Showing 51–75 of 200 documents
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Abstract BACKGROUND Tuberculosis (TB) is a rare but potentially devastating infection among Canadian children. Accurate diagnosis and initiation of treatment are limited in part by the fact that it takes 2–6 weeks for culture results to be confirmed. Xpert MTB/RIF (Xpert) is a ra…
Enane LA, Christenson JC
Infants, children and adolescents are at risk of life-threatening, antimicrobial-resistant infections. Global burdens of drug-resistant TB, HIV and gram-negative pathogens have a particular impact on paediatric age groups, necessitating a paediatric-focused agenda to address emer…
Ali AM, Radtke KK, Hesseling AC, Winckler J, Schaaf HS, et al.
Rifampicin-resistant tuberculosis (RR-TB) involves treatment with many drugs that can prolong the QT interval; this risk may increase when multiple QT-prolonging drugs are used together. We assessed QT interval prolongation in children with RR-TB receiving one or more QT-prolongi…
Ashish William, Yogita Rai, Ravinder Kaur
Objectives: India has the largest burden of MDR-TB worldwide, with an annual incidence of 1,30 000 patients. Multidrug-resistant tuberculosis (MDR-TB) carries a poor prognosis, a high mortality rate, and treatment success rates as low as 65%. The mortality in India is estimated t…
Zahra Hasan, Sadia Shakoor, Rumina Hasan
…ion, Geneva, Switzerland2021Google Scholar], however, 4% of pediatric cases were not notified and these occurred mainly in LMICs. Health system factors such as lack of access and marginalization account for missed cases, especially in 2020. Case notifications show a shortfall in …
Dong-Mei Wang, Qi An, Qing Yang, Yi Liao
…To describe the demographic and clinical characteristics of pediatric tuberculosis (TB) inpatients diagnosed with resistance to any anti-tuberculosis drug [drug-resistant tuberculosis (DR-TB)] in southwest China. **METHODS:** Patients aged ≤14 years with clinically…
Ana Alvarez, Mobeen H. Rathore
… recommendations in the areas of diagnosis and treatment of pediatric tuberculosis in the past few years. Due to the low incidence of tuberculosis in the United States, many primary care providers may not be familiar with these new recommendations.After completing this article, r…
PrasantaKumar Das, SomtirthaB Ganguly, Bodhisatya Mandal
…of an effective control. India accounts for 6% incidence of pediatric TB cases in a population that has 40% as estimated latent TB cases. Pediatric samples were considered as the key population in the study. TB remains the most common cause of childhood meningitis in high burden …
Jenkins HE, Yuen CM
…ular, there have been two efforts to estimate the burden of pediatric multidrug-resistant TB (MDR-TB). Methods We review current estimates of the global incidence of pediatric MDR-TB disease. We then combine pediatric MDR-TB treatment data from the World Health Organization and r…
Tucker EW, Dooley KE
…ns have been extrapolated from adults to children. However, pediatric disease merits different treatment strategies to avoid under- or over-treatment. While animal models have been pivotal in identifying effective regimens for adult disease, pediatric TB is heterogeneous and cann…
Yiheyis Genetu, Bethelhem Belay, Workeabeba Abebe
… DNA and resistance to rifampicin (MTB/RIF) test can detect pediatric tuberculosis and its multidrug-resistant form with very high sensitivity and specificity, but limited data exists on its use in our country. We aimed to evaluate the effectiveness of the GeneXpert assay in comp…
Arnab Kumar Samanta, K. Pál, Priyanka Saha, Retina Paul
Background: Febrile illness in pediatric populations often poses a diagnostic challenge due to overlapping clinical features across various etiologies. While respiratory infections are common, urinary tract infections (UTIs) are significant contributors to morbidity, frequently c…
Christoph Lange, Professor
…iagnostic techniques that are both accurate and feasible in pediatric settings. In recent years, researchers have explored innovative approaches, including the utilization of alternative sample types such as mask samples, urine, or stool, for TB diagnosis in children. These alte…
International Centre for Diarrhoeal Disease Research, Bangladesh
…ms to fill critical knowledge gaps, particularly concerning pediatric post-TB health outcomes, by evaluating a cohort of individuals who have completed TB treatment and comparing them with non-TB-exposed counterparts. The study will also assess quality of life, growth in children…
Anupama Mauskar, Amrit Gopan
…th highest burden of TB. There is paucity of data as far as Pediatric TB is concern. TB in children directly reflects intensity of on-going transmission of TB in a given community. This study was done including indoor cases of Pediatric pulmonary TB in a medical college hospital,…
Gülşen Akkoç, Seyhan Yılmaz, Sevgi Aslan Tuncay, Aylin Dizi Işık, Pınar Canizci Erdemli, et al.
…t.u.berculosis infection (LTBI) and active TB disease among pediatric household contacts of adults with pulmonary multidrug-resistant (MDR) or drug-susceptible (DS) TB and identify risk factors associated with TB infection.Methods: This retrospective study included children (0–18…
Roya-Pabón C, Restrepo A, Morales O, Arango C, Maya MA, et al.
Tuberculosis (TB) in the pediatric population is a major challenge. Our objective was to describe the clinical and microbiological characteristics, radiological patterns, and treatment outcomes of children and adolescents (from 1 month to 17 years) with community-acquired pneumon…
О. М. Raznatovska, A. S. Moskaliuk, Тетяна Анатоліївна Грекова, L. I. Chernyshоva, O. O. Pushnova, et al.
…th Organization (WHO) reports an unknown contact history of pediatric tuberculosis (TB), especially in children younger than 5 years old. Tracing pediatric household contacts of patients with multidrug-resistant TB (MDR-TB) is considered to be a highly effective intervention for …
Bjugård Nyberg H, Draper HR, Garcia-Prats AJ, Thee S, Bekker A, et al.
…rrent doses are extrapolated from weight-based adult doses. Pediatric doses based on more robust evidence are expected to improve antituberculosis treatment, especially in small children. In this analysis, ethionamide concentrations in children from 2 observational clinical studi…
Padmapriyadarsini C, Das M, Burugina Nagaraja S, Rajendran M, Kirubakaran R, et al.
…eventive therapy in reducing the incidence of TB disease in pediatric contacts of MDR-TB patients. Methods We conducted a literature search for randomized control trials, cohort studies, and case reports of chemoprophylaxis for pediatric contacts of MDR-TB patients in PubMed, EMB…
Bossù G, Autore G, Bernardi L, Buonsenso D, Migliori GB, et al.
…experience on treatment of multi-drug resistant (MDR)-TB in pediatrics. Areas covered The aim of this review is to analyze and summarize therapeutic options available for children experiencing MDR-TB. We also focused on management of MDR-TB prophylaxis. Expert opinion The therape…
Garcia-Prats AJ, Frias M, van der Laan L, De Leon A, Gler MT, et al.
…s been approved by the European Commission for treatment of pediatric MDR-TB patients at least 10 kg in weight, making the drug no longer limited to adults. A 10-day phase I age deescalation study was conducted, followed by a 6-month phase II extension study, to assess the pharma…
Amyn A. Malik, Mercedes C. Becerra, Hamidah Hussain
…t tuberculosis: a practical guide. The Sentinel Project for Pediatric Drug-Resistant Tuberculosis, Boston, USA2018Google Scholar]. TB preventive treatment is both effective and cost-effective in protecting these individuals from avoidable illness and death [[4]Marks S.M. Mase S.R…
Abhay Thakur
Pediatric TB is particularly challenging considered the long duration of treatment, compliance to therapy this involves and emergence of multidrug resistant (MDR)-TB as well as morbidity related to MDR-TB in pediatric age group. They betray the acute necessity of new therapeutic …
Gaensbauer JT, Dash N, Verma S, Hall DJ, Adler-Shohet FC, et al.
Pediatric multidrug-resistant tuberculosis (MDR-TB) remains a significant global problem, and there are numerous barriers preventing children with MDR-TB from being identified, confirmed with microbiologic tests, and treated with a safe, practical, and effective regimen. However,…