Showing 76–100 of 200 documents
Sorted by hybrid relevance (keyword + semantic via RRF)
Andrew D. Kerkhoff, Adithya Cattamanchi, Monde Muyoyeta, Claudia M. Denkinger, David W. Dowdy
Simon Mendelsohn and colleagues (June, 2021)1Mendelsohn SC Fiore-Gartland A Penn-Nicholson A et al.Validation of a host blood transcriptomic biomarker for pulmonary tuberculosis in people living with HIV: a prospective diagnostic and prognostic accuracy study.Lancet Glob Health. …
Elin Folkesson
…nd post-treatment cure. These approaches could transform TB diagnostics, reduce diagnostic delays, and support global TB elimination efforts.</p><h3>List of scientific papers</h3><p dir="ltr">I. A protein signature associated with active tuberculosis ident…
Elin Folkesson
…nd post-treatment cure. These approaches could transform TB diagnostics, reduce diagnostic delays, and support global TB elimination efforts.</p><h3>List of scientific papers</h3><p dir="ltr">I. A protein signature associated with active tuberculosis ident…
Umubyeyi Nyaruhirira A, Scholten JN, Gidado M, Suarez PG
…(COVID-19) undermines control of other infectious diseases. Diagnostics are critical in health care. This opinion paper explores approaches for leveraging diagnostics for COVID-19 while retaining diagnostics for other infectious diseases, including tuberculosis (TB) and HIV. The …
Caitlin A. Moe, Rita Kabuleta Luswata, Jheannie Barrameda, Hien Le, Seke Muzazu, et al.
ABSTRACT Background Tongue swabs are a promising alternative specimen for tuberculosis (TB) diagnosis, with high specificity (>98%) but lower sensitivity than sputum-based molecular tests. We investigated whether increased sample availability could offset lower sensitivity, re…
Johsuke Hara, Masaki Fujimura, Masahide Yasui, Reiko Takeda, Noriyuki Ohkura
Abstract Background We previously elucidated the fundamental pathophysiological features of various aetiologies of chronic cough, such as cough variant asthma, atopic cough, and sinobronchial syndrome. We also established a pathophysiological diagnostic procedure for aetiology id…
Yue Gao, Ling Hai, Yan Niu, Hong-Zhe Zhu, Rui Niu, et al.
**BACKGROUND:** Interleukin-27 (IL-27) in the pleural fluid has gained significant attention as a diagnostic biomarker for tuberculous pleural effusion (TPE); however, considerable variability exists across available studies. This systematic review and meta-analysis aimed to dete…
Miller AC, Cavanaugh JE, Arakkal AT, Koeneman SH, Polgreen PM
Background The incidence of diagnostic delays is unknown for many diseases and specific healthcare settings. Many existing methods to identify diagnostic delays are resource intensive or difficult to apply to different diseases or settings. Administrative and other real-world dat…
Hongling Wang, Liyan Jiang, Yang Xiao, Linlin Xu, Ning Zhang, et al.
**OBJECTIVES:** Systemic lupus erythematosus (SLE) is a life-threatening autoimmune disorder causing multi-organ damage. Current diagnostic methods are hindered by inadequate sensitivity and specificity of conventional biomarkers, which frequently delay diagnosis. Therefore, iden…
Muhammad Kashif Munir
…attle against Koch’s disease is still being fought and that diagnostics remain the frontline weapon.1 The history of tuberculosis (TB) diagnostics is, in many ways, the history of microbiology itself. From microscopy and culture to molecular assays capable of detecting resistance…
Tulane University
Pediatric tuberculosis (TB) continues to pose diagnostic challenges in low- and middle-income countries with high rates of TB disease, due to the well-described impact of paucibacillary disease in children, and current TB culture and polymerase-chain reaction tests are of limited…
Barkha Vimal, Saurabh Purohit, Albail Singh Yadav
Background: Abdominal tuberculosis (TB) remains a significant diagnostic challenge due to its nonspecific presentation and the limited sensitivity and specificity of conventional diagnostic modalities such as ultrasonography (USG) and contrast-enhanced computed tomography (CECT).…
Fahad Nazir, Qiam Ud Din, Zubariah, Saba Afzal Shaikh, Ibrahim, et al.
Objective: To determine the diagnostic accuracy of Mantoux’s test and diagnostic BCG test in the diagnosis of tuberculosis in children by taking AFB (acid fast bacilli) sputum test as gold standard. Study Design: Cross Sectional study. Setting: Imran Idrees Teaching Hospital Sial…
Bachti Alisjahbana, Professor, MD, PhD
…ive TB cannot produce adequate sputum specimens, current TB diagnostics rely on sputum-based tests. Therefore, the use of near point-of-care (nPOC) or point-of-care (POC) non-sputum-based tests can potentially provide more accessible TB diagnosis and reduce delays. This CRCT is …
Broger T, Marx FM, Theron G, Marais BJ, Nicol MP, et al.
…le. Despite the roll-out of molecular WHO-recommended rapid diagnostics to replace sputum smear microscopy over the past decade, a large diagnostic gap remains. Of the estimated 10·6 million people who developed tuberculosis globally in 2022, more than 3·1 million were not diagno…
Anvita Gupta Malhotra, Leena Lokhande, Abhijit Pakhare, Payal Soni, Satya Prakash Vishwakarma, et al.
… These findings advocate for integrating advanced molecular diagnostics into routine tuberculosis workflows to reduce diagnostic delays and improve patient outcomes. **CLINICAL TRAIL NUMBER:** Not applicable.
Wen Rao, Dafu Wang, Xiaoxue Ma, Jian Zhou, Tingting Gong, et al.
**BACKGROUND:** Rifampicin-resistant tuberculosis (RR-TB) constitutes a persistent and formidable challenge for global TB control programs, as delayed diagnosis and treatment initiation contribute to transmission and poor outcomes. Molecular drug susceptibility testing (mDST) ena…
Raizada N, Khaparde SD, Swaminathan S, Sarin S, Salhotra VS, et al.
…te of the increasing availability of rapid high-sensitivity diagnostics in public and private sectors, majority of paediatric TB cases are empirically diagnosed, without laboratory confirmation. To address these diagnostic challenges, World Health Organization (WHO) has recommend…
Huang JH, Chen H, Zhang ZC, Gu J, Yan L, et al.
Background and objective Cancer ratio (CR), which is defined as serum lactate dehydrogenase (LDH) to pleural fluid adenosine deaminase (ADA) ratio, has been reported to be a useful diagnostic marker for malignant pleural effusion (MPE). Whether its diagnostic accuracy is affected…
Weijia Lin, Zhi Liu, Yaping Zhang, Yanan Yu, Yang Liu, et al.
Objective: To investigate the clinical diagnostic value of TB-IGRA (Tuberculosis-Interferon Gamma Release Assay), PPD (Intradermal Tuberculin Test), TB-DNA-PCR (Tuberculosis-Deoxyribonucleic-Polymerase Chain Reaction) and ADA(Adenosine Aeaminase) in tuberculous pleural effusion. …
Adithya Cattamanchi, MD
…people with TB remain undiagnosed and 1 million die. Better diagnostics are essential to reducing the enormous burden of TB worldwide. The Rapid Research in Diagnostics Development for TB Network (R2D2 TB Network) brings together experts in TB care, technology assessment, diagnos…
Adithya Cattamanchi
…people with TB remain undiagnosed and 1 million die. Better diagnostics are essential to reducing the enormous burden of TB worldwide. The Assessing Diagnostics At Point-of-care for Tuberculosis (ADAPT) study seeks to reduce the burden of TB worldwide by evaluating faster, simple…
Zou X, Zhu Y, Hu Q, Qi Q, Hua H, et al.
Background To investigate the diagnostic value of bronchial ultrasound-guided transbronchial lung biopsy (EBUS-TBLB) in tuberculous peripheral pulmonary lesions. Methods A total of 770 patients who completed CT imaging and ultrasound bronchoscopy were retrospectively analyzed. Al…
Ibrahim Adamu, Nura Umaru, Adamu Mohammed Sani, Ali Adamu Abdullahi, Jabir Hamza Adamu, et al.
**PURPOSE:** Pulmonary tuberculosis (PTB) continues to be a major public health burden, a situation exacerbated by significant diagnostic gaps. Conventional testing relies heavily on sputum samples, but many patients are unable to produce adequate and qualitative sputum. This lim…
Ismail IM, Kibballi Madhukeshwar A, Naik PR, Nayarmoole BM, Satyanarayana S
Background In India, ensuring all Persons with Presumptive TB (PPTB) undergo TB diagnostic tests and initiating all diagnosed TB patients on treatment are two major implementation challenges. Objectives In a coastal district of Karnataka state, South India, to (1) determine the n…