Showing 51–75 of 200 documents
Sorted by hybrid relevance (keyword + semantic via RRF)
Adam Penn-Nicholson
Robust evidence on the clinical diagnostic accuracy and operational characteristics of the Bioneer Accupower Q-RFIA PCR kit on IRON qPCR is required to comprehensively evaluate validity of the Bioneer RFIA assay to support both global and national policy decision-making. The rap…
Ambuj Kumar Kushwaha, Abhisheka Bansal, Gunjan Arora, Divya Kushwaha
…egration of metabolomics with AI approaches could transform diagnostics for TB and other infectious diseases. Targeting Mycobacterium tuberculosis via vitamin C–primed Vγ9Vδ2 T-cells Although there are several vaccine candidates in clinical trials, the limitations of the current …
Xin Mao, Jingkai Wang, Junchi Xu, Ping Xu, Huijie Hu, et al.
…oscopy, culture-based methods, antigen detection, molecular diagnostics (including nucleic acid amplification tests and whole-genome sequencing), spectroscopic techniques (such as Raman spectroscopy), and mass spectrometry-based approaches. Notably, this review focuses on pathoge…
Akshay Minhas, Mitasha Singh, Shweta Goswami, Naresh Jeengar
…ck-level disparities. Strengthening decentralised molecular diagnostics, ensuring rapid treatment initiation, improving transport and social support, and targeting high-burden blocks are critical for aligning district performance with India’s End TB goal.
Pascal Lapierre, Joseph Shea, Shannon G. Murphy, Carol Smith, Donna Kohlerschmidt, et al.
…ational handbook on tuberculosis.Module 3: diagnosis -rapid diagnostics for tuberculosis detection, 2021). Consequently, validation studies may not include representative of the myriad of clinical samples and drug resistant profiles that a clinical laboratory may receive. Therefo…
Margherita Bracchi, Clare van Halsema, Frank A. Post, Funmi Awosusi, Alison Barbour, et al.
…formation – clinical, radiological, pathological, molecular diagnostics and results of treatment – can be critically reviewed. Because the presence of granulomas is regarded as typical of TB, differential diagnoses should be considered, especially if response to treatment is not …
Jingyi Dai, Qiujing Li, Juan Wan, Fengshuo Sun, Gang Zhou, et al.
…s. These findings underscore tNGS's potential to improve TB diagnostics and patient management through faster and more precise detection methods.IMPORTANCETuberculosis (TB) continues to be a leading cause of morbidity and mortality worldwide, particularly among marginalized popul…
Beijing Hospital
Background: Drug resistant tuberculosis is a serious public health problem that threatens the health of human life and the development of society and economy. At present, the diagnosis of drug-resistant tuberculosis mainly depends on traditional drug susceptibility test. But it …
Keertan Dheda, MD/PhD
Resistance to anti-tuberculosis drugs is a continually growing problem. Multidrug-resistant tuberculosis (MDRTB) is resistance to at least rifampicin and isoniazid, and extensively drug-resistant TB is additional resistance to a fluoroquinolone and a second injectable line drug. …
Sonia Islam Khan
…is review underscores the need for continuous innovation in diagnostics, treatment regimens, and patient-centered interventions to achieve global targets for TB elimination. Journal of National Institute of Neurosciences Bangladesh, July 2024;10(2):130-137
SushantSatish Mane
…as a silver lining, similarly, the new generation molecular diagnostics have revolutionized the microbiological diagnosis of TB in children. Cartridge-based nucleic acid amplification tests (Xpert-Rif™/Truenat™) and line probe assays (LPAs) have been approved and made available f…
Ekramy Elmorsy, Basil D. M. Alruwaili, Hatem R. H. Alrwaili, Anwar S. J. Alrawaili, Abdulelah Alanazi, et al.
…eatures and the limitations of conventional microbiological diagnostics. In ICU cohorts with tuberculosis, mortality rates range from 30% to 70%, with elevated rates observed in patients requiring mechanical ventilation or experiencing multi-organ failure. Delayed initiation of a…
Ruth Chipampe Kafwanka, Rogers Chilyabanyama, Richard Chirwa, Mubanga Lackson Chipimo
…efforts. While scientific advancements have led to improved diagnostics and treatment options, the continued spread of resistant TB strains threatens to undo decades of progress. This systematic review synthesizes evidence on the global patterns of antimicrobial resistance (AMR) …
Guiqing He, Chunxia Tu, Yelei Zhu, Qingyong Zheng, Qiulong Zhou, et al.
**UNLABELLED:** Resistance to pyrazinamide (PZA) poses significant challenges to tuberculosis (TB) management, and prediction of susceptibility to PZA has been challenging. This study examined PZA resistance-associated gene mutations in 125 multidrug-resistant clinical isolates o…
Tamara. Sneyd
…ime.The introduction of GeneXpert testing revolutionised TB diagnostics as it allowed for diagnosis of TB whilst also providing susceptibility results for rifampicin within a few hours.Direct 1 st and 2 nd line LPA testing was included in the DR-TB management algorithm to further…
Nadia A. Sam‐Agudu, Chandy C. John
…r Similarly, the availability and accessibility of COVID-19 diagnostics and treatments has greatly lagged for low- and middle-income countries compared with high-income countries.6Maluleke K. Musekiwa A. Kgarosi K. Gregor E.M. Dlangalala T. Nkambule S. Mashamba-Thompson T.A. A sc…
Salman Daneshi, Esmaeil Barkhori Mehni, Mohammad Kamali, Eshagh Barfar, Fatemeh Bagher Barahouei, et al.
**INTRODUCTION:** Drug-resistant tuberculosis (DR-TB) is an increasing public health concern in Iran, with multidrug-resistant tuberculosis (MDR-TB) posing significant challenges to disease control efforts. This study examines the prevalence of DR-TB in Iran from January 2000 to …
Keertan Dheda, MD PhD
…lling the global burden of TB. A number of promising new TB diagnostics have shown initial promise but there remains an urgent need to assess their impact when used at the point-of-treatment in primary care level. In 2009, Cepheid released the Xpert® MTB/RIF Assay, which is the …
Emmama Jamil, Muhammad Majid Aziz, Afreenish Amir, Brian Godman, Stephen M Campbell, et al.
…lability; (3) stewardship intentions constrained by delayed diagnostics and limited infrastructure and (4) underutilisation of preventive strategies including adult vaccinations due to cost and policy gaps. Physicians were aware of Infectious Diseases Society of America/American …
Swinkels HM, Jilani TN, Tobin EH
…enome sequence was mapped. Today, continued advancements in diagnostics, treatment, implementation science, epidemiological techniques, global cooperation, and research, amongst others, offer optimism for the prevention, control, and elimination of TB. The causative agent of TB, …
Carpi, Giovanna, Seifert, Marva, De la Rossa, Andres, Uplekar, Swapna, Rodrigues, Camilla, et al.
Background Rapid and accurate detection of drug-resistant tuberculosis (DR-TB) is crucial for ensuring effective treatment, halting transmission and preventing the amplification of resistance. Comparative evaluations of molecular diagnostic assays in high-burden settings are esse…
Foundation for Innovative New Diagnostics, Switzerland
Tuberculosis (TB) remains a life-threatening disease partly due to increasing incidence of multidrug and extensively drug-resistant TB. Diagnostic based on culture and conventional drug susceptibility testing using media take several weeks leading to prolonged periods of ineffect…
Mi Zhou, Xuren Chen, Jie Huang, Runlin Su, Hongmei Lei, et al.
…erscore the need for routine DST, wider access to molecular diagnostics, and child-friendly second-line regimens. Policy changes focused on decentralizing diagnostic services and adopting WHO-endorsed pediatric regimens are urgently required.
Saderi L, Puci M, Di Lorenzo B, Centis R, D'Ambrosio L, et al.
…e aim of this systematic review is to assess existing rapid diagnostics for pre-XDR/XDR-TB from a point-of-care perspective and describe their technical characteristics (i.e., sensitivity, specificity, positive and negative predictive values). Methods Embase, PubMed, Scopus, and …
Kia P, Ruman U, Pratiwi AR, Hussein MZ
…ous nanotherapeutic agents that have been developed for MTB diagnostics, anti-TB drugs and vaccine. Undoubtedly, the concept of employing nanoparticles (NPs) has strong potential in this therapy and offers impressive outcomes to conquer the disease. Nanocarriers with different ty…