Showing 51–75 of 200 documents
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Assefa DG, Bedru A, Zeleke ED, Negash SE, Debela DT, et al.
Background Treatment of latent tuberculosis infection (LTBI) is effective in preventing progression to TB disease. This study aimed to synthesize available evidence on the efficacy, adherence, and safety of LTBI treatment in order to assist policymakers to design appropriate nati…
Zareen Zaka, Thomas Satre
University of Minnesota, St. Cloud Hospital FMR, St. Cloud, MN The authors declare no conflicts of interest.
Pei-Chun Chan, Pin-Hui Lee, Min-Ju Lu, You-Chieh Huang, Teng-Yi Feng, et al.
<b>Our experience has shown that with proper support and medical care under programmatic conditions, it is feasible to achieve a high completion rate of 3HP even among the elderly</b>http://ow.ly/o3ED30nQfRx
Erick Manuel Delgado Moya, Diego Samuel Rodrigues
<p>In this paper, we proposed a mathematical model for the study of tuberculosis treatment with latent treatment, taking into account the 3HP and 1HP. The model is constructed using a fractional order derivative in the Caputo sense to take advantage of the memory effect. Th…
Zeng J, Zhu D, Zhang H, Lin T, Song T
Objectives To evaluate the effectiveness and safety of Interferon-gamma release Assay (IGRA)-based isoniazid (INH) prophylaxis strategy to prevent tuberculosis (TB) infection in kidney transplantation (KT) with a risk of TB occurrence. Methods Adult KT recipients (KTRs) between J…
Esther Alice Nalugga, Joseph Musaazi, Yukari C Manabe, Nelson Kalema, Barbara Castelnuovo, et al.
**BACKGROUND:** Isoniazid preventive therapy (IPT) is recommended for the treatment of latent tuberculosis (TB) infection and is beneficial for persons living with HIV (PLHIV) even after initiation of antiretroviral therapy (ART). After the roll out of dolutegravir (DTG)-based AR…
Hedges KNC, Borisov AS, Saukkonen JJ, Scott NA, Hecker EJ, et al.
Background/aims Efficient recruitment of eligible participants, optimizing time and sample size, is a crucial component in conducting a successful clinical trial. Inefficient participant recruitment can impede study progress, consume staff time and resources, and limit quality an…
Aleksei O. Barnaulov, Irina A. Rasmagina, Marina N. Kondakova, Vitaliy V. Khabirov, Elena B. Lelekova
Background. Biological agents, especially anti-tumor necrosis factor blocking agents, frequently are used to treat autoimmune inflammatory rheumatic diseases. Due to their negative impact on immune system and high risk of reactivation of latent tuberculosis infection all the pati…
Freundeskreis Für Internationale Tuberkulosehilfe e.V
… to active disease. The long treatment of TB infection with regimens lasting from three to nine months is a significant barrier to treatment completion in individuals with a confirmed diagnosis of TB infection. Adapting a shorter regimen than the current regimens could lead to a …
Jann-Yuan Wang, MD. PhD.
…lease assay (IGRA). For preventive therapy, the recommended regimens include daily isoniazid for 9 months and daily rifampicin for 4 months. By incorporating long-acting rifapentine, a new regimen combining weekly rifapentine and high-dose isoniazid for a total of 12 doses has be…
Jorge Cardenas, Maria E. Campos-Bonaguro, Jacques Simkins
…ty rates in this population. In addition, current treatment regimens are associated with variable degrees of hepatotoxicity [isoniazid (INH) and rifamycins] and drug-drug interactions (DDIs) with immunosuppressants that hamper graft function and may precipitate organ rejection (r…
Menzies D, Adjobimey M, Ruslami R, Trajman A, Sow O, et al.
Background A 9-month regimen of isoniazid can prevent active tuberculosis in persons with latent tuberculosis infection. However, the regimen has been associated with poor adherence rates and with toxic effects. Methods In an open-label trial conducted in nine countries, we rando…
Tseng SY, Huang YS, Chang TE, Perng CL, Huang YH
…atotoxicity, efficacy and completion rate between these two regimens. Methods We searched all literature in the major medical databases using the subject search terms "isoniazid" and "rifapentine", and performed a systemic review and meta-analysis. Results A total of 14 studies w…
Kim Y, Bae KS, Choi UY, Han SB, Kim JH
Background The treatment of pediatric patients with latent tuberculosis infection (LTBI) is a crucial TB control strategy. LTBI is not a reportable communicable disease, and data regarding LTBI treatment in pediatric patients in Korea are scarce. This study aimed to investigate t…
Njie GJ, Morris SB, Woodruff RY, Moro RN, Vernon AA, et al.
…ered by directly observed therapy. However, longer-duration regimens remain the most widely prescribed latent tuberculosis infection treatments. Limitation on adoption of 3-month isoniazid-rifapentine in the U.S. might be because of patients' preference for self-administered ther…
Deborah Delaguila
…mitant medications. Homeless participants in both treatment regimens were more likely to be of African descent (p Conclusion: Homeless persons present many challenges in treatment for any disease, particularly one that requires lengthy treatment and follow-up such as tuberculosis…
Dick Menzies
Rationale: Shorter regimens of high dose daily rifampin may be safe, and as effective as the standard rifampin regimen when taken for 4 months to treat latent TB (LTBI). However, there is insufficient evidence on the optimal dose of rifampin that has similar efficacy as the stan…
Srivastava S, Cirrincione KN, Deshpande D, Gumbo T
Background: Mycobacterium tuberculosis [ Mtb ] could be present in different metabolic population in the lung lesions, and nonreplicating persisters [NRP], associated with latent tuberculosis [TB], are the most difficult to kill. Objective: Test the combination of tedizolid, moxi…
Melnychuk L, Perlman-Arrow S, Lisboa Bastos M, Menzies D
…entially serious adverse events (AE) is a limitation of TPT regimens. We conducted a systemic review and meta-analysis to estimate the incidence of AE and hepatotoxicity with various TPT regimens to help inform clinical decision making. Methods We searched MEDLINE, Cochrane, Heal…
Lifan Zhang, Yujie He, Wenwen Wang, Lijun Wu, Xiaoxia Zuo, et al.
**BACKGROUND:** Patients with rheumatic diseases are at high risk for latent tuberculosis infection (LTBI) reactivation. We aimed to evaluate whether a modified 3-month regimen (3HP-PUMCH) was non-inferior to the standard 9-month isoniazid regimen (9H) for tuberculosis preventive…
Kim HW, Kim JS
…een 18 and 65 years, should undergo LTBI treatment. Various regimens for LTBI treatment were recommended in NICE, World Health Organization (WHO), and Centers for Disease Control and Prevention guidelines, and superiority of one recommended regimen over another was not yet establ…
Soumya Chatterjee, MD
Center for Disease Control (CDC) data reveal that after years of sustained decrease, the incidence of active tuberculosis (TB) disease in the US has plateaued. Most of the cases occur when Mycobacterium tuberculosis (Mtb) reactivates replication in people who have latent tubercul…
Shu‐Yung Lin, Ping-Huai Wang, Jia‐Yih Feng, Chin‐Chung Shu
…I) had not been studied yet. <b>Aim:</b> To compare the two regimens – twelve-dose weekly rifapentine plus isoniazid (3HP) and nine-month daily isoniazid (9H) for LTBI among patients under maintenance dialysis, with emphasis on completion rate and adverse drug reactions (ADR). <b…
Jonas DE, Riley S, Lee L, Coffey C, Wang SH, et al.
…ssays (IGRAs) or (2) treatment of LTBI with pharmacotherapy regimens that are currently recommended by the Centers for Disease Control and Prevention. We excluded studies of close contacts of persons with active tuberculosis (TB) because testing and treatment of such populations …
Yi Wang, Yayan Niu, Jianping Zhang, Zhijian Ye, Meiying Wu, et al.
…9 cases). Depending on the different prophylactic treatment regimens, the completion rate and incidence of adverse drug reactions were compared between the different treatment groups. Results Close contact history with a pulmonary tuberculosis patient and malnutrition were the ma…