Showing 51–75 of 184 documents
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Beatrice Napoli
Tuberculosis (TB) still represents one of the leading diseases globally, causing significant morbidity and mortality. Among the possible approaches to the disease, vaccination has been considered the most important measure for its prevention. Nowadays, it comprises the use of the…
Lyudmila Ilyinichna Kaspruk
According to the formula presented by WHO, it is possible to prevent and stop the development of an epidemic of an infectious disease only when at least 90 % of the population is covered by vaccination against this type of pathogen, provided that at least 95 % of vaccinated perso…
Göran Wennergren, Hugo Lagercrantz
Arvid Wallgren studied medicine at Uppsala and defended his thesis on tuberculosis there. At the age of 32, he was appointed consultant physician at Gothenburg Children's Hospital. The recruitment of Wallgren proved to be quite fortunate. Wallgren developed and introduced the BCG…
Tamanna Bordoloi, Kiran Bala, Jaya Biswas, Neha Nityadarshini, Raunak Bir, et al.
Introduction Tuberculosis (TB) and COVID-19 are highly transmissible respiratory diseases. The sequel of development of active TB after COVID-19 disease has been hypothesized to increase due to many reasons. We aimed to explore the association between COVID-19 infection, COVID-19…
Rafaela Cayres de Sa Mariusso, GYMAIMA YASMIN JOÃO NEHME, Ana Luíza Bezerra, Vanessa Ricardo Ivanesciuc Braga, Gabriela Castro Leite, et al.
Tuberculous meningitis (TBM) is caused by Mycobacterium tuberculosis and accounts for 5% of extrapulmonary tuberculosis cases. Children under 5 years old who are not immunized with the BCG vaccine and individuals with comorbidities are at higher risk for TBM. Incidence and vaccin…
Shen L, Frencher J, Huang D, Wang W, Yang E, et al.
…sets, and provide an approach to creating more effective TB vaccines.
Yang TL, Lee CM, Lee KL, Yen TY, Lu CY, et al.
Purpose To investigate the clinical feature of tuberculosis and BCG adverse effects in children and to examine whether delayed BCG vaccination changes the incidence of BCG osteomyelitis. Methods We analyzed patients younger than 18 years with tuberculosis or BCG-associated advers…
Michèle Tameris, Sara Barja, Virginie Rozot, Claire Imbratta, Munyaradzi Musvosvi, et al.
<h3>Background</h3> New safe and effective TB vaccine strategies to replace infant BCG vaccination are needed urgently. We evaluated the safety, reactogenicity and immunogenicity of three doses of the live-attenuated Mycobacterium tuberculosis (Mtb) vaccine candidate, MTBVAC, in …
Zhou F, Zhang D
Bacillus Calmette-Guerin (BCG), the only current vaccine against tuberculosis (TB) that is licensed in clinics, successfully protects infants and young children against several TB types, such as TB meningitis and miliary TB, but it is ineffective in protecting adolescents and adu…
Emad Siddiqui, Tooba Siddiqui, Abdus Salam Khan
Abstract Background Tuberculosis (TB), a preventable airborne infectious disease, early detection is essential to improve health outcomes. Extent of childhood tuberculosis is unknown and is estimated to be around 6% of all incidences. Diagnosis of pediatric tuberculosis is always…
Gabriela Lopes Viana, Sophie Sayeg Blachman, Letícia Lima e Silva, Sofia Nahas Mazzei, Renata Fonseca Inácio Osti, et al.
Tuberculosis (TB) is an infectious disease caused by the bacterium Mycobacterium tuberculosis . Although it affects all age groups, children aged 0 to 9 years are particularly vulnerable due to immunological immaturity, which favors progression to extrapulmonary forms of the dise…
Shabariah R, Hatta M, Idris I, Santoso A, Patellongi I, et al.
The formation of a scar after Mycobacterium bovis Bacillus Calmette-Guérin ( BCG) vaccination influences the effectiveness of protection against Mycobacterium tuberculosis (MTB) infection. The innate immunity plays a critical role both in the pathophysiology of tuberculosis (TB) …
Tameris M, Rozot V, Imbratta C, Geldenhuys H, Mendelsohn SC, et al.
Background Safer and more effective tuberculosis (TB) vaccines than Bacille Calmette Guérin (BCG) are needed. We evaluated the safety, reactogenicity, and immunogenicity of three dose levels of the live-attenuated Mycobacterium tuberculosis (Mtb) vaccine, MTBVAC, compared to BCG,…
Qibin Liu, Xiyong Dai, Shuang Wei
Bacille Calmette-Guérin (BCG) remains the only licensed vaccine against tuberculosis (TB), administered to >100 million neonates annually. It confers approximately 70-80% protection against tuberculous meningitis and miliary TB in early childhood, under-pinning its continued…
Regita Thaalanie Yolanda Sukoco, Nugraha Sutadipura, Nurul Romadhona
…ound for 80 years and is one of the most widely used of all vaccines today. This vaccine can prevent the occurrence of TB meningitis and disseminated in children. There are several factors that affect the effectiveness of BCG immunization that can affect the success of immunizati…
Du J, Su Y, Wang R, Dong E, Cao Y, et al.
…-CoV-2 makes the protective efficiency of COVID-19-specific vaccines an unprecedented challenge. Therefore, it has been hypothesized that BCG-induced trained immunity might protect against COVID-19 infection. This study comprehensively described BCG-induced nonspecific and specif…
Kerry L Hilligan, Patricia A Darrah, Robert A Seder, Alan Sher
…jor strategy in the development of more effective BCG-based vaccines and immunotherapies.
Shital Patil, Sonal Ray, Akhilesh Anjan
Tuberculosis (TB) is one of the leading causes of mortality in children worldwide, but there remain significant challenges in diagnosing and treating TB infection and disease. Tuberculous (TB) meningitis is the commonest infectious disease of the central nervous system in paediat…
A Yu Ivoylov, Mihail M. Polunin, N A Mileshina, S S Osipenkov, A. N. Radtsig
Nowadays, the incidence of tuberculosis remains high all over the world, despite the vaccination, medical support, social policy. The main reasons for this are the high level of migration, the prevalence of bad habits, the prevalence of immunodeficiency conditions, the formation …
Dey RJ, Dey B, Singh AK, Praharaj M, Bishai W
Background Stimulator of interferon genes (STING) is a key cytosolic receptor for small nucleotides and plays a key role in anticancer and antiviral immunity. Cyclic dinucleotide STING agonists may comprise a novel class of vaccine adjuvants capable of inducing cellular immune re…
Abstract Background Tuberculosis (TB) is a disease caused by Mycobacterium tuberculosis complex, mainly by M. tuberculosis. Annually, 1 million children develop TB disease and many more present a latent form of infection. The objective of this study is to define the epidemiologic…
D K Runyan, K Banu, N Thilothammal, P V Krishnamurthy
The reported efficacy of BCG vaccine in preventing pulmonary tuberculosis varies from 0-80% ; however, its efficacy in preventing tuberculous meningitis ranges from 52%-84%. A case-control study was conducted to assess the efficacy of BCG in preventing tuberculous meningitis in c…
Enrique G. Villarreal, Ricardo J. Estrada-Mendizábal, Emilia Ramos-Barrera, Pablo D Treviño-Valdez, Oscar Tamez‐Rivera
Abstract Background Tuberculosis (TB) is a disease caused by Mycobacterium tuberculosis complex, mainly by M. tuberculosis. Annually, 1 million children develop TB disease and many more present a latent form of infection. The objective of this study is to define the epidemiologic…
Donald P, Kaufmann S, Thee S, Mandalakas AM, Lange C
During the 1930 Lübeck Mycobacterium bovis bacille Calmette-Guérin (BCG) disaster, 251 neonates received three oral BCG doses accidentally contaminated by virulent Mycobacterium tuberculosis ; 67 (26.7%) infants died of tuberculosis. BCG reversion to pathogenicity did not occur. …
Marcus James Renshaw, Pete John Webster
Extrapulmonary Tuberculosis (EPTB) can affect many organ systems, including the gastrointestinal (GI) tract. Here, it may manifest as intestinal, peritoneal, hepato-pancreato-biliary TB, or as TB lymphadenitis. We report a case of small bowel obstruction secondary to peritoneal T…