Showing 51–75 of 200 documents
Sorted by hybrid relevance (keyword + semantic via RRF)
Verma AK, Yadav RN, Kumar G, Dewan RK
Objective This study aimed to analyze the trends of tuberculosis (TB) disease, drugs susceptibility patterns in geriatric TB over a period of three years (from 2010 to 2012). Materials & methods In this study, laboratory data on diagnosis of geriatric tuberculosis suspected patie…
Diriba G, Alemu A, Tola HH, Yenew B, Amare M, et al.
Background The rise of drug-resistant tuberculosis (DR-TB) has presented a substantial challenge to the national tuberculosis (TB) control program. Understanding the epidemiology of pre-extensively drug-resistant tuberculosis (pre-XDR-TB) could help clinicians to adapt MDR-TB tre…
Starshinova A, Dovgalyk I, Belyaeva E, Glushkova A, Osipov N, et al.
… continued growth of multiple- and extensive drug-resistant tuberculosis, use of the new highly effective anti-tuberculosis drugs in this patient category is of great relevance. The aim of the study was determination the efficacy of treatment in patients with multidrug- and exten…
Lynn Sosa, Lloyd N. Friedman
…he treatment facility. The usual therapy for drug-sensitive tuberculosis (TB) comprises four drugs for 2 months, dropping ethambutol once the organism is known to be sensitive to isoniazid, rifampin, and pyrazinamide; then continuing maintenance isoniazid and rifampin for 4 month…
Li H, Yuan J, Duan S, Pang Y
Tuberculosis (TB) poses a serious threat to public health worldwide since it was discovered. Until now, TB has been one of the top 10 causes of death from a single infectious disease globally. The treatment of active TB cases majorly relies on various anti-tuberculosis drugs. How…
Anita Kumari, Parveen Sharma, Rekha Bansal
…ercular drugs and may result in to extensive drug resistant tuberculosis (XDR-TB) and major challenges for successful outcome. Objective was to study treatment outcome of multi-drug resistant tuberculosis patients on second line anti-tuberculosis drugs at tertiary care hospital a…
Elena Ufimtseva, Natalya Eremeeva, Diana Vakhrusheva, Sergey Skornyakov
Tuberculosis (TB) is a significant global health threat, with one-third of the world’s population infected with causative agent <i>M. tuberculosis</i> (<i>Mtb</i>). With the increasing prevalence of multidrug and extensively drug resistant (MDR and XDR) TB, there is a need to stu…
Tuelo Mogashoa, Lucy Mupfumi, Thato Iketleng, Pinkie Melamu, Nametso Kelentse, et al.
…nt (MDR) and extensively drug-resistant (XDR) Mycobacterium tuberculosis (Mtb) strains is a serious threat to tuberculosis control in Botswana. Early detection of drug-resistant isolates is critical to ensure optimal treatment and thereby improve treatment outcomes. The objective…
DK Khadka, DS Bam, Prakash Ghimire, Amit Kumar Singh
Introduction: Tuberculosis is still one of the major public health problems in Nepal and multi drug resistant and extensively drug resistant tuberculosis (MDR /XDRTB) additionally has become serious issue. Prompt diagnosis and effective treatment of MDR/XDRTB is urgently needed. …
Dara, Masoud, Gozalov, Ogtay, World Health Organization. Regional Office for Europe
…e on the “Programmatic aspects of the implementation of new tuberculosis drugs and regimens” co-organized with the Laboratories, Diagnostics and Drug-resistance team of the Global TB Programme (GTB). The objective of the rGLC/Europe meeting and following workshop were to discuss …
Jan F, Wali S, Sadia S, Akbar MT, Akbar HS, et al.
…as been rapidly spreading in recent years. In new pulmonary tuberculosis patients, rapid spread of MDR-TB and XDR-TB challenging the effectiveness of national TB control programs especially in many low-income countries. This study was aimed to determine the resistance pattern of …
Alfonso J. Rodríguez‐Morales, Aula Abbara, Francine Ntoumi, Nathan Kapata, Peter Mwaba, et al.
World Tuberculosis (TB) Day, March 24th, 2023, will commemorate the day in 1882 when Professor Robert Koch announced his discovery of Mycobacterium tuberculosis (Mtb) when TB ravaged Europe. Over a century later, in 1993, the World Health Organization (WHO) declared TB a global h…
Mercier T, Desfontaine V, Cruchon S, Da Silva Pereira Clara JA, Briki M, et al.
Objective Anti-tuberculosis (antiTB) drugs are characterized by an important inter-interindividual pharmacokinetic variability poorly predictable from individual patients' characteristics. Therapeutic drug monitoring (TDM) may therefore be beneficial for patients with Mycobacteri…
Kashish Choudhary, Sana Tanweer, Mohd Zaid Choudhary, Sonam Grover
Tuberculosis (TB) is a health concern resulting in 10.8 million cases every year. In 2024, TB had the highest fatalities second only to COVID-19. Global TB management has become difficult due to rise of multi-drug resistant (MDR) and extensively drug-resistant (XDR) TB. Therefore…
Kunping Cui, Xiaoxiao Zhao, Wei Liu, Lang Bai
**BACKGROUND:** Multidrug-resistant tuberculosis (MDR-TB) and extensively drug-resistant tuberculosis (XDR-TB) among those aged 15-49 years pose a severe public health challenge, yet our understanding of the burden of these diseases in this age group remains limited. This study a…
Moo Sang Chong, Kyutaeg Lee
… Among the cases that showed resistance to one or more anti-tuberculosis drugs, 55 patients (33.1%) were resistant to isoniazid (INH) at the time of initial referral, and the rates for the development of resistant anti-tuberculosis drugs were ethambutol (EMB) (26.6%), rifampicin …
Mokrousov I, Vyazovaya A, Levina K, Gerasimova A, Zhuravlev V, et al.
…h control programmes influence the spread of drug-resistant tuberculosis (TB). We analysed the Mycobacterium tuberculosis population structure in Estonia, a high-priority EU country for TB control, to detect the dynamic changes and underlying factors. The study collection include…
Alberto Matteelli, Sofia Lovatti, Benedetta Rossi, Luca Rossi
Multidrug-resistant tuberculosis (MDR-TB), the deadliest form of tuberculosis (TB), has been included in the 2024 World Health Organization (WHO) priority list of antibiotic-resistant bacterial pathogens owing to its severe public health implications. Almost two billion people wo…
Iryna Makoida, Мykola Ostrovskyy, Iryna Kostitska, Оlga Molodovets, Olga Melnyk-Sheremeta, et al.
<bold>Background:</bold> The coexistence of the:tuberculosis(TB) and diabetes mellitus(DM) epidemic, however, complicates the clinical course of both conditions, which negatively impact the quality of life for patient. <bold>Purpose of the study:</bold> to analyze the impact of c…
Ohji R, Shinohara T, Ohji H, Hatakeyama N, Iwamura S, et al.
Drug-susceptibility test (DST) is important for tuberculosis care; however, there are several pitfalls with the procedure. A 70-year-old woman was diagnosed with extensively drug-resistant tuberculosis based on the result of a DST using microdilution method. Because she had no hi…
Kartik Chadhar
Tuberculosis (TB), despite extensive global efforts for elimination, continues to pose significant public health challenges, particularly in high-burden countries like India. This review explored the isolation of active (open) TB cases as a critical strategy to curb transmission …
Mancuso G, Midiri A, De Gaetano S, Ponzo E, Biondo C
…in disease management. Mismanagement of multidrug-resistant tuberculosis (MDR-TB) cases, resulting from intermittent drug use, prescription errors, and non-compliance of patients, has been identified as a critical risk factor for the development of extensively drug-resistant tube…
Sheng-Nan Tang, Xi-Ling Huang, Alena Skrahina, Qiu-Ting Zheng, Aleh Tarasau, et al.
…eful in differentiating multidrug-resistant (MDR) pulmonary tuberculosis (PTB) from drug-sensitive (DS) tuberculosis (TB) on chest computed tomography (CT). This study aims to confirm the difference in PN features between DS and MDR patients. **METHODS:** Eastern European (Belar…
Chizimu JY, Solo ES, Bwalya P, Kapalamula TF, Mwale KK, et al.
The emergence of pre-extensively drug-resistant tuberculosis (pre-XDR-TB) is a threat to TB control programs in developing countries such as Zambia. Studies in Zambia have applied molecular techniques to understand drug-resistance-associated mutations, circulating lineages and tr…
The WHO Consolidated Guidelines on Tuberculosis (TB), Module 4: Treatment - Drug-Resistant Tuberculosis Treatment 2022 update informs health care professionals in Member States on how to improve treatment and care for patients with drug-resistant TB (DR-TB). This document include…