Showing 51–75 of 200 documents
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Radha Gopalaswamy, Selvakumar Subbian
…sened by co-existing health conditions and the emergence of drug-resistant (DR-TB) cases. The WHO has declared TB as a global emergency and endorsed global efforts to improve diagnosis, and treatment while reducing the catastrophic cost in an EndTB strategy in 2013, with a vision…
Osugi A, Tamaru A, Yoshiyama T, Iwamoto T, Mitarai S, et al.
… of the acquisition of mutations responsible for antibiotic resistance and increased virulence was lower in the Mtb population from LTBI than active disease.IMPORTANCEControlling latent tuberculosis (TB) infection (LTBI) activation is an effective strategy for TB elimination, whe…
Ido Tzanani, Daniel Bendayan, Anat Jaffe, Zohar Mor
… To compare tuberculosis treatment outcomes and the rate of drug resistance of tuberculosis patients with or without DM. METHODS: This case-control study was conducted between 2005 and 2015 at the only tuberculosis ward in Israel. All 80 tuberculosis patients who had DM and were …
Lara Beth Gadkowski, Connie A. Haley
…rium tuberculosis</italic> DNA and mutations that confer TB drug resistance. Treatment of drug-susceptible TB consists of isoniazid, rifampin, pyrazinamide, and ethambutol for 2 months, followed by isoniazid and rifampin for 4 months. Monitoring for drug interactions, toxicity, i…
Maria Norrby
…olonged treatment is necessary and can cause severe adverse drug reactions. A well-functioning TB program is essential to interrupt the transmission of infection in the community. The increasing global problem of resistant TB-strains necessitates development of a new tuberculosis…
Z Wang, W J Wang, X Y Ding, P Lu, Limei Zhu, et al.
… to reduce the risk for TB. Contacts of patients with multi-drug and rifampicin-resistant TB (MDR/RR-TB) are at high risk for the infection with drug-resistant pathogen, however, no unified prophylactic therapy regimen has been recommended for LTBI due to exposure to MDR/RR-TB pa…
Alexandre Giraud-Gatineau, Juan Manuel Coya, Alexandra Maure, Anne Biton, M. Thomson, et al.
…and M. tuberculosis-infected macrophages incubated with the drug, with an over-representation of lysosome-associated genes. BDQ treatment triggered a variety of antimicrobial defense mechanisms, including phagosome-lysosome fusion, and autophagy. These effects were associated wit…
Javier E. Irazoqui, Jeffery S. Cox
…and M. tuberculosis-infected macrophages incubated with the drug, with an over-representation of lysosome-associated genes. BDQ treatment triggered a variety of antimicrobial defense mechanisms, including phagosome-lysosome fusion, and autophagy. These effects were associated wit…
Seyedeh Mahnaz Karimi
…mmunodeficiency virus (HIV) epidemics, and the emergence of drug resistance. In spite of various modern treatments, some reasons like total cost, efficacy, safety, and drug resistance have caused a global willingness towards natural remedies. Therefore, the aim of this chapter is…
Yew WW, Chang KC, Chan DP, Zhang Y
To complement the development of new or repurposed drugs for improving the treatment outcomes of drug-susceptible and drug-resistant tuberculosis, current insight also focuses on the use of host-directed therapy. Metformin, a drug often used in the management of type 2 diabetes m…
Anna Starshinova, Ekaterina Belyaeva, Olga Irtyuga, Giunai Sefiyeva, Lubov Mitrofanova, et al.
…ostpartum period, for the benefit of both mother and child. Drug-drug interactions play a significant role in tuberculosis management, both among anti-tuberculosis agents and with medications for comorbid conditions. Current knowledge of the pharmacokinetics and pharmacodynamics …
Xue Wu, Xu Zhang, Wei Xia, Yu Zhang, Kaifang Huang, et al.
Drug-resistant Mycobacterium tuberculosis remains a major challenge to effective tuberculosis (TB) control. Cytochrome bd oxidase (Cyt-bd), a critical terminal oxidase within the electron transport chain of M. tuberculosis, maintains bacterial survival under respiratory stress bu…
Yong Li, Linlin Song, Ying Zhang, Zhenzhou Feng, Feng Sun, et al.
…cess have been rarely studied, especially in the context of drug-resistant tuberculosis treatment. Methods: This study was a sub-study embedded within the TB-TRUST study (NCT03867136) and TB-TRUST plus study (NCT04717908). Participants aged 18-70 years old with pulmonary rifampic…
Yu. I. Feshchenko, Olga Bilogortseva, Ярослава Ігорівна Доценко, Iryna Shekhter, Oksana Sivachenko, et al.
…antly, from 13.6% to 23.0%, and the number of patients with drug-resistant (DR) TB (in children by 11.0% in 2020). The volume of professional examination of children for TB decreased significantly, which led to an increase in the structure of the disease of severe forms requiring…
Digambar Behera
…te on its protective role. At present, there was no data on drug-drug interactions.[21] Another study data from 49 consecutive cases in 8 countries and 20 hospitalized patients with TB and COVID-19 showed that 8 out of 69 (11.6%) patients died. Most of them were young migrants. I…
Kalema N, Semeere A, Banturaki G, Kyamugabwa A, Ssozi S, et al.
…xcluding TB by symptom screening alone and feared promoting drug resistance. Although isoniazid was available, past experience of irregular supply discouraged TPT initiation. Providers pointed to insufficient TB-dedicated staff, speculated that patients discounted TB risk, and wo…
Vishrutha Poojari, K.S. Shah, Ira Shah
…for another month with no improvement, raising suspicion of drug-resistant TB. High-resolution computed tomography of the chest in October 2018 to look for mediastinal nodes, showed collapse/consolidation of the anterior segment of the left upper lobe with surrounding areas of il…
Vanaja Kumar, Vanaja Kumar, Ramasamy Balagurunathan, Mukesh Doble, Radhakrishnan Manikkam, et al.
… AIDS-associated mortality. So there is a dire need for new drugs to combat such ailments that have a synergistic interaction.This has led us to study a novel antibiotic purified from a marine Streptomyces sp isolated from the coral reef ecosystem of South Indian coast. Streptomy…
Fargher J, Reuter A, Furin J
…ion. Recent findings Treatment of infection for both TB and drug-resistant TB is well tolerated and effective, and several new, shorter regimens - including rfiapenitine-based regimens of 1 month and 12 weeks duration - have been shown to be effective. Not all persons infected wi…
Sarvesh Kumar Singh, Divya Yadav, Anil K. Saksena, Rahul Kumar, Preeti Mishra, et al.
…t TB infection. A latent or active TB infection also can be drug-resistant, that means sure medications don’t work against the bacterium. Signs of active TB sickness include: A cough that lasts quite three weeks, chest pain, forcing out blood, feeling tired all the time, night sw…
Ayushi Saini, Aishik Sil, Satyajit Beura, Amit Kumar Das
…e to its survival under host-induced stress and the rise of drug-resistant strains. One critical factor contributing to this resilience is its ability to efficiently repair DNA damage. To survive double-stranded DNA breaks, Mtb utilizes two pathways: homologous recombination (HR)…
Kaushik A, Peshrana A, Barapatre R, Pansheriya S, Kaushal RS
…2022. Combating this disease requires ongoing efforts in TB drug discovery and the development of new treatment regimens. Identifying novel drug targets and inhibitory molecules is crucial in the fight against latent TB, particularly due to the rising issue of M. tb drug resistan…
Kiran D, Basaraba RJ
…iers, including but not limited to the development of multi-drug resistance, lack of diagnostic assays that detect patients with latent TB, an effective vaccine that prevents Mtb infection, and infectious and non-infectious comorbidities that complicate active TB, continue to hin…
Negi A, Sharma R
…lts in the disease reactivation, patient non compliance and drug resistance. The presently available drug regimen for TB largely targets the active bacilli and thus remains inadequate against the dormant or persistent subpopulation of Mtb that results in latent TB affecting a qua…
Anita Uka, Frédéric Méchaï, Daniela Maria Cirillo, Lorenzo Guglielmetti, Yousra Kherabi, et al.
… acid amplification test results in 88% of cases. Molecular drug-resistance testing on initial samples was commonly requested, most frequently for rifampicin resistance alone (47%) or combined rifampicin and isoniazid resistance (41%). Treatment practices for presumed drug-suscep…