Showing 51–75 of 200 documents
Sorted by hybrid relevance (keyword + semantic via RRF)
Bianca Sossen, Graeme Meintjes
…OHigh-priority target product profiles for new tuberculosis diagnostics: report of a consensus meeting. World Health Organization, Geneva2014Google Scholar There is a clear need for tests that are non-sputum based (eg, urine or blood) in people with HIV, since risk of mortality i…
Nathavitharana RR, Lederer P, Chaplin M, Bjerrum S, Steingart KR, et al.
Background Tuberculosis is the primary cause of hospital admission in people living with HIV, and the likelihood of death in the hospital is unacceptably high. The Alere Determine TB LAM Ag test (AlereLAM) is a point-of-care test and the only lateral flow lipoarabinomannan assay …
Mbarara University of Science and Technology
… referred to Mbarara Regional Referral Hospital for further diagnostics and care. A one-page triplicate referral form will be used to track referrals and ensure successful referral completion. The study team will conduct zoom conferences every fortnight with each of the four HC3 …
Richu Bob Kurien, Priya Nadesan, Balamugesh Thangakunam, Barney Isaac, Thomas Alex Kodiatte, et al.
Abstract Background Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is the preferred diagnostic modality for evaluating mediastinal lymphadenopathy. However, its diagnostic yield is significantly reduced in conditions such as sarcoidosis, tuberculosis…
Keertan Dheda, MBChB, PhD
… are not able to readily access clinic services. A standard diagnostics package consisting of smear microscopy and culture (with smear result available the next day) will be compared with a novel diagnostics package involving point-of-care sputum GeneXpert MTB/RIF performed at a …
Deo S, Singh S, Jha N, Arinaminpathy N, Dewan P
Background Tuberculosis (TB) incidence in India continues to be high due, in large part, to long delays experienced by patients before successful diagnosis and treatment initiation, especially in the private sector. This diagnostic delay is driven by patients' inclination to swit…
Emmanuel Bottieau, MD, Marleen Boelaert, MD, PhD
The impact of neurological disorders is enormous worldwide, and it is increased in poor settings, due to lack of diagnosis and treatment facilities as well as delayed management. In sub-Saharan Africa, the few observational studies conducted for the past 20 years show that neurol…
Human Sciences Research Council
In application studies of latent class analysis (LCA) evaluating imperfect diagnostic tests, residual dependence among the diagnostic tests still remain even after conditioning on the true disease status due to measured variables known to affect prevalence and/or alter diagnostic…
Keter AK, Lynen L, Van Heerden A, Goetghebeur E, Jacobs BKM
Background In application studies of latent class analysis (LCA) evaluating imperfect diagnostic tests, residual dependence among the diagnostic tests still remain even after conditioning on the true disease status due to measured variables known to affect prevalence and/or alter…
Andrew D. Kerkhoff, Adithya Cattamanchi, Monde Muyoyeta, Claudia M. Denkinger, David W. Dowdy
Simon Mendelsohn and colleagues (June, 2021)1Mendelsohn SC Fiore-Gartland A Penn-Nicholson A et al.Validation of a host blood transcriptomic biomarker for pulmonary tuberculosis in people living with HIV: a prospective diagnostic and prognostic accuracy study.Lancet Glob Health. …
Umubyeyi Nyaruhirira A, Scholten JN, Gidado M, Suarez PG
…(COVID-19) undermines control of other infectious diseases. Diagnostics are critical in health care. This opinion paper explores approaches for leveraging diagnostics for COVID-19 while retaining diagnostics for other infectious diseases, including tuberculosis (TB) and HIV. The …
Caitlin A. Moe, Rita Kabuleta Luswata, Jheannie Barrameda, Hien Le, Seke Muzazu, et al.
ABSTRACT Background Tongue swabs are a promising alternative specimen for tuberculosis (TB) diagnosis, with high specificity (>98%) but lower sensitivity than sputum-based molecular tests. We investigated whether increased sample availability could offset lower sensitivity, re…
Johsuke Hara, Masaki Fujimura, Masahide Yasui, Reiko Takeda, Noriyuki Ohkura
Abstract Background We previously elucidated the fundamental pathophysiological features of various aetiologies of chronic cough, such as cough variant asthma, atopic cough, and sinobronchial syndrome. We also established a pathophysiological diagnostic procedure for aetiology id…
Yue Gao, Ling Hai, Yan Niu, Hong-Zhe Zhu, Rui Niu, et al.
**BACKGROUND:** Interleukin-27 (IL-27) in the pleural fluid has gained significant attention as a diagnostic biomarker for tuberculous pleural effusion (TPE); however, considerable variability exists across available studies. This systematic review and meta-analysis aimed to dete…
Hongling Wang, Liyan Jiang, Yang Xiao, Linlin Xu, Ning Zhang, et al.
**OBJECTIVES:** Systemic lupus erythematosus (SLE) is a life-threatening autoimmune disorder causing multi-organ damage. Current diagnostic methods are hindered by inadequate sensitivity and specificity of conventional biomarkers, which frequently delay diagnosis. Therefore, iden…
Miller AC, Cavanaugh JE, Arakkal AT, Koeneman SH, Polgreen PM
Background The incidence of diagnostic delays is unknown for many diseases and specific healthcare settings. Many existing methods to identify diagnostic delays are resource intensive or difficult to apply to different diseases or settings. Administrative and other real-world dat…
Fahad Nazir, Qiam Ud Din, Zubariah, Saba Afzal Shaikh, Ibrahim, et al.
Objective: To determine the diagnostic accuracy of Mantoux’s test and diagnostic BCG test in the diagnosis of tuberculosis in children by taking AFB (acid fast bacilli) sputum test as gold standard. Study Design: Cross Sectional study. Setting: Imran Idrees Teaching Hospital Sial…
Bachti Alisjahbana, Professor, MD, PhD
…ive TB cannot produce adequate sputum specimens, current TB diagnostics rely on sputum-based tests. Therefore, the use of near point-of-care (nPOC) or point-of-care (POC) non-sputum-based tests can potentially provide more accessible TB diagnosis and reduce delays. This CRCT is …
Broger T, Marx FM, Theron G, Marais BJ, Nicol MP, et al.
…le. Despite the roll-out of molecular WHO-recommended rapid diagnostics to replace sputum smear microscopy over the past decade, a large diagnostic gap remains. Of the estimated 10·6 million people who developed tuberculosis globally in 2022, more than 3·1 million were not diagno…
Weijia Lin, Zhi Liu, Yaping Zhang, Yanan Yu, Yang Liu, et al.
Objective: To investigate the clinical diagnostic value of TB-IGRA (Tuberculosis-Interferon Gamma Release Assay), PPD (Intradermal Tuberculin Test), TB-DNA-PCR (Tuberculosis-Deoxyribonucleic-Polymerase Chain Reaction) and ADA(Adenosine Aeaminase) in tuberculous pleural effusion. …
Raizada N, Khaparde SD, Swaminathan S, Sarin S, Salhotra VS, et al.
…te of the increasing availability of rapid high-sensitivity diagnostics in public and private sectors, majority of paediatric TB cases are empirically diagnosed, without laboratory confirmation. To address these diagnostic challenges, World Health Organization (WHO) has recommend…
Wen Rao, Dafu Wang, Xiaoxue Ma, Jian Zhou, Tingting Gong, et al.
**BACKGROUND:** Rifampicin-resistant tuberculosis (RR-TB) constitutes a persistent and formidable challenge for global TB control programs, as delayed diagnosis and treatment initiation contribute to transmission and poor outcomes. Molecular drug susceptibility testing (mDST) ena…
Huang JH, Chen H, Zhang ZC, Gu J, Yan L, et al.
Background and objective Cancer ratio (CR), which is defined as serum lactate dehydrogenase (LDH) to pleural fluid adenosine deaminase (ADA) ratio, has been reported to be a useful diagnostic marker for malignant pleural effusion (MPE). Whether its diagnostic accuracy is affected…
Adithya Cattamanchi, MD
…people with TB remain undiagnosed and 1 million die. Better diagnostics are essential to reducing the enormous burden of TB worldwide. The Rapid Research in Diagnostics Development for TB Network (R2D2 TB Network) brings together experts in TB care, technology assessment, diagnos…
Adithya Cattamanchi
…people with TB remain undiagnosed and 1 million die. Better diagnostics are essential to reducing the enormous burden of TB worldwide. The Assessing Diagnostics At Point-of-care for Tuberculosis (ADAPT) study seeks to reduce the burden of TB worldwide by evaluating faster, simple…