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Baucom C, LaPonsie S
Tuberculosis (TB) remains a leading cause of illness and death throughout the world. Despite its high prevalence worldwide, a diagnosis of TB can be hampered by variable clinical presentation, differences in host response, and lack of clinician awareness. In addition to the lungs…
Agarwal A, Kodethoor D, Khanna A, Hanif M
Background India houses 27% of the tuberculosis cases worldwide. Pediatric tuberculosis accounts for 11% cases worldwide. Microbiological confirmation of diagnosis is difficult in children. We aimed to study the proportion of Stool CBNAAT (Cartridge Based Nucleic Acid Amplificati…
Sobia Rasheed, Salma aziz, Irfan Mehmud, Tanzeela Rani, Nur Ul Ain Umair, et al.
INTRODUCTION: Tuberculosis (TB) is a granulomatous infection caused by Mycobacterium tuberculosis. Pakistan ranks 4th globally. Diagnosis is challenging due to children's inability to expectorate sputum and similar symptoms to other respiratory diseases. Rapid detection is crucia…
Nathella Pavan Kumar, Syed Hissar, Arul Nancy, Kannan Thiruvengadam, Velayuthum V Banurekha, et al.
Diagnosing tuberculosis (TB) in children presents significant challenges, necessitating the identification of reliable biomarkers for accurate diagnosis. In this study, we investigated plasma matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) as …
Sevliya Öcal Demi̇r, Sabriye Gülçin Bozbeyoğlu, Kardelen Çeliker
Objective: Early diagnosis of tuberculosis (TB) is important in reducing morbidity and mortality. In this study, we aimed to determine the signs and symptoms that provide the differential diagnosis of TB in pediatric patients. Patients and Methods: The study included children dia…
Miranda-Schaeubinger M, Venkatakrishna SSB, Otero HJ, Marais BJ, Goussard P, et al.
…ographs (CXR) have played an important and evolving role in diagnosis, classification and management of pediatric pulmonary tuberculosis (TB). During the pre-chemotherapy era, CXR aided in determining infectiousness, mainly to guide isolation practices, by detecting calcified and…
Pooja Shah, Sae Pol, E Prabhakaran, Bhakti Karmalkar, Vaishali Gaikwad, et al.
Abstract Background : Tuberculosis (TB) remains a significant public health challenge in developing countries, including India, where children under 15 years account for 12% of all TB cases. The National Tuberculosis Elimination Programme (NTEP) recommends the use of GeneXpert/Ca…
Kashyap B, Gupta N, Dewan P, Hyanki P, Singh NP
… of disease severity, therapeutic response and prognosis in tuberculosis has been suggested. This study aims to determine the levels of high sensitivity CRP (hs CRP) among the pediatric tuberculosis cases. A case control study was conducted on 60 clinically diagnosed (clinical fi…
Lounnas M, Diack A, Nicol MP, Eyangoh S, Wobudeya E, et al.
…atory samples for bacteriological confirmation of childhood tuberculosis but require intensive laboratory processing before molecular testing to remove PCR inhibitors and debris. We aimed to develop a centrifuge-free processing method for use in resource-limited settings based on…
Sreedeep KS, Sethi S, Yadav R, Vaidya PC, Angurana SK, et al.
…vel molecular diagnostic technique that can be used for the diagnosis of tuberculosis (TB). It is most suited for developing countries as it is rapid, inexpensive, highly sensitive, requiring minimal infrastructure, training and manpower. Studies in pediatric TB are lacking. We e…
Singh UB, Singh M, Sharma S, Mahajan N, Bala K, et al.
…e, and sensitive diagnostic assays are essential for global tuberculosis (TB) control, especially in high TB burden, resource-limited settings. The current study was designed to evaluate diagnostic accuracy of Truenat MTB-Rif Dx (MolBio) in children less than 18 years of age, wit…
Urvashi B. Singh, Manjula Singh, Kiran Bala, Abhinav Srivas, Neeraj Mahajan, et al.
…e, and sensitive diagnostic assays are essential for global tuberculosis (TB) control, especially in high TB burden, resource-limited settings. The current study was designed to evaluate diagnostic accuracy of Truenat MTB-Rif Dx (MolBio) in children less than 18 years of age, wit…
Rina Triasih, Amalia Setyati, Dwikisworo Setyowireni, Titik Nuryastuti, Rachma Dewi Isnaini Putri, et al.
…#x0D; Objective To evaluate the use of Xpert MTB/RIF for TB diagnosis in children.
 Methods We conducted a prospective study in Yogyakarta, Indonesia, involving 19 primary health centers (PHCs) and one provincial hospital. Children aged 0-14 years with suspected TB who visit…
Kay A, Garcia-Prats AJ, Mandalakas AM
…pose of review The detrimental synergy of colliding HIV and tuberculosis (TB) epidemics is most devastating among children and adolescents living with HIV (CALWH) who shoulder a disproportionate burden of all child TB mortality. Recent findings CALWH benefit less from Bacille-Cal…
Russo DO, Jimenez ALL, Diniz LMO, Cardoso CA, Romanelli RMC
…ers, delays, and missed opportunities in the prevention and diagnosis of childhood TB. Methods Scoping review according to the PRISMA extension. The definitions considered for the selection followed the acronym PCC where the population (P) is children under 18 years of age with T…
Kissling M, Fritschi N, Baumann P, Buettcher M, Bonhoeffer J, et al.
…to-lymphocyte-ratio (MLR) may have diagnostic potential for tuberculosis (TB). Methods Data of two prospective multicenter studies in Switzerland were used, which included children Results Of the 389 children included 25 (6.4%) had TB disease, 12 (3.1%) TB infection, 28 (7.2%) we…
Luo Y, Yang X, Zhou J, Pu S, Wang Y
The clinical symptoms of tuberculosis infection in children are not typical and need to be distinguished from many diseases, and the tumor is one of them. We present a case of cervical lymphadenopathy in a child with positive purified protein derivative (PPD) and Interferon-Gamma…
Ben J Marais, H Simon Schaaf
Tuberculosis (TB) is a major cause of disease and death in young children from TB-endemic countries, especially in areas affected by poverty, social disruption, and human immunodeficiency virus (HIV) infection. This article reviews the disease burden and the natural history of di…
Goussard P, Retief F, Burke J, Malherbe A, Janson J
… as a diagnostic and therapeutic procedure in children with Tuberculosis (TB) disease complicated by airway obstruction. It is needed in children when surgical intervention may be required for airway compression, when drug resistance is suspected, and to rule out an alternative d…
Jayagandan S, Singh J, Mudliar SR, Shankar P, Maurya AK, et al.
Objective Microbiological confirmation of tuberculosis (TB) in pediatric cases is challenging due to its paucibacillary nature and difficulty in specimen collection. This study aimed to validate stool as an alternative sample for the diagnosis of pediatric pulmonary TB via Xpert …
Ness TE, Meiwes L, Kay A, Mejia R, Lange C, et al.
The WHO has endorsed the use of stool samples for diagnosis of tuberculosis (TB) in children, and targeted next-generation sequencing (tNGS) of stool has been shown to support diagnosis and provide information about drug susceptibility (DS). Optimizing extraction of DNA from stoo…
Emel Aytaç Kaplan, Deniz Akan, Nazan Dalgıç, Emel Ekşi, Özge Yapıcı, et al.
Giri: Bu almann amac, ocukluk a akcier tberklozu tansnda spesifik bilgisayarl tomografi (BT) bulgularn tanmlamaktr
Ilaiwy G, Lukumay S, Augustino D, Mejan P, Bukhay R, et al.
At least a third of tuberculosis (TB) cases remain undiagnosed, disproportionately so in children and adolescents, which is hampering global elimination goals. Prolonged symptom duration presents a high-risk scenario for childhood TB in endemic areas, but the prolonged period of …
Tornheim JA, Madugundu AK, Paradkar M, Fukutani KF, Queiroz ATL, et al.
…kground Gene expression profiling is emerging as a tool for tuberculosis diagnosis and treatment response monitoring, but limited data specific to Indian children and incident tuberculosis infection (TBI) exist. Methods Sixteen pediatric Indian tuberculosis cases were age- and se…
Berlian Beatrix Rarome, Nurul Aisah, Retno Asih Setyoningrum, Ni Made Mertaniasih
The diagnosis of childhood tuberculosis remains a challenge worldwide. The GeneXpert MTB/RIF test, a rapid Mycobacteria tuberculosis diagnostic tool, was recommended for use in children. No pediatric studies of GeneXpert MTB/RIF assessing pulmonary tuberculosis within a hospital …