Showing 51–75 of 200 documents
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Pole I, Trofimova J, Norvaisa I, Supply P, Skenders G, et al.
Although the number of new tuberculosis (TB) cases registered per year has decreased by 3-fold between 2001 and 2017 in Latvia, the TB incidence and rates of multidrug resistant TB in this Baltic country remain substantially higher than in most other European countries. Molecular…
Nigussie Assefa Kassaw, Jemal Haidar, Dawit Getachew Assefa, Daniel Fiseha, Dereje Habte, et al.
Ethiopia is among the thirty-high tuberculosis (TB) burden countries with multidrug resistant tuberculosis (MDR-TB) and Tuberculosis/Human Immunodeficiency Virus (TB/HIV). Given the public health importance of the problem, it is apparent that probing the work done in this regard …
Lalor MK, Casali N, Walker TM, Anderson LF, Davidson JA, et al.
We used whole-genome sequencing (WGS) to delineate transmission networks and investigate the benefits of WGS during cluster investigation.We included clustered cases of multidrug-resistant (MDR) tuberculosis (TB)/extensively drug-resistant (XDR) TB linked by mycobacterial intersp…
Auld SC, Shah NS, Mathema B, Brown TS, Ismail N, et al.
Despite evidence that transmission is driving an extensively drug-resistant TB (XDR-TB) epidemic, our understanding of where and between whom transmission occurs is limited. We sought to determine whether there was genomic evidence of transmission between individuals without an e…
Liu Z, Li X, Xiong H, Zhou Q, Yi H, et al.
…ited. This study aimed to investigate molecular and spatial epidemiology of TB in two mountainous, rural counties of Zhejiang Province, China, from 2015 to 2021, to elucidate the recent transmission and drug-resistance profiles. The predominant Lineage 2 (L2) Beijing family accou…
Sun J, Fan L, Zhao Y, Wu H, Li R, et al.
…children seriously threatens TB control. Information on the epidemiology and characteristics of DR-TB in children in China is limited. We studied data in Shenyang Tenth People's Hospital to understand the DR-TB epidemiology in children in Shenyang. Design or methods We retrospect…
Thwaites CL, Lundeg G, Dondorp AM, Adhikari NKJ, Nakibuuka J, et al.
…ed. Choice of combination therapy should be guided by local epidemiology and known effective combinations. Antimicrobial therapy should be de-escalated whenever possible. It is recognized that without microbiological information, de-escalation is difficult. The use of biomarkers …
Santosa A, Juniarti N, Pahria T, Susanti RD
Background Tuberculosis (TB) treatment non-compliance remains a significant global public health issue, undermining disease control efforts and leading to adverse clinical and epidemiological outcomes. While considerable research has explored this issue, gaps remain in understand…
Macedo R, Pinto M, Borges V, Nunes A, Oliveira O, et al.
Whole-genome sequencing (WGS) offers unprecedented resolution for tracking Mycobacterium tuberculosis transmission and antibiotic-resistance spread. Still, the establishment of standardized WGS-based pipelines and the definition of epidemiological clusters based on genetic relate…
Xichao Ou, Xiangchen Li, Shaojun Pei, Bing Zhao, Liping Feng, et al.
…es in 2022. This study provides insights into the molecular epidemiology and transmission dynamics of TB in HL. Our results underscore the ongoing problem of TB transmission in rural settings, indicating the need for targeted interventions. These findings are vital for informing …
Dong Jin Joo
We argue in favor of a concerted and coordinated response to stop tuberculosis (TB) by monitoring global TB spread, drug-resistance surveillance and populations at risk using available molecular and web tools to identify circulating clones of Mycobacterium tuberculosis complex (M…
Luísa Heinzen Cescon, Ana Júlia Probst Nichellatti
Drug-resistant tuberculosis represents one of the main challenges for disease control in Brazil. Cases of multidrug-resistant tuberculosis (TB-MDR) and extensively drug-resistant tuberculosis (TB-XDR) increase treatment duration, costs, and the risk of unfavorable outcomes. This …
He W, Tan Y, Liu C, Wang Y, He P, et al.
…dy aimed to provide us with deep insight into the molecular epidemiology of RR-TB isolates circulating in Hunan province by combining phenotypic drug susceptibility testing and whole-genome sequencing. To our knowledge, this is the first study to use whole-genome sequencing data …
Suphanat Wongsanuphat, Charuttaporn Jitpeera, Orathai Suwanchairob, Wannisa Theprongthong, Patcharin Tantiworrawit, et al.
On 31 May 2019, the Division of Epidemiology (DoE) was notified of a confirmed extensively drug-resistant tuberculosis (XDR-TB) case in Bangkok. The DoE and local teams conducted a joint investigation to describe the epidemiological characteristics of the case, identify possible …
N.A. Pavluchenkova, A.V. Mikheeva, E. A. Sakharitova
The spread of multidrug-resistant and extensively drug-resistant tuberculosis (MDR and XDR) requires the search and implementation of not only new diagnostic methods, but also innovations in the treatment of the disease. Aim. The assessment of current treatment options for multid…
Iglesias MJ, Ibarz D, Cebollada A, Comín J, Jiménez MS, et al.
Molecular epidemiology of circulating clinical isolates is crucial to improve prevention strategies. The Spanish Working Group on multidrug resistant tuberculosis (MDR-TB) is a network that monitors the MDR-TB isolates in Spain since 1998. The aim of this study was to present the…
Chae H, Shin SJ
Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), remains a serious global health problem in the 21 st century because of its high mortality. Mtb is an extremely successful human-adapted pathogen that displays a multifactorial ability to control the host immune respo…
Eskild Petersen, David S.C. Hui, Jean B. Nachega, Francine Ntoumi, Delia Goletti, et al.
…nostics in many LMICs impaired proper assessment of disease epidemiology, detection and response capacities [[16]Nachega JB Nsanzimana S Rawat A Wilson LA Rosenthal PJ Siedner MJ et al.Advancing detection and response capacities for emerging and re-emerging pathogens in Africa.La…
Kozińska M, Bogucka K, Kędziora K, Szpak-Szpakowska J, Pędzierska-Olizarowicz W, et al.
Drug-resistant TB (DR-TB) in children is a special epidemiological, clinical, and diagnostic problem, and its global incidence remains unknown. DR-TB in children is usually of a primary nature and is most often transmitted to the child from a household contact, so these cases ref…
Guo Y, Li J, Lin L
Background Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis . Drug-resistant tuberculosis (DRTB) includes multidrug-resistant tuberculosis without extensive drug resistance (MDRTB) and extensively drug-resistant tuberculosis (EDRTB). Recently, with …
Mareli Claassens, PhD
Poor case management, pharmacokinetic variability and on-going transmission have fostered the drug-resistant tuberculosis (DR-TB) epidemic leading to a global estimated number of \>500,000 new multidrug resistant (MDR) TB cases per year, of which roughly 10% are extensively drug …
Eimer J, Patimeteeporn C, Jensenius M, Gkrania-Klotsas E, Duvignaud A, et al.
…e gaps remain about migration- and travel-associated MDR-TB epidemiology. The aim was to describe epidemiologic characteristics among international travellers and migrants with MDR-TB. Methods Clinician-determined and microbiologically confirmed MDR-TB diagnoses deemed to be rela…
Eskild Petersen, Martin Rao, Giuseppe Ippolito, Gina Gualano, Jeremiah Chakaya, et al.
…e capability and utility of the spatio-temporal approach in epidemiology characteristics and suggested that the high-risk periods and areas should be paid more attention for monitoring and early warning. A study from the State of Paraná, Brazil, from 2008 to 2015 of 944 deaths of…
В. Н. Даниленко
In assessing the threats related to the 12 most dangerous infectious diseases, the World Health Organization (WHO) considers the struggle against multidrug-resistant/extensively drug-resistant (MDR/XDR) forms of the causative agent of tuberculosis, Mycobacterium tuberculosis, as …
Liu KH, Xiao YX, Jou R
Introduction Multidrug-resistant tuberculosis (MDR-TB) remains a challenge in the TB program of Taiwan, where 0.5% of new cases and 2.1% of previously treated cases were resistant to at least rifampin (RIF) and isoniazid (INH). Since >80% of our MDR-TB are new cases, genotyping o…