Showing 51–75 of 200 documents
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Roxana Mansour Ghanaie, Abdollah Karimi, Leila Azimi, Seddon James, Mahshid Nasehi, et al.
… Although the World Health Organization has recommended the diagnosis and prophylactic treatment of latent tuberculous infection (LTBI) in child household contacts of tuberculosis (TB) cases, the national programs in high-burden TB regions rarely implement adequate screening of t…
Kissling M, Fritschi N, Baumann P, Buettcher M, Bonhoeffer J, et al.
…to-lymphocyte-ratio (MLR) may have diagnostic potential for tuberculosis (TB). Methods Data of two prospective multicenter studies in Switzerland were used, which included children Results Of the 389 children included 25 (6.4%) had TB disease, 12 (3.1%) TB infection, 28 (7.2%) we…
Shruti Kaushal, Sunil Kumar Dhatwalia, Rakesh Yadav, Sumedha Sharma, Pankaj C Vaidya, et al.
…ra), as first-line diagnostic tests for detecting pulmonary tuberculosis (PTB) and rifampicin resistance in children suspected of having the disease. Respiratory specimens (gastric lavage/bronchoalveolar lavage/sputum/endotracheal aspirate) obtained from 116 children with presump…
Ghanaie RM, Karimi A, Azimi L, James S, Nasehi M, et al.
… Although the World Health Organization has recommended the diagnosis and prophylactic treatment of latent tuberculous infection (LTBI) in child household contacts of tuberculosis (TB) cases, the national programs in high-burden TB regions rarely implement adequate screening of t…
Luo Y, Yang X, Zhou J, Pu S, Wang Y
The clinical symptoms of tuberculosis infection in children are not typical and need to be distinguished from many diseases, and the tumor is one of them. We present a case of cervical lymphadenopathy in a child with positive purified protein derivative (PPD) and Interferon-Gamma…
Amodini Lakshmeswar, Mamta N. Anand, M B Koujalgi
…ackground: In India, an estimated 220,000 children contract tuberculosis (TB) annually, yet the absence of a gold standard test hinders effective diagnosis and reporting of childhood TB. Objective: This study aimed to analyse the clinical profile of childhood tuberculosis, utiliz…
Torane VP, Nataraj G, Kanade S, Deshmukh CT
…objective Global TB report 2021 mentions 11 % prevalence of pediatric TB, whereas 5.65% of the cases were reported from India in 2020. India features in the list of TB high burden countries, HIV-TB high burden and MDR-TB high burden countries. The diagnosis of pulmonary tuberculo…
Ben J Marais, H Simon Schaaf
Tuberculosis (TB) is a major cause of disease and death in young children from TB-endemic countries, especially in areas affected by poverty, social disruption, and human immunodeficiency virus (HIV) infection. This article reviews the disease burden and the natural history of di…
Goussard P, Retief F, Burke J, Malherbe A, Janson J
… as a diagnostic and therapeutic procedure in children with Tuberculosis (TB) disease complicated by airway obstruction. It is needed in children when surgical intervention may be required for airway compression, when drug resistance is suspected, and to rule out an alternative d…
Jayagandan S, Singh J, Mudliar SR, Shankar P, Maurya AK, et al.
Objective Microbiological confirmation of tuberculosis (TB) in pediatric cases is challenging due to its paucibacillary nature and difficulty in specimen collection. This study aimed to validate stool as an alternative sample for the diagnosis of pediatric pulmonary TB via Xpert …
Ness TE, Meiwes L, Kay A, Mejia R, Lange C, et al.
The WHO has endorsed the use of stool samples for diagnosis of tuberculosis (TB) in children, and targeted next-generation sequencing (tNGS) of stool has been shown to support diagnosis and provide information about drug susceptibility (DS). Optimizing extraction of DNA from stoo…
Emel Aytaç Kaplan, Deniz Akan, Nazan Dalgıç, Emel Ekşi, Özge Yapıcı, et al.
Giri: Bu almann amac, ocukluk a akcier tberklozu tansnda spesifik bilgisayarl tomografi (BT) bulgularn tanmlamaktr
Ilaiwy G, Lukumay S, Augustino D, Mejan P, Bukhay R, et al.
At least a third of tuberculosis (TB) cases remain undiagnosed, disproportionately so in children and adolescents, which is hampering global elimination goals. Prolonged symptom duration presents a high-risk scenario for childhood TB in endemic areas, but the prolonged period of …
Tornheim JA, Madugundu AK, Paradkar M, Fukutani KF, Queiroz ATL, et al.
…kground Gene expression profiling is emerging as a tool for tuberculosis diagnosis and treatment response monitoring, but limited data specific to Indian children and incident tuberculosis infection (TBI) exist. Methods Sixteen pediatric Indian tuberculosis cases were age- and se…
Berlian Beatrix Rarome, Nurul Aisah, Retno Asih Setyoningrum, Ni Made Mertaniasih
The diagnosis of childhood tuberculosis remains a challenge worldwide. The GeneXpert MTB/RIF test, a rapid Mycobacteria tuberculosis diagnostic tool, was recommended for use in children. No pediatric studies of GeneXpert MTB/RIF assessing pulmonary tuberculosis within a hospital …
Rika Oktania Sari, Bayu Prabowo
Introduction: Pediatric tuberculosis can cause a variety of problems, including growth failure, disability, and death. In 2021, WHO recorded 10.6 million individuals had tuberculosis globally, with pediatric tuberculosis accounting for 11% of these cases. Indonesia is the second …
Nina T. Castillo-Carandang, Lauren M. Leining, Anna M. Mandalakas, Kristy O. Murray, Jinhua Liao, et al.
…r documents the experiences of rural physicians in managing pediatric tuberculosis (TB) cases before and after disasters in Bohol, Philippines. The participants are from the public and private healthcare systems in municipalities heavily affected and less affected by a 7.2-magnit…
E. S. Ovsyankinа, Л. В. Панова, И. Н. Захарова
Interdisciplinary interaction between phthisiatricians and pediatricians on the issues of detection and diagnosis of tuberculosis provides basis for the reduction of duration of the diagnostic process and the early identification of disease progression. The purpose of this review…
Sumona Datta, Carlton A. Evans
Tuberculosis is estimated to affect 10 million people each year, but this statistic is remarkably uncertain: 30% are countries' estimates of undiagnosed, untreated, or unreported cases. Furthermore, about half of tuberculosis diagnoses globally are uncertain because they rely ent…
Mete Yesil A, Yalcin E, Ademhan Turhal D, Emiralioglu N, Dogru D, et al.
…c profile, and treatment outcomes, and to draw attention to tuberculosis (TB) in Turkey. Methods . A retrospective, descriptive study was undertaken of 93 children aged 0 to 18 years who were admitted to Hacettepe University Pediatric Pulmonology Department for treatment from Jan…
Brendan Mullen, Joy Githua, Jaclyn N Escudero, Jerphason Mecha, Lucy Kijaro, et al.
Tuberculosis (TB) is a significant cause of morbidity and mortality in children and adolescents, causing 172,000 deaths in 2024 in children and adolescents worldwide. Diagnostic challenges are pronounced in pediatrics, in which collecting respiratory specimens is challenging and …
Laya BF, Concepcion NDP, Andronikou S, Abdul Manaf Z, Atienza MIM, et al.
Despite advances in diagnosis and treatment in recent years, tuberculosis (TB) remains a global health concern. Children are amongst the most vulnerable groups affected by this disease. Although TB primarily involves the lungs and mediastinal lymph nodes, it can affect virtually …
Marc d’Elbée, Nyashadzaishe Mafirakureva, Chishala Chabala, Minh Huyen Ton Nu Nguyet, Martin Harker, et al.
…ute malnutrition (SAM) are an important risk group for underdiagnosis and death from tuberculosis. In 2022, the World Health Organization (WHO) recommended use of treatment decision algorithms (TDAs) for tuberculosis diagnosis in children. There is currently no cost-effectiveness…
María I Urteneche, Norma E González, Eugenia Ginestet, Edith Macha Marín, Rosana Pereda, et al.
Introduction. Central nervous system tuberculosis (CNS TB) represents a severe form of Mycobacterium tuberculosis (Mtb) infection. Late diagnosis is associated with increased mortality and neurological sequelae. Objective. To characterize CNS TB diagnosed in a pediatric hospital …
Headriawan A, Pramono AA, Sukadi A, Chairulfatah A, Maskoen AM, et al.
Background As pediatric tuberculosis (TB) globally is still reported challenging in diagnosis, to date, a lot of efforts have been established to eliminate the disease including proper treatment regimen using anti-TB drugs. However, antituberculosis drug-induced hepatotoxicity (A…