Showing 51–75 of 200 documents
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Harirzadeh S, Kazemi MJ, Babakhani S
Introduction: Mycobacterium tuberculosis is the cause of pulmonary and extra-pulmonary tuberculosis. Latent tuberculosis is asymptomatic and the results of mycobacterial culture in this case are negative. The purpose of this study was to determine the prevalence of M. tuberculosi…
Cheng Chen, Leonardo Martínez, Biao Xu
…fth of the world population was infected with Mycobacterium tuberculosis (1)，and about 10% of the infected population will finally progress to tuberculosis (TB) disease. The risk of progressing to TB disease was significantly high in the first 2 years of infection (2). However, c…
Warria K, Nyamthimba P, Chweya A, Agaya J, Achola M, et al.
Objective To compare the prevalence of tuberculosis infection and disease in household contacts of patients with bacteriologically confirmed tuberculosis disease and contacts of non-bacteriologically confirmed disease in western Kenya. Methods We enrolled newly diagnosed index pa…
T.E. Tulkova, Pavel Chernavin, N.P. Chernavin, Yu.P. Chugaev, I.A. Cherniaev, et al.
…ation (WHO), over 23% of the human population infected with tuberculosis bacilli – M.tuberculosis. For each infected person, the likelihood of a transition from a state of latent tuberculosis infection (LTBI) to active tuberculosis remains. WHO considers testing and treatment for…
Gisele Meinerz, Cynthia Keitel da Silva, Damaris Mikaela Balin Dorsdt, Julia Bertoni Adames, Julio Pasquali Andrade, et al.
Background: Tuberculosis (TB) is an important infectious complication after kidney transplantation (KT). Latent tuberculosis infection (LTI) screening and treatment is fundamental to prevent post-transplant active disease. Methods: We described a cohort of adult KT recipients fro…
А. В. Мордык, A. N. Zolotov, Д. Г. Новиков, M. A. Romanova, N. A. Kirichenko, et al.
Publications on the role of neutrophils in tuberculosis are contradictory. The potentially versatile role of neutrophils in the pathogenesis of tuberculosis confirms that the participation of granulocytes in tuberculosis infection is important. Patients and methods. The prospecti…
Seval Özen, Hatice Uygun, Songül Çetin, Cüret Alev, Sadık Akgün, et al.
Objective: Tuberculosis is an important public health problem. Tuberculosis prevalence is high in low-income countries. It is contagious, and therefore a risk for people in public living areas. It is contagious, and therefore a risk for people in public areas. Also, people with i…
Chen H, Zhou J, Zhao X, Liu Q, Shao L, et al.
… role of soluble immune checkpoints (sICs) in Mycobacterium tuberculosis (M. tb) infection remains unknown. We assessed the levels of multiple sICs in individuals with distinct M. tb infection status, and their dynamic changes during anti-tuberculosis treatment. Methods We enroll…
Winter JR, Smith CJ, Davidson JA, Lalor MK, Delpech V, et al.
… known to increase the likelihood of reactivation of latent tuberculosis to active TB disease; however, its impact on tuberculosis infectiousness and consequent transmission is unclear, particularly in low-incidence settings. Methods National surveillance data from England, Wales…
Fabrice Uwumuremyi, Samantha Uwayezu, Sylvestre Nzayisenga, Patrick Nemeyimana, Lydivine Mpinganzima, et al.
Background: Tuberculosis is among the most widely spread and serious of all human infectious diseases. About one-third of the world's population is estimated to be infected by Mycobacterium Tuberculosis, in whom active Tuberculosis develops in nine million persons each year. This…
L. V. Slogotskaya, E. M. Bogorodskaya, L. F. Shamuratova, T. A. Sevostyanova
…the study : to compare two approaches to mass screening for tuberculosis infection in children and adolescents in Moscow. Subjects and methods . Two periods have been assessed. Period 1 (2014), when a pilot screening project was implemented in two stages: Stage 1 -all children an…
Ishikawa CS, Matsuo OM, Sarno F
… To describe the characteristics of patients diagnosed with tuberculosis and latent tuberculosis infection. Methods A retrospective study, between 2012 and 2015, with data from patients of Programa Einstein na Comunidade de Paraisópolis. To evaluate possible factors associated wi…
Cláudia Teresa Vieira de Souza, Maria de Lourdes Benamor Teixeira, Maria Isabel Fragoso da Silveira Gouvêa, Jacob Milnor, José Berilo de Lima Filho, et al.
Tuberculosis is the leading cause of death amongst adults with human immunodeficiency virus (HIV) infection. The lifetime risk of tuberculosis disease for a person with latent infection is estimated at 5-10% with most cases occurring within five years of initial infection. The Wo…
Jansen-Aaldring N, van de Berg S, van de Berg S, van den Hof S
…nd practices of patient support during treatment for active tuberculosis and for latent tuberculosis infection in European countries with a low incidence of tuberculosis and to identify potential best practices. Background Policies, practices and its' evaluations from similar set…
A. V. Lobov, E. A. Pogodina, Patrīcija Ivanova, D.А. Kudlаy, E.V. Sorokina, et al.
…tection of T-cell sensitization are widely used to diagnose tuberculosis infection. These tests belong to the interferon gamma release assay (IGRA) group and play an important role in the diagnosis of latent tuberculosis infection, as well as serving as an alternative to traditio…
Adankwah E, Nausch N, Minadzi D, Abass MK, Franken KLMC, et al.
…ase assays (IGRAs) used for diagnosis of Mycobacterium (M.) tuberculosis infection have limited sensitivity. Alternative cytokines and M. tuberculosis latency-associated antigens may improve immune-based tests. Methods Multiplex cytokine analyses was done in culture supernatants …
Rakotomanana F, Dreyfus A, Randrianarisoa MM, Raberahona M, Chevallier E, et al.
The incidence rate of tuberculosis in prisons is estimated to be 8 times greater than that in the general population in Madagascar. Our objectives were to estimate the prevalence of pulmonary tuberculosis and HIV infection among prisoners and to identify risk factors associated w…
Nirajan Niroula
The study of tuberculosis (TB) pathogenesis has benefitted from the use of animal models like mice, guinea pigs, rabbits, and non-human primates (NHPs). Except for NHP, most animal models have limitations mimicking different aspects of human TB. We propose that the domestic pig, …
Valentina Aksenova, Nadezda I. Klevno, А. И. Казаков, D.А. Kudlаy, T. A. Sevostyanova, et al.
…ologic drugs, GEBD) is associated with a high risk of local tuberculosis (TB) development. Objective. The aim of the study was to examine efficacy of tuberculosis services in children with high risk of developing tuberculosis associated with immunosuppressive therapy. Methods . T…
Joshua Rosenheim, Markos Abebe, Mulugeta Belay, Begna Tulu, Dawit Tayachew, et al.
…eviously reported detection of genomic DNA of Mycobacterium tuberculosis (Mtb) in peripheral blood mononuclear cells (PBMC) of asymptomatic adults with recent household exposure to an index case of infectious pulmonary tuberculosis (TB). It is not known whether this phenomenon in…
Chu AL, Lecca LW, Calderón RI, Contreras CC, Yataco RM, et al.
…hown that cigarette smoking increases the infectiousness of tuberculosis patients, the impact of smoking cessation on tuberculosis transmissibility has not been evaluated. Methods Between 2009 and 2012, we enrolled 4500 tuberculosis patients and followed 14 044 household contacts…
Tülin Çağatay, Zeki Kılıçaslan, Aylin Pıhtılı, Züleyha Bingöl, Merih Oray, et al.
Objective: Ocular tuberculosis is still considered to be a controversial issue in terms of both terminology and diagnostic criteria and treatment options. There is no common diagnostic/treatment algorithm even though new approaches exist.In this study, the results of the treatmen…
Mehaffy C, Kruh-Garcia NA, Graham B, Jarlsberg LG, Willyerd CE, et al.
Identification of biomarkers for latent Mycobacterium tuberculosis infection and risk of progression to tuberculosis (TB) disease are needed to better identify individuals to target for preventive therapy, predict disease risk, and potentially predict preventive therapy efficacy.…
The continuing tension of the tuberculosis epidemic situation and the limited information on standard diagnostic methods for latent tuberculosis infection dictate the need to search for methods that allow us to assess with a high level of probability the risk of latent infection …
Ndzi EN, Nkenfou CN, Pefura EWY, Mekue LCM, Guiedem E, et al.
Diagnosis of tuberculosis still faces a lot of challenges and is one of the priorities in the field of tuberculosis management. Deciphering the complex tuberculosis pathogenicity network could provide biomarkers for diagnosis. We discussed the distribution of HLA-B17, -DQB and -D…