Showing 51–75 of 200 documents
Sorted by hybrid relevance (keyword + semantic via RRF)
Zhou R, Qiu X, Ying J, Yue Y, Ruan T, et al.
Background and aim Abdominal tuberculosis (TB) is a common type of extrapulmonary TB with an insidious onset and non-specific symptoms. Adenosine deaminase (ADA) levels increase rapidly in the early stages of abdominal TB. However, it remains unclear whether ADA serves as a diagn…
Pervez A, Hasan SU, Hamza M, Asghar S, Qaiser MH, et al.
Tuberculous pericarditis (TBP) is a relatively uncommon but potentially fatal extrapulmonary manifestation of tuberculosis. Despite its severity, there is no universally accepted gold standard diagnostic test for TBP currently. The objective of this study is to compare the diagno…
Yu Li, Hongjuan Wei, Limei Sun, Dongsong Tang, Tiantian Wang, et al.
…cal diagnostic approaches. Recent advancements in molecular diagnostics have revolutionized tuberculosis detection in this vulnerable population. This review critically evaluates current laboratory methods for MTB detection in HIV/MTB co-infected individuals, analyzing their diag…
Antel K, Levetan C, Mohamed Z, Louw VJ, Oosthuizen J, et al.
Background Little is known about the pathway to diagnosis of lymphoma in Sub-Saharan Africa, despite the increased risk of lymphoma in people living with HIV (PLHIV). The challenges of diagnosis in this setting include diagnostic confusion with extrapulmonary tuberculosis (EPTB),…
Olbrich L, Verghese VP, Franckling-Smith Z, Sabi I, Ntinginya NE, et al.
Background Childhood tuberculosis remains a major cause of morbidity and mortality in part due to missed diagnosis. Diagnostic methods with enhanced sensitivity using easy-to-obtain specimens are needed. We aimed to assess the diagnostic accuracy of the Cepheid Mycobacterium tube…
Timur Gonchar, Mauro Sidney De Robertis, Carola Güther, Madlen Löbel, Tobias Kleemann
…ch as Crohn's disease (CD) or GI malignancies. Conventional diagnostics, like direct microscopy and culture, are often inconclusive or slow, delaying treatment. In Germany, a low-incidence country, GI TB is underrecognized. Rising migration has led to a resurgence of TB cases, in…
Wen A, Leng EL, Liu SM, Zhou YL, Cao WF, et al.
Background In this study, we evaluated and compared the accuracy of blood and cerebrospinal fluid (CSF) interferon release tests [interferon-gamma release assays (IGRAs)] in the diagnosis of tuberculous meningitis (TBM) by a meta-analysis of the relevant literature. Methods We se…
Tamer A. Addissouky
…Short conclusion A multifaceted approach combining advanced diagnostics, optimized therapeutics, and strategic prevention is essential for addressing the global ITB burden. Future research should focus on developing point-of-care diagnostics, personalized treatment protocols, and…
Babak Pourakbari, Hani Rostami Rad, Maryam Sotoudeh, Reihaneh Hosseinpour Sadeghi, Shima Mahmoudi, et al.
…s contribute to disease localization. Integrating molecular diagnostics and immune profiling can enhance early detection and guide better clinical management of childhood TB.
Qingwen Lin, Wenhua Fang, Kengna Fan, Weiqing Zhang, Xiaxia Qiu, et al.
Tuberculous meningitis (TBM) leads to severe disability and mortality rates, making early diagnosis critical. However, it is challenging to distinguish it from other common forms of non-tuberculous meningitis (non-TBM), including bacterial meningitis, cryptococcal meningitis, and…
Wang C, Forsman LD, Wang S, Wang S, Shao G, et al.
Objectives To evaluate the performance of GeneXpert MTB/RIF (Xpert) for tuberculous meningitis (TBM) and to identify additional indicators to improve diagnostic accuracy. Methods An accuracy study was conducted. During 2011-2019, 243 TBM with 140 non-TBM in three TB-designated fa…
Sohail Hussain, Faiza Nafees Khan, Aimen Noor Ul Ain, Momina Shahid, Imtiaz Begum, et al.
Abstract Background Tuberculosis (TB) of the abdomen is a rare form of extrapulmonary TB with indeterminate symptoms that are commonly mistaken for malignancies, leading to substantial diagnostic problems. This report describes the intricacies of diagnosing abdominal TB and empha…
Imane Chaoui, Samir Taoudi, Amal Oudghiri, J. Benamor, J.E. Bourkadi, et al.
…a very common form of extrapulmonary tuberculosis (TB). pTB diagnostics represents a major burning challenge worldwide due to the limitations of available conventional diagnostic tools. These latter include microscopic examination of the pleural fluid for acid-fast bacilli, mycob…
Leeberk Raja Inbaraj, Vignes Anand Srinivasalu, Mukesh Kumar Sathya Narayanan, Adhin Bhaskar, Jefferson Daniel, et al.
…is (TB-LAMP), are among the molecular WHO-recommended rapid diagnostics and can provide results within a few hours, even in resource-limited settings. We aimed to synthesise evidence on the accuracy of these tests for the detection of pulmonary and extrapulmonary tuberculosis, to…
Zhao C, Song C, Yang S, Huang A, Lin Y, et al.
Objective To investigate the diagnostic efficacy of nanopore sequencing technology in tuberculous meningitis (TBM). Methods Cerebrospinal fluid samples were collected from patients for acid-fast staining microscopy, Mycobacterium tuberculosis solid culture, DNA detection, and nan…
Muhammad Ahmad Raza, Muazzam Tufail, Laamia Altuf, Kinza Chaudhary, Sidra Ghazanfar, et al.
Background: Central nervous system infections (CNSIs) are a significant cause of morbidity and mortality globally. Accurate diagnosis is crucial for effective management and improved outcomes.Objective: To determine the diagnostic accuracy of magnetic resonance imaging (MRI) for …
Seiwon Lee
It is intended for patients who have been admitted to the outpatient or emergency room or are hospitalized For patients who diagnose pulmonary tuberculosis or extrapulmonary tuberculosis using Xpert TB/RIF, additionally, diagnose pulmonary tuberculosis or extrapulmonary tuberculo…
Yadav P, Mahour P, Agarwal A, Garg A
Background As centuries and millennia passed, tuberculosis remains the major health threat for millions of people. Due to this resurgence of tuberculosis, scientists around the globe have intensified their research efforts to curb down the transmission of this disease and that is…
Ashish Soni, Indu Sharma, Srishti Joshi Sharma, Nimisha Dandriyal, Kriti Novel, et al.
The causative agent of tuberculosis (TB) is Mycobacterium tuberculosis, one of the global health concerns with morbidity and mortality. TB presents in two forms; pulmonary tuberculosis (PTB) affects the lungs, and extrapulmonary tuberculosis (EPTB) affects organs other than the l…
Nishal N, Arjun P, Arjun R, Ameer KA, Nair S, et al.
Background Extrapulmonary Tuberculosis (EPTB) accounts for 15%-53% of all TB cases. In recent years, cartridge-based nucleic acid amplification test (CBNAAT) has emerged as an important diagnostic tool since the diagnostic yield is higher. We conducted this study to evaluate the …
Gao M, Wu Q, Wang X, Sun X, Li M, et al.
Objective The purpose of this study was to investigate the diagnostic value of urine lipoarabinomannan (LAM) detection based on chemiluminescence assay for pulmonary tuberculosis (PTB) and extrapulmonary tuberculosis (EPTB) in HIV-negative individuals. Methods A total of 215 pati…
Mohanty M, Mishra B, Jain M, Karaniveed Puthiyapura L
Background Osteoarticular tuberculosis (OATB) is a severe form of extrapulmonary tuberculosis (TB), which causes notable morbidity and warrants a high index of suspicion for prompt management. The diagnosis of OATB poses a challenge, because of the difficulty of collecting the sa…
Jiaxing Tan, Yan Yin, Guang Hua, Lili Wang
This study aims to observe and analyze the diagnostic value of T-cell enzyme linked immunospot assay for tuberculosis infection during the diagnosis of pulmonary tuberculosis and extrapulmonary tuberculosis. The study objects were 200 cases of tuberculosis patients in the outpati…
Shen Y, Fang L, Ye B, Yu G
Background Abdominal tuberculosis is a severe extrapulmonary tuberculosis, which can lead to serious complications. Early diagnosis and treatment are very important for the prognosis and the diagnosis of abdominal tuberculosis is still difficult. This study aims to evaluate the d…
Pormohammad A, Nasiri MJ, McHugh TD, Riahi SM, Bahr NC
The diagnosis of tuberculous meningitis (TBM) is difficult and poses a significant challenge to physicians worldwide. Recently, nucleic acid amplification (NAA) tests have shown promise for the diagnosis of TBM, although their performance has been variable. We undertook a systema…