Showing 51–75 of 200 documents
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Qiuyue Song, Junlin Liu, Chunhua Wang
…s future development directions for tuberculosis laboratory diagnostics, aiming to provide valuable methodological references for the clinical diagnosis and treatment of tuberculosis.
Donovan J, Thu DDA, Phu NH, Dung VTM, Quang TP, et al.
…unding Wellcome Trust and the Foundation for Innovative New Diagnostics.
Thi Mai Nguyen, Emily Lai-Ho MacLean, Xiaomei Zhang, Sophia B Georghiou, Hui Xia, et al.
… to select 238 studies published between 2000 and 2024. The diagnostics options have expanded rapidly since 2020, with 27 nucleic acid amplification tests, eight line probe assays, five DNA microarrays, two targeted next-generation sequencing platforms, and two whole-genome seque…
Kumar V, Jorwal P, Soneja M, Sinha S, Nischal N, et al.
Background Early diagnosis and treatment of drug-resistant tuberculosis (TB) is crucial to halt the spread of drug resistance in the community. Aim The aim of the study was to compare rapid diagnostic tests (GeneXpert and line probe assay, LPA) with conventional liquid culture fo…
Usanee Anukool, P Phunpae, Chayada Sitthidet Tharinjaroen, B Butr-Indr, Sukanya Saikaew, et al.
Usanee Anukool,1,2 Ponrut Phunpae,1,2 Chayada Sitthidet Tharinjaroen,1,2 Bordin Butr-Indr,1,2 Sukanya Saikaew,1– 3 Nathiprada Netirat,4 Sorasak Intorasoot,1,2 Vorasak Suthachai,4 Khajornsak Tragoolpua,1,2 Angkana Chaiprasert5 1Division of Clinical Microbiology, Depa…
Andrii Dudnyk, Nadiia Tytarenko, Oksana Lytvyniuk, Olena Tolstova, Joan-Pau Millet, et al.
…luated the diagnostic accuracy of mfloDx MDR-TB assay (EMPE Diagnostics AB, Solna, Sweden) for simultaneous detection of resistance to isoniazid (INH) and rifampicin (RIF) compared to culture-based drug susceptibility test (DST). **DESIGN:** A prospective diagnostic accuracy stu…
Jacobs J, Hardy L, Semret M, Lunguya O, Phe T, et al.
…nity, such as the crucial role of regulatory frameworks for diagnostics and the educational profile required for a productive laboratory workforce in low-resource settings. Traditionally, clinical bacteriology laboratories have been a part of higher levels of care, and, as a resu…
Sarman Singh, Arti Shrivas
Tuberculosis (TB) is still a major health concern. However, each year more than one-third of all global TB cases remain undetected and unreported. On top of that, emergence of drug-resistant TB poses a major challenge. Therefore, a Reliable, Accessible, Cost-Effective, and Easy (…
Mohammadnabi N, Shamseddin J, Emadi M, Bodaghi AB, Varseh M, et al.
Background The infection caused by Mycobacterium tuberculosis arises from a complex interplay between the host immune system and the bacteria. Early and effective treatment of this disease is of great importance in order to prevent the emergence of drug-resistant strains. This ne…
Yangyi Zhang, Danni Li, Jiazhen Liu, Yuan Jiang, Xin Shen, et al.
**OBJECTIVES:** Fluoroquinolones (FQ) are one of the most prescribed broad-spectrum antibiotics and a cornerstone of tuberculosis (TB) treatment. TB patients may have had FQ resistance before treatment initiation. However, the association between pre-diagnostic FQ exposure and ac…
Singh UB, Verma Y, Jain R, Mukherjee A, Gautam H, et al.
Diagnosis of intra-thoracic tuberculosis (ITTB) in children is difficult due to the paucibacillary nature of the disease, the challenge in collecting appropriate specimens, and the low sensitivity of smear microscopy and culture. Culture and Xpert MTB/RIF provide higher diagnosti…
Saktiawati AMI, Vasiliu A, Saluzzo F, Akkerman OW
…wide. There is a critical need to tackle DR-TB by enhancing diagnostics and drug susceptibility testing (DST) capabilities, particularly for emerging DR-TB drugs. This endeavor is crucial to optimize the efficacy of new therapeutic regimens and prevent the resistance and overuse …
Nicholaus P. Mnyambwa
Tuberculosis remains one of the world’s deadliest infectious diseases in resource-limited settings, including Tanzania. Diagnostic challenges and minimal information on resistant tuberculosis complicate building effective management strategies. The current study employed whole ge…
Noura Mohammadnabi, Jebreil Shamseddin, Mobina Emadi, Ali Bayat Bodaghi, Mahdieh Varseh, et al.
BACKGROUND: The infection caused by Mycobacterium tuberculosis arises from a complex interplay between the host immune system and the bacteria. Early and effective treatment of this disease is of great importance in order to prevent the emergence of drug-resistant strains. This n…
Choudhuri B, Chakraborty M, Biswas P
Candida auris is an emerging multidrug-resistant fungal pathogen that has become a significant global health concern, particularly in critically ill patients within hospital settings. It is known for its high mortality rates, diagnostic challenges, and frequent misidentification,…
Bagheri M, Pormohammad A, Fardsanei F, Yadegari A, Arshadi M, et al.
Introduction: Pyrazinamide (PZA) susceptibility testing plays a critical role in determining the appropriate treatment regimens for multidrug-resistant tuberculosis. We conducted a systematic review and meta-analysis to evaluate the diagnostic accuracy of sequencing PZA susceptib…
Anukool U, Phunpae P, Tharinjaroen CS, Butr-Indr B, Saikaew S, et al.
Introduction Knowledge of the prevalence and distribution of multidrug-resistant tuberculosis (MDR-TB) genotypes in northern Thailand is still limited. An accurate, rapid, and cost-effective diagnostic of MDR-TB is crucial to improve treatment and control of increased MDR-TB. Mat…
Xiang-Dong Wang, Dongmei Niu, Wei Lv, Lei Wang, Chen-Yu Zhang, et al.
**OBJECTIVE:** Circulating non-coding small RNAs (sRNAs) have recently emerged as promising biomarkers for Mycobacterium tuberculosis (Mtb). However, little is known about the expression patterns and combined diagnostic potential of M. tuberculosis-derived sRNA (TB-sRNA) and endo…
Ness T, Van LH, Petermane I, Duarte R, Lange C, et al.
…TB drugs and regimens must be paired with implementation of diagnostics to ensure judicious use of resources and the best chance for improving TB worldwide.
Bjorn Moum, M.D Ph.D, Gunnar Bjune, M.D Ph.D
…eases. By using non-invasive rapid tests one wishes to make diagnostics available to resource poor settings. Ideally, referrals to invasive diagnostic procedures would decrease, thus liberating economic and staff resources. Furthermore, patients may avoid unnecessary, expensive a…
Sharif N, Ahmed D, Mahmood RT, Qasim Z, Khan SN, et al.
Tuberculosis is a communicable disease with high morbidity and mortality rates in developing countries. The study's primary objective is to compare conventional methods such as acid-fast bacillus (AFB) culture and microscopy with rapid diagnostic methods. The secondary objective …
World Health Organization. Regional Office for South-East Asia
The Xpert MTB/RIF assay is platform technology that has the potential for being used for screening for infectious and non-infectious diseases including HIV, malaria and detection of HPV for cervical cancer. The TB platform was completed in 2009 and is considered an important brea…
Swati B Gajbhiye, Madhavi V. Madkey, Dilip S Gedam
Background: Tuberculosis (TB) kills close to half a million Indians every year. Lack of reliable rapid diagnostic techniques for TB hampers timely diagnosis and leads to continued disease transmission, causing significant morbidity and mortality. The potential of newly recommende…
Beutler M, Plesnik S, Mihalic M, Olbrich L, Heinrich N, et al.
…ved to be suitable for quality control of PCR assays for TB diagnostics.
Beutler M, Homann AR, Mihalic M, Plesnik S, Niebling L, et al.
Xpert MTB/RIF testing has improved tuberculosis (TB) diagnostics and rifampicin (Rif) resistance testing worldwide. However, it has weaknesses, such as its restriction to Rif resistance testing and the inability to use extracted DNA for further testing. Herein, a holistic diagnos…