries and could be shared by the available agricultural infrastructure without the expensive requirement needed for cold chain storage and transportat…
Sérvio R, Silva AR, Fernandes S, Tavares R, Rodrigues P
…llenges associated with TB treatment, including the risk of drug toxicity, medication adherence, and the potential for drug resistance. Treatment duration for miliary TB is extended, typically lasting nine months to a year, and may require adaptation based on the patient's clinic…
Indah Aprilia
…he first line is the SSRI group. Furthermore, patients with drug withdrawal or treatment failure, high risk of drug resistance, bad stigma about their disease will increase the risk of depression.
Furin J, Cox H, Pai M
… situation. Although little has changed in the treatment of drug-susceptible tuberculosis, data on increased efficacy with new and repurposed drugs have led WHO to recommend all-oral therapy for drug-resistant tuberculosis for the first time ever in 2018. Studies have shown that …