Showing 51–75 of 200 documents
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Hauptmann M, Kalsdorf B, Akoh-Arrey JE, Lange C, Schaible UE
… in relationship to the level of Mycobacterium tuberculosis drug response. Methods Stool, sputum, and oral swab samples were analysed from participants with treatment-naïve TB and participants treated for drug-susceptible TB (DS-TB), drug-resistant TB without injectable drugs (DR…
Cicik Alfiniyah, Windarto Windarto, Nadiar Almahira Permatasari, Muhammad Farman, Nashrul Millah, et al.
…osis). It manifests in two primary forms based on bacterial drug sensitivity: drug-sensitive TB (DS-TB) and drug-resistant TB (DR-TB). DS-TB remains susceptible to medication, whereas DR-TB has developed resistance. This study explores a mathematical model explaining the spread o…
John Kauffman, Jake Cuevas, Janaya Feiner, Margaret Metzger, Gauri Shetye, et al.
…s an urgent need to develop new anti-tuberculosis (anti-TB) drugs to tackle drug-resistant strains of Mycobacterium tuberculosis (M.tb). Whereas antimicrobial peptides (AMPs) have received attention because of their antibacterial properties, oligo-N-substituted glycines (peptoids…
Debdeep Mitra, P. Sanyal, Divya Kamboj, Rakesh Kumar Deepak, Sayan Chakraborty, et al.
…re, we checked the status of host immune response among the drug resistant (DR) and Drug Sensitive (DS) tuberculosis (TB) patients. Additionally, in a phase I/ II clinical trial, we investigated impact of in vivo inhibition of PD-1 pathway on rescuing effector T cell function in …
Wang T, Yang Q, Gao Y, Zhang R, Zhou C, et al.
…mputed tomography (CT) manifestations of rifampicin primary drug-resistant pulmonary tuberculosis in Liangshan Yi Autonomous Prefecture. Patients and methods A total of 100 inpatients with confirmed primary rifampicin-resistant pulmonary tuberculosis were recruited from January 2…
Annelies Van Rie, Conor J. Meehan
…n treatment outcome, and the clinical implication of hetero-resistance in 331 patients with a single-strain Mtb infection [[1]Nimmo C. Brien K. Millard J. Grant A.D. Padayatchi N. Pym A.S. et al.Dynamics of within-host Mycobacterium tuberculosis diversity and heteroresistance dur…
Shaki Aktar
…ulosis (TB) is reducing in Bangladesh, but the emergence of drug resistant tuberculosis make the TB control effort more challenging and questionable. The present study aimed to identify the socio-demographic, behavioral and clinical risk factors for developing DR-TB.The study was…
Pelumi Daniel Adewole, Ogundipe Tosin Deborah
…d: Tuberculosis remains a leading infectious cause of death.Drug resistant tuberculosis (DR-TB) which serves as a major problem for TB control thereby serves as a major hindrance to the recent achievements.Although, there has been an increase in TB and DR-TB cases, the gaps in ca…
Deng L, Wang Q, Liu H, Jiang Y, Xu M, et al.
…, embB , gid , and cut1 ) under positive selection in multi-drug resistance (MDR) strains but not in drug-susceptible (DS) strains, in which 27 mutations were drug-resistant loci, 9 mutations were non-drug-resistant loci but were in drug-resistant genes, 2 mutations were compensa…
Susanna S van Wyk, Marriott Nliwasa, F. Lu, Chih-Chan Lan, James A. Seddon, et al.
<sec> <title>BACKGROUND</title> Finding individuals with drug-resistant tuberculosis (DR-TB) is important to control the pandemic and improve patient clinical outcomes. To our knowledge, systematic reviews assessing the effectiveness, cost-effectiveness, acceptability, and feasib…
Elmadbouly AA, Abdul-Mohymen AM, Eltrawy HH, Elhasan HAA, Althoqapy AA, et al.
Background Drug-resistant Tuberculosis (DR-TB) is a global health burden with high morbidity and mortality in developing countries including Egypt. The susceptibility to infection with DR-TB strains may be genetically determined. Several interleukin gene polymorphisms were invest…
Muhammad Dayyab F, Iliyasu G, Garba Ahmad B, Aliyu Umar I, Musa Shuaib N, et al.
Background Mycobacterium tuberculosis with resistance to first line and second line anti tuberculous drugs is a serious setback in the treatment of tuberculosis (TB). The COVID-19 pandemic constitutes a serious threat that could unwind the recent gains made thus far in the contro…
Beyene N, Sitotaw AL, Telila EG, Gebre HA, Alemu NB, et al.
Although detection of drug-susceptible TB by Anti-Persoonsmijnen Ontmijnende Product Ontwikkeling-trained African giant pouched rats has been known for more than a decade, the detection of drug-resistant TB (DR-TB) using rats has never been explored before. We present what we bel…
Perlman D, El-Sadr W
…patients. To compare toxicity, survival, and development of resistance in these two regimens. ORIGINAL: To compare the efficacy and safety of induction and continuation therapies for the treatment of pulmonary TB in HIV-infected patients who are either from areas with known high…
Benjamin Idoko Omede, Olumuyiwa James Peter, William Atokolo, Bolarinwa Bolaji, Tawakalt Abosede Ayoola
The rise of drug resistance has become a major obstacle in treating tuberculosis (TB), significantly contributing to the increasing disease burden. Therefore, it is essential to study the transmission dynamics of the disease, considering the factors that contribute to the strain’…
Yassmeen A. Hussain, Khairallah AS Mohammed, Naael Hussein Ali
…ious and deadly diseases, especially after the emergence of drug-resistant bacteria. Therefore, in this study, we developed a method to evaluate the ability of using CXCL10, CXCL9, MMP9, suPAR and the expression gene (NF-κB) and their rolesin the diagnosis and treatment of the di…
Ao Xu, Zexuan Wen, Yue Wang, Weibing Wang
…xposed-Infectious-Recovered (SEIR) model that distinguishes drug-sensitive (DS) and drug-resistant (DR) TB in the entire Chinese population was established. Goodness-of-fit tests and sensitivity analyses were used to assess model performance. Predictive analysis was performed to …
O.M. Shvets, О.С. Шевченко, Hanna Stepanenko
…D; 
 
 The study was aimed to investigate insulin resistance development in drug-susceptible newly diagnosed pulmonary tuberculosis patients. Those patients who developed insulin resistance during the 30 days of antitubercular therapy have expressed metabolic changes, t…
Van Wyk SS, Nliwasa M, Seddon JA, Hoddinott G, Viljoen L, et al.
Background Transmission of drug-resistant tuberculosis (DR-TB) is ongoing. Finding individuals with DR-TB and initiating treatment as early as possible is important to improve patient clinical outcomes and to break the chain of transmission to control the pandemic. To our knowled…
V Shukatka, L Skoklyuk, M Germanovych, A Bogdanov, T Ivanenko, et al.
…CKGROUND:** Ukraine faces intersecting epidemics of HIV and drug-resistant TB (DR-TB), with high risk of progression from TB infection to active disease. The Support TB Control Efforts in Ukraine project supported the National TB Program's efforts to operationalise World Health O…
Y L Lew, M M D Goroh, S T Yerkovich, A M H Seow, G S Rajahram, et al.
**OBJECTIVES:** Addressing drug-resistant tuberculosis (DR-TB) is a priority of the tuberculosis (TB) programme. People with DR-TB frequently have worse outcomes and require more costly and complex management, compared with those with drug-sensitive TB (DS-TB). Our study examined…
Li Liu, Jingjing Hu, Hongzhou Lu
…ed use of combination of species-specific antimycobacterial drugs. Treatment is often complicated by the intrinsic or acquired drug resistance of NTM and adverse effects of the drug combinations, and treatment failure is common.[5] Despite complex pathogenesis and difficult treat…
Ruchita A Sakaria, Bina Modi, Anjana MS, Bharti Koria, Kamlesh Vithalani
Introduction: Drug-resistant tuberculosis (DR-TB) poses a significant public health challenge in India. While treatment success in DR-TB cases remains limited, bedaquiline-based oral longer regimens have shown promising results in select studies. Objective: This study aimed to ev…
Loveday M, Gandhi NR, Khan PY, Theron G, Hlangu S, et al.
…etailed descriptions of infants born to mothers treated for drug resistant TB in pregnancy. Critical case history assessment is important to identify risks and guide clinical practice. Methods In a cohort of pregnant women with multidrug or rifampicin resistant (MDR/RR)-TB enroll…
Asmaa Ali, Liang Wu, Eman M Moazen, Sawsan Bakr Elsawy, Khadiga S. M. Salama, et al.
…a on mortality in critically ill TB patients and those with drug-resistant TB (DR-TB) is limited. This study explores hematological profiles of critically ill TB patients and those with DR-TB, investigating associations with in-hospital and short-term mortality. Methods A longitu…