Showing 51–75 of 200 documents
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Kazakova A, Zhelnov P, Sidorov R, Rogova A, Vasileva O, et al.
…prehensively identify and provide an overview of in vivo or clinical studies of nucleic acids (NA)-based vaccines against TB we included human or animal studies of NA vaccines for the prevention or treatment of TB and excluded in vitro or in silico research, studies of microorgan…
Du Y, Qiu C, Chen X, Wang J, Jing W, et al.
… reflecting superior antimicrobial activity against MDR-TB. Clinical trials registration Chinese Clinical Trial Registry ChiCTR 1800020391.
Sun W, Wu Z, Zhou Y, Xia F, Tang Q, et al.
…ld be expected to be developed into a short-course regimen. Clinical trials registration China Clinical Trial Registry ChiCTR-OPC-16009380.
Fairall L, Petersen I, Zani B, Folb N, Georgeu-Pepper D, et al.
… Nations Programme on HIV/AIDS (UNAIDS) targets. The CobALT trial aims to provide evidence on the effectiveness and cost-effectiveness of scalable interventions to reduce the treatment gap posed by the growing burden of depression among adults on lifelong ART. Methods The study d…
Аlbert R. Muslimov, Pavel Zhelnov
…erculosis based on nucleic acids in development, both in preclinical and clinical studies, if any, and to provide an overview of their formulations of choice.METHODSEligibility criteria: Records will be eligible for inclusion if they report any (in vitro, in silico, or in vivo) d…
Xu Z, Chen W, Li X
… life of patients with pulmonary tuberculosis, with obvious clinical efficacy. Trial registration Chinese Clinical Trial Registry ChiCTR2100048983.
Ohno S, Umebayashi I, Matsukawa M, Goto T, Yano T
…er, the long-term safety profile and efficacy in real-world clinical settings in patients with RUBD have not been fully clarified. The BRIGHT study, a prospective, large-scale, long-term postmarketing surveillance (PMS) study, was conducted to investigate the long-term safety and…
Hayley A. Scott, Lisa G. Wood, Evan J. Williams, Natasha Weaver, John W. Upham
…cipants (75% female; mean age, 33.4 [9.9] yr) completed the trial. Moderate exercise induced a significant reduction in sputum eosinophil count (−173 [−337 to −10]; P = 0.032) and sputum percentage eosinophils (−2.2 [−4.9 to 0.5]; P = 0.049) relative to control. Vigorous exercise…
Moosa MS, Maartens G, Gunter H, Allie S, Chughlay MF, et al.
…We conducted a randomized, double-blind, placebo-controlled trial to assess the efficacy of intravenous NAC in hospitalized adult patients with anti-tuberculosis drug-induced liver injury (AT-DILI). The primary endpoint was time for serum alanine aminotransferase (ALT) to fall be…
Babalwa Zani, Lara Fairall, Inge Petersen, Naomi Folb, Arvin Bhana, et al.
…s a secondary analysis of data from a randomised controlled trial of depression management in 2002 adults receiving ART. We investigated the effects of sociodemographic characteristics, comorbidities, depression symptoms (Patient Health Questionnaire-9 (PHQ-9)), functional disabi…
Babalwa Zani, Lara Fairall, Inge Petersen, Naomi Folb, Arvin Bhana, et al.
…s a secondary analysis of data from a randomised controlled trial of depression management in 2002 adults receiving ART. We investigated the effects of sociodemographic characteristics, comorbidities, depression symptoms (Patient Health Questionnaire-9 (PHQ-9)), functional disabi…
Baluku JB, Ronald O, Bagasha P, Okello E, Bongomin F
…Web of Science, the Cochrane Central Register of Controlled Trials, mRCTs, Clinical trials.gov, and International Clinical Trials Registry Platform from inception to 31st December 2021. Among 110 eligible studies, 79 (238,316 participants) were included in the meta-analysis for s…
Zeguang Zheng, Kai Yang, Geoffrey Liu, Xiuhua Fu, Huijie He, et al.
…nter, randomized, double-blind, placebo-controlled, phase 3 trial at 19 centers in China. Hospitalized adult patients with mucopurulent sputum and expectoration difficulty were recruited. Patients were randomized by 1:1 to receive inhalation of either ambroxol hydrochloride solut…
William J Burman, M Florencia Martins, David Flynn, James Johnston, Pranay Sinha, et al.
…atment completion but have not been the focus of late-phase clinical trials. We performed a scoping review to identify interventions to improve the safety and tolerability of rifampin-susceptible tuberculosis. Our objective was to determine what interventions have been evaluated …
Shi W, Hu Y, Zheng X, Ning Z, Wu M, et al.
…n alterations in gut microbiota composition and unfavorable clinical outcomes. Methods The study is a multicenter, observational prospective cohort study. Three study sites are purposively selected in the western (Sichuan Province) and eastern (Jiangsu Province and Shanghai) part…
Millard JD, Mackay EA, Bonnett LJ, Davies GR
… Methods We will search for randomised and quasi-randomised clinical trials in adult participants with and without the inclusion of PZA in TB treatment regimens in the Cochrane infectious diseases group's trials register, Cochrane central register of controlled trials (CENTRAL), …
Hills NK, Lyimo J, Nahid P, Savic RM, Lienhardt C, et al.
…osis (TB). However, the current practice in TB therapeutics trials is to use composite binary outcomes, which in the absence of standardization may inflate false positive and negative errors in evaluating regimens. The lack of standardization of outcomes is a barrier to the ident…
Xie F, Duan Z, Zeng W, Xie S, Xie M, et al.
… 159 CAP patients to assess the diagnostic performance of a clinical metagenomics assay and its impact on clinical management and patient outcomes. When compared to other techniques, clinical metagenomics detected more pathogens in more CAP cases, and identified a substantial num…
Manal Arshad Malik, Aleena Kamran, Dua Ahsan, Aafia Amjad, Sara Moatter, et al.
…d across major databases, including PubMed, Google Scholar, ClinicalTrials.gov, the WHO International Clinical Trials Registry Platform, and the ISRCTN Registry. The search strategy used terms like ("tubercular meningitis" OR "TBM" OR "TB meningitis") AND ("diagnosis" OR "treatme…
Ye Q, Wang H, Xia X, Zhou C, Liu Z, et al.
…ls (DPSCs) in treating severe pneumonia caused by COVID-19. Trial design This is a single centre, two arm ratio 1:1, triple blinded, randomized, placebo-controlled, parallel group, clinical trial. Participants Twenty serious COVID-19 cases will be enrolled in the trial from April…
Rudolf F, Abate E, Moges B, Mendes AM, Mengistu MY, et al.
Background The Bandim TBscore is a clinical score that predicts treatment outcome in Tuberculosis (TB) patients and proved useful as an indicator of which healthcare-seeking adults to refer for sputum smear microcopy. We aimed to test in a randomized trial if the TBscore could be…
Human Sciences Research Council
…his pragmatic, open-label, individual randomised controlled trial was done in nine clinics in Johannesburg, South Africa. Participants (aged ≥18 years) undergoing investigation for tuberculosis were randomly assigned (1:1) to the intervention group or control group (standard of c…
Jagannath Purushothama
…ebo controlled, block- randomized, double-arm, single blind trial will be experimented between March 2019 and August 2022 in Mangaluru, India, with a sample size of 300 in both the arms. The intervention group will be prescribed with nicotine polacrilex chewing gums along with br…
Inbaraj LR, Manesh A, Ponnuraja C, Bhaskar A, Srinivasalu VA, et al.
… in the field of TBM over the last two decades and only few trials have evaluated a composite of these strategies in the overall outcomes of TBM. Methods An open label, parallel arms, randomized controlled superiority trial will be conducted among 372 participants across 6 sites …
Bjerrum S, Schiller I, Dendukuri N, Kohli M, Nathavitharana RR, et al.
…d symptoms).The proposed role for LF-LAM is as an add on to clinical judgement and with other tests to assist in diagnosing tuberculosis. Search methods We searched the Cochrane Infectious Diseases Group Specialized Register; MEDLINE, Embase, Science Citation Index, Web of Scienc…