Showing 51–75 of 200 documents
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Burusie A, Enquesilassie F, Salazar-Austin N, Addissie A
…g the implementation of the World Health Organization's End Tuberculosis (TB) Strategy is the treatment outcome rate. Objective This study aims to assess the magnitude of unfavorable treatment outcomes and estimate their relationship with baseline undernutrition and sustained und…
de Groot LM, Straetemans M, Maraba N, Jennings L, Gler MT, et al.
Worldwide, non-adherence to tuberculosis (TB) treatment is problematic. Digital adherence technologies (DATs) offer a person-centered approach to support and monitor treatment. We explored adherence over time while using DATs. We conducted a meta-analysis on anonymized longitudin…
Ahmad Fuady
Estimating tuberculosis incidence, prevalence, and deaths are crucial to capture the tuberculosis burden and to assess the progress towards tuberculosis elimination in 2035. WHO publishes a report of estimated tuberculosis burden each year, showing that tuberculosis remains among…
Helena Rabie, Marieke M. van der Zalm
Rapid microbiological confirmation of Mycobacterium tuberculosis (M tuberculosis) in sputum with nucleic acid amplification tests (TB-NAAT) is an important step to diagnose tuberculosis and to identify possible drug resistance. These tests significantly increase the diagnostic yi…
Lindsay McKenna, Jennifer Furin
Around 10 million people become sick with tuberculosis, and more than 1·2 million people die from the disease each year.1WHOGlobal Tuberculosis Report.https://www.who.int/tb/publications/global_report/en/Date: 2019Date accessed: October 31, 2019Google Scholar WHO has proposed som…
Merza MA
…and clinical profile and treatment outcomes in the National Tuberculosis Program Center of Duhok governorate. Methods This was a descriptive retrospective study of all forms of drug-susceptible tuberculosis cases in the National Tuberculosis Program Center of Duhok. The Electroni…
Said B, Charlie L, Getachew E, Wanjiru CL, Abebe M, et al.
The lack of rapid, sensitive, and deployable tuberculosis diagnostic tools is hampering the early diagnosis of tuberculosis and early detection of treatment failures. The conventional sputum smear microscopy or Xpert MTB/RIF assay cannot distinguish between alive and dead bacilli…
Robyn S. Lee, Jean‐François Proulx, Fiona McIntosh, Marcel A. Behr, William P. Hanage
…or response Article and author information Metrics Abstract Tuberculosis disproportionately affects the Canadian Inuit. To address this, it is imperative we understand transmission dynamics in this population. We investigate whether ‘deep’ sequencing can provide additional resolu…
Annelies Van Rie, Conor J. Meehan
…ing (WGS) approach to explore the within-host Mycobacterium tuberculosis (Mtb) microevolution in response to antibiotic pressure, the impact of Mtb genetic diversity on treatment outcome, and the clinical implication of hetero-resistance in 331 patients with a single-strain Mtb i…
Conor J. Meehan
…or response Article and author information Metrics Abstract Tuberculosis disproportionately affects the Canadian Inuit. To address this, it is imperative we understand transmission dynamics in this population. We investigate whether ‘deep’ sequencing can provide additional resolu…
Digby F. Warner, Robin Wood
Tuberculosis (TB) remains an enigmatic disease. Consistently among the leading causes of annual global mortality, its impact is greatest in a limited number of high-burden countries, many of which are marked by poverty, stark internal inequalities, societal instability and, since…
Malik AA, Farooq S, Jaswal M, Khan H, Nasir K, et al.
Background Shorter regimens for tuberculosis prevention can improve completion rates and protection against developing active tuberculosis disease after tuberculosis exposure. We aimed to assess the safety and feasibility of 1 month of daily isoniazid and rifapentine (1HP) in chi…
Seid G, Alemu A, Diriba G, Zerihun B, Abebaw Y, et al.
Introduction There is a global gap between tuberculosis incident cases and the notified cases. Active household contact investigation is one of the strategies to narrow this gap. It has the advantage of giving early diagnosis and preventive treatment to vulnerable and eligible gr…
First Affiliated Hospital of Zhejiang University
…and moxifloxacin for ethambutol) for treatment of pulmonary tuberculosis. The standard six-month regimen is two months of isoniazid, rifampin, ethambutol, and pyrazinamide, followed by four months of isoniazid and rifampin. The four-month regimen consists of two months of isoniaz…
Dongxia Zhu, Martin R. Bryce
…oviding insights for solid-state luminescence applications. Tuberculosis (TB) infection, caused by Mycobacterium tuberculosis, reveals tens of millions of new cases and causes millions of deaths each year. The traditional clinical treatment for TB is long-term and combined usage …
Churako H, Tesema M, Tema L, Ababiya T, Wodajo D, et al.
…als worldwide are afflicted by the fatal infectious disease tuberculosis, which accounts for thousands of avoidable deaths. The literature has provided a good description of the clinical manifestation and radiologic features of pulmonary tuberculosis. However, the parenchymal com…
du Preez K, Osman M, Seddon JA, Naidoo P, Schaaf HS, et al.
Background Few studies have evaluated tuberculosis control in children and adolescents. We used routine tuberculosis surveillance data to quantify age- and human immunodeficiency virus (HIV)-stratified trends over time and investigate the relationship between tuberculosis, HIV, a…
Chanjuti Sriruan, Watchara Kasinrerk, Sorasak Intorasoot, Bordin Butr-Indr, Nathiprada Netirat, et al.
Background: Mycobacterium tuberculosis is the most common causative agent of tuberculosis. It releases secretory proteins, especially the Ag85 complex, from actively growing mycobacteria, which can be detected in mycobacterial liquid culture. Ag85B is the most abundant in the Ag8…
Nie L, Tong J, Wu G, Du J, Shang Y, et al.
…afloxacin has a potent killing effect against Mycobacterium tuberculosis , including drug-resistant strains, which is superior to that of other available quinolones. However, its efficacy in patients with primary-sensitive tuberculosis is unclear. This study aims to evaluate the …
Yiwang Chen, Howard Takiff, Qian Gao
…wn great potential in the rapid diagnosis of drug-resistant tuberculosis;1Finci I Albertini A Merker M et al.Investigating resistance in clinical Mycobacterium tuberculosis complex isolates with genomic and phenotypic antimicrobial susceptibility testing: a multicentre observatio…
Iskandar D, Suwantika AA, Pradipta IS, Postma MJ, van Boven JFM
Background The global incidence of tuberculosis is decreasing, yet it remains high in Indonesia. The Indonesian National Tuberculosis Program facilitates mandatory notification, which enables early detection and treatment, minimises complications, prevents transmission, and decre…
Susan Dorman, MD, Payam Nahid, MD, MPH, Susan Swindells, MBBS, Richard Chaisson, MD, Ekaterina V Kurbatova, MD, PhD, MPH
…y is to determine whether one or two four-month regimens of tuberculosis treatment are as effective as a standard six-month regimen for treatment of pulmonary tuberculosis (TB). All three regimens are administered daily, seven days each week, with direct observation of each dose …
B. P. Pirmakhmadzoda, Z. Kh. Tilloeva, Kh. S. Sharifzoda, Olim Kabirov, K. A. Imomnazarova, et al.
The objective of the study: to determine the burden of tuberculosis with concurrent HIV infection in Dushanbe and the prevalence of multiple drug resistant tuberculosis, to assess the treatment efficacy of drug susceptible and drug resistant tuberculosis depending on the HIV stat…
Cross GB, Sari IP, Kityo C, Lu Q, Pokharkar Y, et al.
…ckground Shorter treatments are needed for drug-susceptible tuberculosis. Adjunctive statins increase bactericidal activity in preclinical tuberculosis models. We investigated the safety and efficacy of adjunctive rosuvastatin in people with tuberculosis. We tested the hypothesis…
Liu Q, You N, Pan H, Shen Y, Lu P, et al.
Rationale: Patients with newly diagnosed tuberculosis often have inconsistent glycemic measurements during and after treatment. Distinct glycemic trajectories after the diagnosis of tuberculosis are not well characterized, and whether patients with stress hyperglycemia have poor …