Showing 51–75 of 200 documents
Sorted by hybrid relevance (keyword + semantic via RRF)
Komine-Aizawa S, Mizuno S, Matsuo K, Namiki T, Hayakawa S, et al.
The incidence of infections with nontuberculous mycobacteria (NTM) has been increasing worldwide. The emergence of multidrug-resistant NTM is a serious clinical concern, and a vaccine for NTM has not yet been developed. We previously developed a new recombinant Bacillus Calmette-…
Aishwarya Venkataraman, MRCPCH
…cille Calmette Guerin (BCG) vaccine is one of the most used vaccines of the world, to reduce the risks of natural tuberculous infection. The efficacy of BCG vaccination in newborns is well known and has a documented protective effect against meningitis and disseminated TB in chil…
Modipane L, Reva O, Magazi BT, Antiabong JF, Osei Sekyere J, et al.
Background Mycobacterium bovis BCG is a live, attenuated tuberculosis vaccine. While the vaccine protects infants from tuberculosis, complications including disseminated infections have been reported following vaccination. Genetically diverse BCG sub-strains now exist following c…
Russo G, Sgroi G, Parasiliti Palumbo GA, Pennisi M, Juarez MA, et al.
… the immunity induced by specific drugs such as therapeutic vaccines and antibiotics. Results Here, we present how UISS accurately simulates tuberculosis dynamics and its interaction within the immune system, and how it predicts the efficacy of the combined action of isoniazid an…
Valentina Monaci, Davide Oldrini, Fabiola Giusti, Luigia Cappelli, Roberta Cozzi, et al.
Self-assembling protein nanoparticles (NPs) offer a versatile platform to enhance antigen immunogenicity through a multivalent display.(Kp) is a critical multidrug-resistant pathogen for which no licensed vaccine exists, posing a significant global health threat. This study aimed…
О. М. Raznatovska, A. S. Moskaliuk, Тетяна Анатоліївна Грекова, L. I. Chernyshоva, O. O. Pushnova, et al.
BACKGROUND. The World Health Organization (WHO) reports an unknown contact history of pediatric tuberculosis (TB), especially in children younger than 5 years old. Tracing pediatric household contacts of patients with multidrug-resistant TB (MDR-TB) is considered to be a highly e…
Agulló-Ros I, Burucúa MM, Cheuquepán FA, Domínguez M, Sevilla IA, et al.
…ever, BCG presents several safety concerns inherent to live vaccines. To overcome these limitations, exploring alternative vaccine candidates that do not incorporate live mycobacteria is crucial. This study aimed to evaluate and compare the immunostimulatory potential of two cand…
Ana Alvarez, Mobeen H. Rathore
Data from clinical and epidemiological studies have led to several new recommendations in the areas of diagnosis and treatment of pediatric tuberculosis in the past few years. Due to the low incidence of tuberculosis in the United States, many primary care providers may not be fa…
Daniel Mashiach, Justin Shon, Raquel Mashiach, Gregory Ayzenberg, Osnat Barazani, et al.
Pediatric tuberculosis (TB) remains a critically underrecognized contributor to global childhood morbidity and mortality, with the highest burden concentrated in low-resource settings. Although children comprise a minority of overall TB cases, mortality is disproportionately high…
Afifah Machlaurin
Tuberculosis (TB) was the leading cause of death due to infectious diseases. In Indonesia, TB incidence and mortality are still very high. Immediate steps to scale-up preventive, diagnostic, and treatment services for TB, specifically among hard-to-reach populations, were priorit…
Villamizar-Mogotocoro AF, Vargas-Méndez LY, Kouznetsov VV
…enormous efforts in drug research on TB treatment including vaccines and diagnostics investigations, this old contagious, infectious disease is still a major public health problem. The goal of elimination of epidemic TB disease by 2035 will not be achieved without combined strate…
Saumya Sagar, Anupam Prakash
…rch and development for better diagnostics, treatments, and vaccines often lag. For example, India is one of the major countries carrying the world’s filariasis burden, mostly spread across the western and eastern coastal borders. Yet, just recently, the national programme has be…
Anna Cristina Calçada Carvalho, Afrânio Lineu Kritski
Tuberculosis in children (younger than 15 years) has often been considered a minor problem by national tuberculosis programmes. The low bacterial load of tuberculosis in children, which confers a lower risk of disease transmission,1Marais BJ Gie RP Schaaf HS et al.The natural his…
Pei-Yao Zhai, Xiao Zang, Ting Jiang, Jian Feng, Bin Zhang, et al.
**BACKGROUND:** China faces high burden of multidrug-resistant or rifampicin-resistant tuberculosis (MDR/RR-TB). We aimed to evaluate the impacts of Vaccae vaccination and enhanced drug-resistant TB (DR-TB) management strategies. **METHODS:** Using a compartmental model calibrat…
Basu Roy R, Whittaker E, Seddon JA, Kampmann B
…ns are necessary to guide development of novel tuberculosis vaccines that could facilitate the achievement of WHO's goal to eliminate deaths from tuberculosis in childhood.
Mockeliunas, Laurynas
Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis. Each year, more than 10 million people are estimated to develop TB, and over 1.2 million die from the disease, and resistance to drugs is a major challenge. Another infectious disease, coronavirus di…
Z.I. Pіskur, O.P. Kostyk, M.І. Sakhelashvili, L.І. Pylypiv, O.M. Shvets, et al.
Objective — to analyze the peculiarities of detection and course of various clinical forms of extrapulmonary tuberculosis (EPTB), the profile of drug resistance of the Mycobacterium tuberculosis (MBT) among children of different ages. Materials and methods. We retrospectively an…
Arega AM, Mahapatra RK
…y in charge of TB pathogenesis and encounter many drugs and vaccines. Therefore, in this review we provide an insight into a comprehensive study concerning the importance of cell envelope glycoconjugates and hypothetical proteins, the impact of post-translational modification, an…
Gülşen Akkoç, Seyhan Yılmaz, Sevgi Aslan Tuncay, Aylin Dizi Işık, Pınar Canizci Erdemli, et al.
Background: Tuberculosis (TB) remains a major cause of morbidity and mortality, with children primarily infected through close contact with adults. Data on household transmission in children in Türkiye are limited.Objective: This study aimed to determine the prevalence of latent …
Farman M, Shehzad A, Nisar KS, Hincal E, Akgul A
Background Tuberculosis, a global health concern, was anticipated to grow to 10.6 million new cases by 2021, with an increase in multidrug-resistant tuberculosis. Despite 1.6 million deaths in 2021, present treatments save millions of lives, and tuberculosis may overtake COVID-19…
Mohau S. Makatsa
Tuberculosis (TB) remains the infectious disease causing the greatest global mortality, with an estimated 10 million incident cases of TB and 1.45 million deaths in 2018. Although there is a cure for TB, the success of the treatment is hampered by multidrug resistant TB and HIV i…
Lin Y, Dong Y, Gao Y, Shi R, Li Y, et al.
…erefore, the development of safe and effective tuberculosis vaccines is an urgent issue. In this study, we identified cytotoxic T lymphocyte epitopes on drug resistance-associated membrane protein efflux pumps of MTB, the ATP-binding cassette and the major facilitator superfamili…
Owusu SK
…ins the only vaccine for TB prevention, there are candidate vaccines that target infants and adolescents.
Kamath Madhusudhana
…um tuberculosis. Thatis about 2 billion people. Several new vaccines will pass Phase I clinical trials in the next few years. Thispaper briefly summarizes past and present challenges to developing a vaccine against tuberculosis as well astreating tuberculosis. TB is a pathogen th…
Weng S, Li Q, Zhang T, Lin T, He Y, et al.
Tuberculosis (TB) is a major global health threat despite its virtual elimination in developed countries. Issues such as drug accessibility, emergence of multidrug-resistant strains, and limitations of the current BCG vaccine highlight the urgent need for more effective TB contro…