Showing 76–100 of 200 documents
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Анна Старшинова, Yulia Zinchenko, E. V. Istomina, Natalia Basantsova, M. V. Filatov, et al.
Early diagnosis of tuberculosis remains essential for the prevention of the disease and control of its incidence. The diagnosis of latent tuberculosis infection (LTBI) has significantly improved over the last years due to the use of new immunological tests, including the Diaskint…
Н. А. Стогова, Olga A. Panina
Aim: to study the prevalence of latent tuberculosis infection (LTI) among individuals with residual post-tuberculosis changes in the lungs and assess the effectiveness of the Diaskintest® for LTI detection. Materials and methods. We carried out a retrospective analysis of results…
Tao Ding, Y. Mei
…nts with rheumatoid arthritis (RA) are at increased risk of tuberculosis infection, including active tuberculosis (ATB) and latent tuberculosis infection (LTBI). Treatment with immunosuppressive agents in patients with RA also increases the risk of ATB, the main reason for which …
Rukhshan Khurshid, Farwa Sijjeel, Samar Asim, Maira Mahmood, Huma Ashraf, et al.
Tuberculosis (TB) is endemic in many developing countries including Pakistan. It is a leading cause of death from a single infectious agent worldwide. Identification and early treatment of latent conditions help reduce the complications associated with TB. However, the identifica…
Makatsa MS, Omondi FMA, Bunjun R, Wilkinson RJ, Riou C, et al.
The development of a highly effective tuberculosis (TB) vaccine is likely dependent on our understanding of what constitutes a protective immune response to TB. Accumulating evidence suggests that CD4 + T cells producing IL-22, a distinct subset termed "Th22" cells, may contribut…
Yu. V. Myronchuk, O. O. Pushnova, L. I. Chernyshоva, O. V. Dvizov
…monstrate the features of detection and diagnosis of latent tuberculosis infection and pulmonary tuberculosis in children from household contacts based on own clinical observation.
 Materials and methods. A clinical case of own observation of pulmonary tuberculosis and laten…
Mikhail V. Fursov, I. A. Dyatlov, В. Д. Потапов
Modeling of tuberculosis infection is carried out in order to clarify various aspects of the tuberculosis pathogenesis, as well as the testing of new anti-tuberculosis drugs. The characteristic of in vitro models (n = 16) for Mycobacterium tuberculosis dormant state and in vivo m…
Jarvela J, Moyer M, Leahy P, Bonfield T, Fletcher D, et al.
Tuberculosis (TB) remains a worldwide public health threat. Development of a more effective vaccination strategy to prevent pulmonary TB, the most common and contagious form of the disease, is a research priority for international TB control. A key to reaching this goal is improv…
Meier NR, Jacobsen M, Ottenhoff THM, Ritz N
Background: Current immunodiagnostic tests for tuberculosis (TB) are based on the detection of an immune response toward mycobacterial antigens injected into the skin or following an in-vitro simulation in interferon gamma-release assays. Both tests have limited sensitivity and a…
Essone PN, Leboueny M, Maloupazoa Siawaya AC, Alame-Emane AK, Aboumegone Biyogo OC, et al.
Tuberculosis (TB) is the leading cause of death due to an infectious agent, but only a small fraction of those infected develop the disease. Cytokines are involved in the mediation and regulation of immunity, and their secretion patterns may reflect the infection status. To incre…
Kang J, Jeong DH, Han M, Yang SK, Byeon JS, et al.
Background We investigated the incidence of active tuberculosis among patients with inflammatory bowel disease (IBD) treated with tumor necrosis factor (TNF) inhibitors, with or without latent tuberculosis infection (LTBI). Methods The study was performed at a Korean tertiary ref…
Graves SK, Augusto O, Viegas SO, Lederer P, David C, et al.
…can healthcare workers have high rates of latent and active tuberculosis, but occupational screening for tuberculosis is not routine in this setting. Furthermore, the specificity of tuberculin skin testing in this population compared with interferon gamma release assay testing ha…
Qiu X, Tang Y, Zou R, Zeng Y, Yue Y, et al.
…-gamma release assay are not good at differentiating active tuberculosis from latent tuberculosis. Interferon-gamma-induced protein 10 (IP-10) has been widely used to detect tuberculosis infection. However, its values of discriminating active and latent tuberculosis is unknown. T…
Hirai N, Kasahara K, Yoshihara S, Nishimura T, Omori K, et al.
…d man with primary myelofibrosis who developed disseminated tuberculosis during treatment with ruxolitinib at 15 mg twice daily and prednisone at 5 mg. We also reviewed the literature on patients who developed tuberculosis during treatment with ruxolitinib. There are 13 case repo…
L. V. Slogotskaya, М. В. Синицын, D.А. Kudlаy
…ticle assesses existing immunological tests aimed to detect tuberculosis infection (tuberculin skin test, IGRA, skin test with a recombinant tuberculosis allergen). The latest inventions in the development of immunological tests that can differentiate latent tuberculosis infectio…
Ralph A Stidham, Rachel G Tyler
Tuberculosis (TB) remains a force health protection threat to the U.S. military, particularly in crucial populations at increased risk of exposure or re-activation. This analysis examined TB testing trends and the prevalence of latent tuberculosis infection (LTBI) among U.S. Army…
Rabe H, Lönnermark E, Johansson E, Gilljam M, Jönsson B
Mycobacterium tuberculosis and opportunistic environmental non-tuberculous mycobacteria (NTM) can cause severe infection. Why latent tuberculosis infection advances to active disease, and why some individuals with cystic fibrosis (CF) develop pulmonary infections with NTM is stil…
Olga Bilogortseva, Ya. I. Dotsenko, Oksana Sivachenko, L. V. Arefyeva, V. V. Gorbenko, et al.
…h LTBI represent a large risk group for reactivation of the tuberculosis process at any time. The available diagnostic methods do not answer the question regarding the risk of local TB formation in them. Aim: to present a model for predicting the risk of developing localized tube…
Fang Y, Wang N, Tang L, Yang XJ, Tang Y, et al.
Background Active tuberculosis (ATB) originates from primary Mycobacterium tuberculosis (MTB) infection or reactivation of latent tuberculosis. Besides bacteriological examination, MTB-reactive immunocytes detection can be an alternative testing for discrimination of active tuber…
Ikuta K, Ota Y, Kuroki S, Matsumoto Y, Senda E, et al.
Treatment of latent tuberculosis infection (LTBI) reduces the probability of reactivation of tuberculosis associated with anti-tumor necrosis factor (TNF) α inhibitors, but no chemoprophylaxis is completely protective. We herein report a woman with rheumatoid arthritis who develo…
Davoud Sadeghi Gariz, Nader Mosavari
Background and Objectives: Tuberculosis (TB) is an infectious disease and about one-third of the world population are infected with latent TB infection. Active TB infection may develop in 5 to10 percent of individuals with latent infection; therefore, detection of latent infectio…
Mohamed E. El Zowalaty, Hossam M. Ashour
Tuberculosis (TB) remains a challenge and threat to public health despite being a curable and preventable infectious disease. TB is caused by a potentially serious respiratory acid-fast bacillus Mycobacterium tuberculosis (Mtb). As one of the top ten causes of death globally, the…
H-C Lai, K-S Cheng, Chia‐Hsuin Chang, C-L Feng, T-W Chen, et al.
…ern countries, low prevalence of IBD and high prevalence of tuberculosis infection were reported in Taiwan. Biological agents are a great advance in treating patients with IBD, but they can increase the risk of tuberculosis (TB) infection. This study was to investigate the incide…
Jingyan Zhang, Qiangsen Zhong, Xiaochun Wang
…imely diagnosis is crucial for reducing the transmission of tuberculosis.In this study, we constructed and expressed PhoY2, a persistent infection related antigen of Mycobacterium tuberculosis and evaluated its potential as a diagnostic target through population experiments.The i…
Bielecka T, Augustynowicz-Kopeć E, Gonerko P, Gruszczyński P, Korzeniewska-Koseła M, et al.
Since the second half of the 20th century the incidence of tuberculosis has been declining in Poland. Despite this, current epidemiological data still support the need for the continued mass BCG vaccination in Poland in the near future. Apart from the protection against severe he…