Showing 51–75 of 200 documents
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Aman Yadav, Yasha Hasija
Tuberculosis and sarcoidosis are clinically overlap-ping granulomatous diseases that present significant diagnostic challenges, particularly when distinguishing between their subtypes. Traditional diagnostic methods often lack specificity, leading to misclassification and subopti…
Hua Qiang Liu
Heat shock protein 16 kDa (HSP 16 kDa) is essential for the survival of latent Mycobacterium tuberculosis. Therefore, a peptide-MHC presentation of HSP 16 kDa could be a potential diagnostic and therapeutic target for latent tuberculosis (LTB). This study aimed to generate differ…
Qiu X, Tang Y, Zou R, Zeng Y, Yue Y, et al.
Tuberculin skin test and interferon-gamma release assay are not good at differentiating active tuberculosis from latent tuberculosis. Interferon-gamma-induced protein 10 (IP-10) has been widely used to detect tuberculosis infection. However, its values of discriminating active an…
Blauenfeldt T, Villar-Hernández R, García-García E, Latorre I, Holm LL, et al.
Interferon gamma (IFN-γ) release assays (IGRAs) are increasingly used to test for latent tuberculosis (TB) infection. Although highly specific, IGRAs have a relatively high false-negative rate in active TB patients. A more sensitive assay is needed. IFN-γ-induced protein 10 (IP-1…
Cai Q, Shen X, Li H, Yao C, Sun N, et al.
Background Mycobacterium tuberculosis (Mtb)-specific perforin were significantly increased in patients with tuberculosis. This study aims to evaluate the diagnosis value of Mtb-specific perforin in pediatric patients with tuberculosis. Methods Diagnostic performance of perforin l…
Shoupeng Ding, Chunxiao Huang, Jinghua Gao, Chun Bi, Yuyang Zhou, et al.
**OBJECTIVES:** The early diagnosis and immunoregulatory mechanisms of active tuberculosis (ATB) and latent tuberculosis infection (LTBI) remain unclear, and the role of metabolic genes in host-pathogen interactions requires further investigation. **METHODS:** Single-cell RNA se…
Erol S, Ciftci FA, Ciledag A, Kaya A, Kumbasar OO
Purpose Immunocompromised patients with latent tuberculosis infection (LTBI) are at high risk of progression to active tuberculosis. Detection and treatment of LTBI in this group of patients are very important to control active tuberculosis. Tuberculin skin test (TST) and interfe…
Yanling Wei, Lin Sun, Hongqiu Pan, Yifan Zhong, Hongyu Chen, et al.
**BACKGROUND:** Tuberculosis (TB) continues to be a major global health challenge, with difficulties in distinguishing active TB (ATB) from latent TB infection (LTBI) and identifying early biomarkers for diagnosis. **METHODS:** This study integrated single-cell RNA sequencing (s…
Uddin MKM, Islam A, Jabin MS, Alam T, Khair S, et al.
Background Around one-quarter of the global population has latent tuberculosis infection (LTBI). If left untreated, LTBI has 5-10% lifetime risk of developing into TB. Interferon-gamma release Assays (IGRAs) are more sensitive than the tuberculin skin test for LTBI detection. How…
Christianne Bourlon, Oscar Manuel Fierro-Angulo, Jesus A Garcia-Ramos, Rocío Camacho-Hernández, Roberta Demichelis, et al.
Introduction Latent tuberculosis infection (LTBI) affects one third of the world population. It is well known that patients with immunodeficiency are at a higher risk of developing active tuberculosis (ATBI). Hematopoietic stem cell transplant (HSCT) recipients have an incidence …
Koyuncu D, Niazi MKK, Tavolara T, Abeijon C, Ginese ML, et al.
More humans have died of tuberculosis (TB) than any other infectious disease and millions still die each year. Experts advocate for blood-based, serum protein biomarkers to help diagnose TB, which afflicts millions of people in high-burden countries. However, the protein biomarke…
Amitesh Gupta, Eshutosh Chandra, Shipra Anand, Naresh Kumar, Richa Arora, et al.
…andscape pertaining to latent tuberculosis infection (LTBI) diagnostics, with a particular emphasis on the global ramifications and the intricacies surrounding LTBI diagnosis and treatment. It accentuates the imperative of bolstering diagnostic, preventive, and treatment modaliti…
Ahmed MIM, Ziegler C, Held K, Dubinski I, Ley-Zaporozhan J, et al.
Tuberculosis (TB) epidemiology is changing in Western and Central Europe due to the rise in immigration and refugees fleeing high-TB-burden areas of war and devastation. The change in local demography and the lack of sensitive and specific TB diagnostic and monitoring tools, espe…
Bai Dai, Jing-Ying Liu, De-Bang Li, Zhi-Ming Wang, Xiu-Juan Chen
…ed diagnostic markers for LETB. Our study included clinical diagnostics, histological examinations, and transcriptomic analyses comparing differentially expressed genes (DEGs) among control, LETB, and active TB groups. We identified seven candidate genes (IFI30, HCK, SPI1, IL1B, …
Rajwinder Kaur, Varsha Sharma, Anju Kumari
Female genital tuberculosis (FGTB), a form of extrapulmonary tuberculosis caused by Mycobacterium tuberculosis (MTB), is an under-recognized but significant cause of female infertility, particularly in developing countries. It primarily spreads through the hematogenous route and …
Wattal C, Raveendran R
The diagnosis of childhood tuberculosis is a challenge due to the pauci-bacillary nature of infection and the difficulty in obtaining appropriate sample. In the past 2-3 decades, many new tests were introduced for the diagnosis of tuberculosis (TB) and some of them have been eval…
Kutame R, Boateng G, Adusi-Poku Y, Sorvor F, Antwi L, et al.
Interferon-gamma release assays (IGRAs) have gained attention for the diagnosis of latent tuberculosis infection (LTBI) due to their higher specificity compared to the tuberculin skin test (TST). However, the IGRA's performance varies across different populations. This study eval…
Calvin Young, Melissa Severn
Tuberculosis (TB) is a chronic communicable disease that primarily affects the respiratory system. It is caused by infection with Mycobacterium tuberculosis, a species of bacteria in the Mycobacteriaceae family. As much as 25% of the global population is estimated to have TB infe…
Akram Jokar, Maryam Mohammadi-Sichani, Moslem Jafarisani, Keivan Beheshti-Maal, Ali Hosseinzadeh
**BACKGROUND:** Tuberculosis (TB) remains a major global health burden, with latent and active infections contributing significantly to morbidity and mortality. Effective diagnostic methods, particularly for latent tuberculosis, are essential for improving disease control and pre…
Anne Ahrens Østergaard, Stephanie Bjerrum, Kristian Assing, Maria Bisgaard Borup, Rasmus Bank Lynggaard, et al.
As regulators of innate and adaptive immunity, microRNAs (miRNAs) could aid in the discrimination between tuberculosis disease (TB) and (latent) TB infection (TBI). We analysed 754 circulating miRNAs in participants diagnosed with TB and TBI using TaqMan™ Advanced miRNA Hu…
Kim A, Park KJ, Kim YS, Cho SN, Dockrell HM, et al.
…ific antigen can provide useful information for improved TB diagnostics. The antigen may be developed as a diagnostic marker or a vaccine candidate, particularly in regions where the M. tb Beijing/K strain is endemic.
Kanz Elkhiyari, Balazs Kaszala, Asma Hashim, Yuvraj Rallapalli, Jeremiah Khayumbi, et al.
Lack of accurate yet inexpensive diagnostics remains a critical bottleneck in the control and elimination of tuberculosis (TB). The interferon-gamma release assay (IGRA), which involves measurement of the release of the cytokine, interferon-gamma (IFN-γ), in blood samples s…
Joan Cayla, MD, Henrik Aggerbeck, M. Sc.
…C-Tb test. The TESEC-06 trial is an open comparison of the diagnostics performance of C-Tb compared to QuantiFERON®-TB Gold In-Tube, in combination with a double-blind randomized split-body safety assessment of C-Tb versus Tuberculin PPD RT23 SSI. The trial is designed to addre…
Young C, Severn M
Tuberculosis (TB) is a chronic communicable disease that primarily affects the respiratory system. It is caused by infection with Mycobacterium tuberculosis, a species of bacteria in the Mycobacteriaceae family. As much as 25% of the global population is estimated to have TB infe…
Araujo Z, de Waard JH, Camargo M, Lopez-Ramos JE, de Larrea CF, et al.
Diagnosis and treatment of active tuberculosis (ATB) as well as latent tuberculosis infection (LTBI) are required for effective tuberculosis (TB) control, especially in TB endemic area. The usefulness of conventional tests to distinguish between ATB and LTBI has remained challeng…