Showing 51–75 of 200 documents
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Liu H, Zhu H, Fu L, Zhang W, Chen X, et al.
…ein synthesis inhibition, may undermine the efficacy of LZD regimens, and oxazolidinones with higher efficacy and lower toxicity during prolonged administration are needed. OTB-658 is an oxazolidinone anti-TB candidate derived from LZD that could replace LZD in TB treatment. We p…
Pirmahmadzoda B, Hann K, Akopyan K, Grigoryan R, Geliukh E, et al.
…, and Tajikistan did so in 2013 and 2017. Novel and adapted regimens included individual regimens for RR/MDR, XDR (with and without Bedaquiline and Delamanid) and short treatment regimens with and without injectables. It is important to document the outcomes of the treatment regi…
Ivy Rukasha, Kabelo Gabriel Kaapu, Sarah M Fortune, Molebogeng Ruth Lekalakala-Mokaba
…ne (BDQ) has now become part of all standard drug-resistant regimens globally. However, emerging BDQ resistance is a growing worry, especially in areas with high rates of TB and HIV. This study aimed to compare BDQ-based regimens to non-BDQ-based treatments over a four-year perio…
Auchynka V.P.
…dy the effectiveness of treatment with delamanid-containing regimens in patients with multidrug-resistant and extensively drug-resistant tuberculosis and comorbid cardiovascular diseases, to assess the frequency, structure, and severity of adverse events in the cardiovascular sys…
Keertan Dheda, MBChB
This study aims to evaluate the impact of a new injection-free six-to-nine month treatment regimen of linezolid, bedaquiline, levofloxacin, pyrazinamide (PZA) and ethionamide/high dose isoniazid (INH) compared to the conventional empiric injection-based regimen. The secondary aim…
Nana Kiria, Zaza Avaliani, Tamar Togonidze, Lali Mikiashvili
<b>Background:</b> Short, all oral 6-month regimens of bedaquiline-pretomanid-linezolid (BPaL) were highly effective for the treatment of drug-resistant tuberculosis in clinical trials. Scarce data about the programmatic use of BPaL schemes. <b>Aim:</b> To assess the efficac…
Russell R. Kempker, Lali Mikiashvili, Yuan Zhao, David Benkeser, Ketino Barbakadze, et al.
…tients receiving bedaquiline- and delamanid-based treatment regimens for drug-resistant TB had similar characteristics and those receiving bedaquiline had better clinical outcomes. Our results provide an important first comparison of bedaquiline vs. delamanid containing regimens.…
N. Yu. Nikolenko, D.А. Kudlаy, Borisov Se, T. E. Sannikova, N. P. Doktorovа
…ients in the group with bedaquiline-containing chemotherapy regimens reached the outcome of “treatment successfully completed” (patient was cured or transfered into the III group of dispensary follow-up) compared to 51.8% in the OBR group. The use of “new” etiotropic therapy regi…
Wamaka Kaminyoge, Reuben Simfukwe, Mwiza Singini, Norman Sitali, Felix P Chilunga
…B) face major treatment challenges. Although newer all-oral regimens have transformed adult TB care, their use in younger populations has largely been extrapolated from adult studies, despite important biologic and clinical differences. Systematic and up-to-date evidence on the e…
Jason E Cummings, Lisa K Woolhiser, Vincent Guglielmi, Ashely Romano, Samantha Pauly, et al.
…acy of bedaquiline, delamanid, and linezolid (BDL) and BPaL regimens in a high-burden preclinicalmouse model. Treatment with pretomanid and delamanid monotherapies and dual therapy with bedaquiline-linezolid was also conducted for comparison. Mice were treated for 2, 4, or 8 week…
Li S-Y, Tyagi S, Soni H, Betoudji F, Converse PJ, et al.
…stance necessitate efforts to develop new short-course oral regimens. We recently found that the addition of GSK2556286 increases the bactericidal and sterilizing activity of BPa-containing regimens in a well-established BALB/c mouse model of tuberculosis. Here, we used this mode…
Yang Li, Yilin Zhang, Lingyun Song, Cui Cai, Yuanyuan Chen, et al.
… treatment options and significant disease burden. Existing regimens have shown high success rates but are often inaccessible globally, necessitating alternative options. **METHODS:** This study was an open-label, multicenter, single-arm study conducted in China to evaluate the …
Riccardi N, Alagna R, Saderi L, Ferrarese M, Castellotti P, et al.
… to retrospectively compare MDR-TB and pre-XDR-TB treatment regimens and outcomes in two large TB reference centres in Italy from January 2000 to January 2015. Methods A retrospective, multicentre study was conducted at the Regional TB Reference Centre Villa Marelli Institute (Mi…
Mpobela Agnarson A, Williams A, Kambili C, Mattson G, Metz L
Background : Bedaquiline-containing regimens have demonstrated improved outcomes over injectable-containing regimens in the long-term treatment of multidrug-resistant tuberculosis (MDR-TB). Recently, the World Health Organization (WHO) recommended replacing injectables in the sta…
Tanneau L, Karlsson MO, Svensson EM
…tion, and to explore the performances of alternative dosing regimens through simulations. Methods The bedaquiline exposure-response relationship was validated using time-to-positivity data from 233 newly diagnosed or treatment-experienced patients with drug-resistant tuberculosis…
Ignatius EH, Swindells S
…mong people with HIV remain unacceptably high. Short-course regimens for TB, incorporating both novel and established drugs, offer the potential to enhance adherence and completion rates, thereby reducing the global TB burden. This review will outline short-course regimens for TB…
Л. В. Панова, E. S. Ovsyankinа, E. A. Krushinskaya, A. Yu. Khiteva, О. А. Пискунова
…evaluate the efficacy and safety of short course chemotherapy regimens for multiple/extensive drug resistant tuberculosis of the respiratory system (MDR/XDR) in older children and adolescents. Subjects and Methods. A cohort prospective controlled study (2017 to 2019) included 23 pa…
Valentina Aksenova, Н. И. Клевно, А. И. Казаков, D.А. Kudlаy, А. Д. Пахлавонова, et al.
Introduction. The treatment of children with multidrug-resistant and extensively drug-resistant tuberculosis (MDR / XDR-TB) is a difficult task due to many factors: the duration of treatment, the lack of drugs with children’s dosages, age restrictions (according to the drug instr…
N.А. Lytvynenko, Maryna Pogrebna, L. M. Protsyk, Yu.О. Senko, В. В. Давыденко, et al.
New 6-months regimen based on bedaquiline, pretomanid and linesolid (BPaL), evaluated in TB-PRACTECAL clinical trial, is one of modern treatments for extensively drug resistant tuberculosis. Patients on BPaL should be carefully observed for side effects, especially liver toxicity…
Oki Nugraha Putra, Ana Khusnul Faizah, Nani Wijayanti Dyah Nurrahman
…amanid. Unsuccessful treatment ranged from 7.8% to 36.6% in regimens containing bedaquiline, delamanid, or both at six months or after treatment completion. Low rates of treatment failure and loss to follow-up were reported in the included studies. Elderly, being underweight (BMI…
Vasavi Gedela, Banerji Neerugatti, Chiranjeevi Uday Kumar, Hari Jagannadha Rao
Background: MDR-TB is defined as a TB patient whose biological specimen is resistant to isoniazid and rifampicin with or without resistant to other first line drugs, based on results from quality assured laboratory. The main aim of this study was to study the treatment outcomes o…
Tushar Garg
…2035. The treatment of MDR- and XDR-TB consists of 4–6 drug regimens for durations of 1–2 years. In this open label, single-group study in 3 sites, the safety and efficacy of a 3-drug regimen, including bedaquiline, linezolid, and pretomanid (BPaL), was assessed for treatment of …
Priyanka Thota Nikhil Reddy Ravula
Drug-resistant tuberculosis (TB) poses a significant global health challenge, demanding effective and innovative treatment strategies. The Bedaquiline, Pretomanid, and Linezolid (BPaL) regimen has emerged as a promising approach in the fight against multidrug-resistant and extens…
Abhijeet Yadav
…g success rates, necessitating exploration into alternative regimens. Understanding the outcomes of these diverse treatment approaches is crucial for optimizing patient care and combating the spread of resistant strains. Aims & Objectives: This study aims to investigate the o…
Mijala Bajracharya, Sanjeev Singh, Sabin Shrestha, Usha Giri
Introduction: Multi drug resistance is a serious threat for high prevalence countries and may have some effect on low prevalence countries and it is defined as resistance to at least isoniazid and rifampicin. Drug resistance tuberculosis results from in sufficient chemotherapy an…