Showing 26–50 of 172 documents
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Cao W, Fu X, Li H, Bei J, Li L, et al.
…echnology to conceive. Latent tuberculosis infection during pregnancy has no clinical manifestation, but may develop into active tuberculosis, leading to adverse pregnancy outcomes. Most pregnant women do not need to be treated for latent tuberculosis infection, unless they are c…
M Zhou, X Han, L Jiang
…use of maternal mortality. In vitro fertilization and early pregnancy can reactivate latent TB due to altered cellular immunity. Tuberculosis-related acute respiratory distress syndrome (TB-ARDS) is rare but carries a mortality rate of 60-90%. Extracorporeal membrane oxygenation …
Adriana Weinberg, Lisa Aaron, Grace Montepiedra, Timothy R. Sterling, Nahida Chaktoura, et al.
…, suggesting transient suppression of IFNg responses during pregnancy. Responses to the mitogen-positive QGIT kit control were absent in 60 (7%) women AP, 116 (16%) at L&D, but only 3 (0.4%) PP (P < 0.01), supporting the notion of transient immune suppression during pregna…
Felix Bongomin, Phillip Ssekamatte, Ronald Olum, Diana Sitenda, Davis Kibirige, et al.
**BACKGROUND:** Pregnancy modulates immune responses against() infection. Cytokines, including interleukin-2 (IL-2), play a crucial role incontainment, mainly by inducing the proliferation of T cells. However, the role of IL-2 in latent tuberculosis (TB) infection (LTBI) screenin…
Ainharan Raveendran, Anish Keepanasseril, Ravi Kumar Balu, Ashalatha Shetty, Mahendran Chetty
…tality. With increasing migration, cases of tuberculosis in pregnancy or the puerperium are increasing in resource‐rich nations with advanced health care systems. Diagnosis may be delayed given the overlap of some of the symptoms with that of pregnancy. Timely diagnosis is essent…
PENTA Foundation
…trials of treatments and other interventions. The European Pregnancy and Paediatric Infections Cohort Collaboration (EPPICC) is an international network of researchers working together in this way. Researchers in the network represent cohort studies of pregnant women and childre…
Miele K, Bamrah Morris S, Tepper NK
Tuberculosis (TB) in pregnancy poses a substantial risk of morbidity to both the pregnant woman and the fetus if not diagnosed and treated in a timely manner. Assessing the risk of having Mycobacterium tuberculosis infection is essential to determining when further evaluation sho…
Samantha R. Kaplan, Daniel Matemo, Jerphason Mecha, John Kinuthia, Grace John‐Stewart, et al.
Abstract Background Pregnancy and HIV-associated immunologic changes may affect latent TB infection (LTBI) interferon-gamma release assay (IGRA) QuantiFERON TB Gold Plus (QFT-Plus) diagnostic performance. Methods In this ongoing study, HIV-infected and -uninfected women 20–34 wee…
A. Eswar, Jennifer Kidd, Andrew Fleming, Anju Suhag, Emmanuella Kobara, et al.
…t a case of a 36 year-old female at 19 weeks gestation with pregnancy that was achieved with in vitro fertilization (IVF) with worsening headaches and papilledema due to tuberculosis progression of disease from latent tuberculosis to central nervous system tuberculosis.
Bhosale R, Alexander M, Deshpande P, Kulkarni V, Gupte N, et al.
… among women with and without HIV respectively. Conclusions Pregnancy affects TBI test results and reduces IFN-γ response to M. tuberculosis stimulation. Despite adequate CD4 counts, women with HIV express less IFN-γ than women without HIV, which may explain the high TB incidence…
Kaplan S, Matemo D, Mecha J, Kinuthia J, John-Stewart G, et al.
Abstract Background Pregnancy and HIV-associated immunologic changes may affect latent TB infection (LTBI) interferon-gamma release assay (IGRA) QuantiFERON TB Gold Plus (QFT-Plus) diagnostic performance. Methods In this ongoing study, HIV-infected and -uninfected women 20–34 wee…
Per Bjorkman, MD, PhD
…me countries are at elevated risk of death in connection to pregnancy, as well as infants born to women in such settings. It is probable that several factors are involved, such as poverty, lack of education and access to healthcare. Infectious diseases constitute important threat…
Huashan Hospital
…ortant cause of female infertility in TB-endemic areas. The pregnancy rate of assisted reproductive treatment (ART) in the infertile women with FGTB is still unsatisfied even after receiving standard anti-tuberculosis treatment. Moreover, recent years have witnessed an alarming i…
Jing Li, Qiuli Wu, Weixi Chen, Yanfang Wang, Shiming Xie, et al.
… "latent TB infection" or LTBI) is associated with improved pregnancy outcomes in infertile women undergoing in vitro fertilization and embryo transfer (IVF-ET), and whether outcomes differ by the TPT duration and embryo origin. **METHODS:** All participants initiated the WHO-re…
Zikang Sheng, Lin Zeng, Yue Zhang, Hongbin Chi, Xiaoyan Gai, et al.
…lence. However, the impact of latent TB infection (LTBI) on pregnancy outcomes following assisted reproduction in patients with infertility remains unclear. This systematic review and meta-analysis aimed to assess significant differences in pregnancy outcomes after assisted repro…
Walles J, Otero LG, Tesfaye F, Abera A, Jansson M, et al.
…ca, are disproportionately burdened by stillbirth and other pregnancy complications. Active tuberculosis increases the risk of pregnancy complications, but the association between latent tuberculosis infection (LTBI) and pregnancy outcomes is unknown. We explored the effect of la…
Escudero JN, Mecha J, Richardson BA, Maleche-Obimbo E, Matemo D, et al.
Background Pregnancy and human immunodeficiency virus (HIV) may influence tuberculosis infection detection using interferon (IFN)-γ release assay (QFT-Plus; Qiagen) and tuberculin skin test (TST). Methods Participants in Western Kenya underwent QFT-Plus and TST in pregnancy, 6 we…
Mathad JS, Savic R, Britto P, Jayachandran P, Wiesner L, et al.
Background Pregnancy increases the risk of tuberculosis and its complications. A 3-month regimen of weekly isoniazid and rifapentine (3HP) is safe and effective for tuberculosis prevention in adults and children, including those with HIV, but 3HP has not been evaluated in pregnan…
University of Colorado, Denver
…in to be aware if they are at greater risk of an unintended pregnancy while on the implant. An unintended pregnancy has many social, emotional, and financial impacts on women and society. Rifampin is also a Class C medication for pregnancy and could have potential negative effect…
Yifan Chu, Jialiang Zhang, Luyao Wang, Jiaxin Xie, Jiayun Chen, et al.
…tent tuberculosis infection and ovarian reserve, as well as pregnancy outcomes of in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI), remains poorly understood.A single-center, retrospective cohort study was conducted at the Reproductive Medicine and Genetics Cent…
Li M, Yang X, Zhou Q, Wang J, Wang X, et al.
…cessful pregnancies for some infertility patients. However, pregnancy leads to endocrine and immune function changes that result in decreased immunity, providing an opportunity for mycobacterium tuberculosis infection or reactivation. Hematogenous disseminated pulmonary tuberculo…
König Walles J, Tesfaye F, Jansson M, Tolera Balcha T, Winqvist N, et al.
…TB2), for detection of latent tuberculosis infection during pregnancy. Eight-hundred-twenty-nine Ethiopian pregnant women (5.9% HIV-positive) were tested with QFT-Plus, with bacteriological sputum analysis performed for women with clinically suspected tuberculosis and HIV-positiv…
Joseph A Kovacs, M.D.
…l history, physical exam, and blood tests. Women may have a pregnancy test. During the study, participants must: Use effective birth control Not take most medicine Not drink alcohol At the baseline visit, participants will repeat screening tests and get TAF tablets. Partici…
Noor Hanoush, Lara Abdulmageed, Salahaldin Fahad
…s owing to the certain physiological changes that accompany pregnancy. There is still doubt that pregnancy is a risk factor for the progression of a TB infection (TBI) to a TB illness. Latent TB infection (LTBI), a term used to describe the fact that mycobacterium tuberculosis is…
MS Fonseca-Perez, O Villavicencio-Carrisoza, O Grobeisen-Duque, LA Herrera-Moro-Huitron, A Flores-Pliego, et al.
…ckground: Tuberculosis (TB) poses a significant risk during pregnancy and the postpartum period, with evidence linking these stages to an increased likelihood of progression from latent TB infection to active disease. Although TB has been associated with adverse pregnancy outcome…