Showing 51–75 of 103 documents
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Vyazovaya A, Levina K, Zhuravlev V, Viiklepp P, Kütt M, et al.
…ives We assessed the genetic structure of the Mycobacterium tuberculosis population in Estonia with a special focus on major epidemic/endemic clones and drug resistance determinants. We investigated the hypothesis of the decisive impact of massive human influx on the locally circ…
E. S. Ovsyankinа, Л. В. Панова, E. A. Krushinskaya, М. А. Багиров
…rt-curse chemotherapy regimens for treatment of MDR/pre-XDR tuberculosis in combination with surgery in older children and adolescents. Subjects and Methods. 51 patients with MDR/pre-XDR respiratory tuberculosis aged 13-17 years were enrolled in a prospective open study (2017-202…
Rizvan Abdullaev, A. M. Tikhonov, V. A. Shorokhova, О. Г. Комиссарова
…stry during chemotherapy of patients with MDR/XDR pulmonary tuberculosis receiving the short-course regimen containing bedaquiline, pretomanid, and linezolid (B-Pa-L). Subjects and Methods . 18 patients with MDR/pre-XDR/XDR pulmonary tuberculosis were enrolled into the study. The…
А. I. Gayda, A. V. Abramchenko, M. I. Romanova, T. V. Toichkina, V. S. Burykhin, et al.
…nts with multiple/pre-extensive drug resistant (MDR/preXDR) tuberculosis who interrupted treatment at different time points. Subjects and Methods. 800 patients with MDR/preXDR tuberculosis were enrolled in the study, they were from all regions of the Russian Federation and they s…
Soumya Renji, Rekha Solomon, Deepali Wankhade, Soonu Udani, Vrajesh Udani
…children admitted in our PICU with bacteriologically proven tuberculosis (smear, culture, poly-merase chain reaction, genotypic testing or Pyrosequencing) between January, 2007 and December, 2019 were retrieved. Drug resistance was classified as per World Health Organization defi…
М.В. Ураксина, E. P. Еremenko, Е. А. Бородулина, B. Borodulin
The main problem in the treatment of tuberculosis (TB) patients is the increase in drug resistance of M.tuberculosis, which is not always detected at the start of chemotherapy, which leads to inadequate and lengthy treatment. Research objective . Analysis of the treatment of newl…
ntroduction. Culture research and testing of Mycobacterium tuberculosis (MBT) for drug susceptibility in the Russian Federation is carried out with uneven qual-ity, which distorts the idea of primary drug resistance (DR). Aim. To study the primary DR of MBT to the main combinatio…
Liang Z, Liao W, Chen Q, Li H, Ye M, et al.
…is the most devastating and critical form of extrapulmonary tuberculosis. Here, we present a case of a 45-year-old male with pre-extensive drug-resistant tuberculosis meningitis (pre-XDR-TBM). He underwent emergency surgery for the long-tunneled external ventricular drainage (LTE…
Ushtanit A, Kulagina E, Mikhailova Y, Makarova M, Safonova S, et al.
…n group C of the WHO recommended drugs for the treatment of tuberculosis resistant to rifampicin and multidrug-resistant tuberculosis. The clinical relevance of ethionamide and prothionamide has increased with the wide spread of resistant tuberculosis. Methods We retrospectively …
Igor Mokrousov, V. V. Sinkov, П. А. Хромова, Alena Gerasimova, Ekaterina Chernyaeva, et al.
The <i>Mycobacterium tuberculosis</i> Mlva cluster 1071-32 belongs to the early ancient sublineage of the Beijing genotype. We have recently demonstrated its association with pre-XDR/XDR, increase in prevalence in parts of Russia (Northwest, Center, Siberia) and sporadic isolatio…
Y. I. Feshchenko, М. С. Опанасенко, О. V. Теreshkovych, S. М. Shalahai, О.И. Белогорцева, et al.
Tuberculosis (TB) in children is a complex of medical, biological and social problem of both international and national importance for many countries of the world and remains one of the main causes of death in the world. Surgical treatment can improve the results of treatment of …
Tatiana Umpeleva, Kseniya Belousova, Ludmila Golubeva, Nataliya I. Eremeeva, Diana Vakhrusheva
…ackground:</b> The Beijing B0/W148 is a clone variant of M. tuberculosis (MTB) that is often detected in tuberculosis patients in Russia. It has stronger association with multidrug resistance and possesses unique pathogenic properties. <b>Objectives:</b> To identify the spectrum …
San LL, Aye KS, Oo NAT, Shwe MM, Fukushima Y, et al.
Objectives Myanmar is a World Health Organization high tuberculosis (TB) burden country with a high multidrug-resistant (MDR)-TB burden. Of significance, a high prevalence of the Beijing genotype of Mycobacterium tuberculosis (MTB) among MDR-MTB has been reported previously. A de…
João Paulo de Lucena Laet, Lílian Maria Lapa Montenegro, Ana Lúcia Figueiredo Porto, Fábio Rocha Formiga, Ronaldo Nascimento de Oliveira, et al.
Tuberculosis (TB) is a chronic infectious disease that represents one of the greatest global public health challenges, especially in light of the increasing prevalence of resistant strains. Triazole-class molecules have been widely studied as promising candidates for new therapeu…
Fábio Rocha Formiga, Giovanna Gabriela Pedroza Rodrigues, Luanna de Ângelis Correia de Sousa, Douglas Dourado Oliveira, Ronaldo Nascimento de Oliveira, et al.
… of new bioactive compounds is a promising strategy against tuberculosis (TB), a disease caused mainly by Mycobacterium tuberculosis (Mtb). This approach becomes even more relevant given the increase in resistance to traditional drugs. Triazole derivatives emerge as relevant cand…
Che Y, Bo D, Lin X, Chen T, He T, et al.
…Detection of pyrazinamide (PZA) resistance in Mycobacterium tuberculosis (TB) patients is critical, especially in dealing with multidrug-resistant Mycobacterium tuberculosis (MDR-TB) case. Up to date, PZA drug susceptibility testing (DST) has not been regularly performed in China…
Kardan-Yamchi J, Amini S, Hamzelou G, Rahimi Foroushani A, Ghodousi A, et al.
…l VER 2.0 was used to detect resistance to second-line anti-tuberculosis drugs on 35 rifampicin-resistant M. tuberculosis (RR-MTB) isolates compared to the minimum inhibitory concentrations (MICs) and whole genome sequencing (WGS). The MTBDRsl VER 2.0 (Hain Life Science, Nehren, …
Schami A, Islam MN, Wall M, Hicks A, Meredith R, et al.
…ecent decades, drug resistant (DR) strains of Mycobacterium tuberculosis (M.tb), the cause of tuberculosis (TB), have emerged that threaten public health. Although M.tb's complex and protective cell envelope has been widely studied, little is known about how levels of peripheral …
Yogesh Yadav, JYOTI CHOUDHARY, MOHAMMED NASIR KHAN
Objective: This study aimed to identify drug-resistant tuberculosis cases and treatment results. Because it is one of the few studies that have looked at the results of TB treatment among children in the nation, this one was noteworthy. Methods: Drug-resistant cases of paediatric…
Greif G, Coithino C, Bentancor MN, Robello C
…nome sequencing (WGS) is sensitive tool for the analysis of tuberculosis transmission and drug-resistance. We used WGS to analyze the Mycobacterium tuberculosis evolution from isoniazid monoresistance to MDR/preXDR during a prolonged household outbreak. The outbreak started with …
Hameed HMA, Tan Y, Islam MM, Guo L, Chhotaray C, et al.
…) are the cornerstones for treatment of multidrug-resistant tuberculosis (MDR-TB). China is one of the highest MDR- and fluoroquinolones (FQ)-resistant TB burdens countries. DNA gyrase encoded by gyr genes is the main target of FQ in Mycobacterium tuberculosis (MTB). The prevalen…
Jantarabenjakul W, Supradish Na Ayudhya P, Suntarattiwong P, Thepnarong N, Rotcheewaphan S, et al.
Background The prevalence of drug-resistant tuberculosis (DR-TB) in adults has stabilized in the past decade. Our study aimed to describe the prevalence of DR-TB in Thai children between 2006 and 2021. Materials and methods Children younger than 15 years old who had culture-confi…
Mogashoa T, Loubser J, Choga OT, Ngom JT, Choga WT, et al.
Background The emergence of drug-resistant Mycobacterium tuberculosis ( M. tb ) strains remains a threat to tuberculosis (TB) prevention and care. Understanding the drug resistance profiles of circulating strains is crucial for effective TB control. This study aimed to describe t…
Naima Nur, Azaz Bin Sharif, Anish Khan, Md Rashedul Islam, Hafid Soualhine, et al.
To effectively manage tuberculosis (TB), it is essential to address the high incidence of the disease, as multidrug-resistant pulmonary TB (MDR-PTB) remains a significant concern to halt pre-extensive drug-resistant (pre-XDR) recrudescence. The objective of the current study was …
R. V. Tarasov, E. V. Krаsnikovа, Л. Н. Лепеха, S. S. Sаdovnikovа, М. А. Багиров
…ment of the patient with disseminated destructive pulmonary tuberculosis with preXDR. The treatment included staged surgery using the original method of anterior mediastinum plasty with a mesh implant. The treatment resulted in the following outcomes: stabilization of the tubercu…