Showing 26–50 of 157 documents
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Rabyya Jameel, Naima Mehdi, Nadia Majeed, Aizza Zafar, Anum Tahir, et al.
Rifampicin is a primary anti-tuberculosis medication. Diagnosing multidrug-resistant tuberculosis (MDR-TB) remains a persistent challenge when examining both pulmonary and extra-pulmonary samples. Rapid detection of rifampicin resistance is essential for the timely treatment and …
Mostofa Showkat Imran
Background: Tuberculosis (TB) is a common condition all over the world but more common in developing countries like Bangladesh38. This is second only to HIV/AIDS as the greatest killer worldwide due to a single infectious agent. In 2013, 9 million people fell ill with TB and 1.5 …
Hannah-Lena Schäfer, Michael Barker, Peter Follmann, Annette Günther, André Hörning, et al.
Delay in diagnosing multidrug-resistant tuberculosis (MDR-pTB) in children prolongs time to effective treatment. Data on risk factors for pediatric MDR from low-incidence countries are scarce. Retrospective nationwide case–control study to analyze MDR-pTB cases in Germany between…
Jeffrey Hafkin, MD
The purpose of this trial is to determine the pediatric dose of delamanid that is equivalent to the adult dose already shown to be effective against multidrug-resistant tuberculosis. This trial will investigate the pharmacokinetics (PK) and safety of delamanid administered for 1…
S. Maïga, Ali Moussa ML., Tagne M.L., A. Valia, N. Gilbert, et al.
Tuberculosis is a highly contagious infectious disease. It poses a major public health problem. While pulmonary forms are the most frequent in our countries, extra-pulmonary forms are rare in our daily practice. This may be due to their rarity, on the one hand, and to the difficu…
Schäfer HL, Barker M, Follmann P, Günther A, Hörning A, et al.
Delay in diagnosing multidrug-resistant tuberculosis (MDR-pTB) in children prolongs time to effective treatment. Data on risk factors for pediatric MDR from low-incidence countries are scarce. Retrospective nationwide case-control study to analyze MDR-pTB cases in Germany between…
І. В. Ліскіна, С. Д. Кузовкова, Л. М. Загаба, О.D. Nikolaeva
Objective — to clarify the prevalence of tuberculosis infection in HIV-positive inpatients of the TB hospital for 2014—2018 and features of its diagnosis in the affection of the chest cavity organs.Materials and methods. The method of retrospective analysis was used to process me…
Efyluk Garianto, Barkha Agung Priyanto, Benedictus Sebastian Aldorino, Berlian Rutana Pratiwi, Bima Aji Lazuardi, et al.
Introduction: Tuberculosis (TB) is a human disease caused by Mycobacterium tuberculosis. The bacteria is a rod-shaped and acid-resistant, hence it is also known as acid fast Bacilli. The disease mainly affects the lungs, making pulmonary disease the most common presentation of Tu…
Epperson K, Crane C, Ingulli E
Donor derived infections (DDIs) in pediatric kidney transplant recipients remain challenging to diagnose and can result in serious morbidity and mortality. This review summarizes the current guidelines and recommendations for prevention, diagnosis, and treatment of unexpected DDI…
И. С. Долгополов, O. B. Federiakina, O. M. Volzhenina, G. G. Erokhina, K. A. Leonov, et al.
Congenital tuberculosis is a fatal disease in the absence of treatment. The diagnosis is difficult due to polymorphic and nonspecific symptoms in neonates, as well as the lack of alertness of neonatologists and pediatricians. Less than 500 confirmed cases of congenital tuberculos…
Dong-Mei Wang, Qi An, Qing Yang, Yi Liao
…To describe the demographic and clinical characteristics of pediatric tuberculosis (TB) inpatients diagnosed with resistance to any anti-tuberculosis drug [drug-resistant tuberculosis (DR-TB)] in southwest China. **METHODS:** Patients aged ≤14 years with clinically…
Vikas Marwah, Gaurav Bhati, Robin Chaudhary, Anmol Sharma
Background: Pulmonary tuberculosis (PTB) is an established cause of arterial and venous thrombosis. With the rising incidence of multidrug-resistant tuberculosis (MDR TB), which has a prolonged treatment course, pulmonary thromboembolism in such cases further complicates the trea…
Zhang Y, Zhao R, Zhang Z, Liu Q, Zhang A, et al.
Objective Pediatric tuberculosis (TB) is one of the top ten causes of death in children. Our study was to analyze influencing factors of multidrug-resistant tuberculosis (MDR-TB) and validation of whole-genome sequencing (WGS) used in children with drug-resistant TB (DR-TB). Meth…
О. М. Raznatovska, A. S. Moskaliuk, Тетяна Анатоліївна Грекова, L. I. Chernyshоva, O. O. Pushnova, et al.
…th Organization (WHO) reports an unknown contact history of pediatric tuberculosis (TB), especially in children younger than 5 years old. Tracing pediatric household contacts of patients with multidrug-resistant TB (MDR-TB) is considered to be a highly effective intervention for …
Dhruv Gandhi, Ira Shah
…Xpert Ultra, and Xpert MTB/XDR, are critical for diagnosing pediatric tuberculosis (TB) and detecting drug resistance. However, rifampicin indeterminate (RI) results, particularly in samples with trace Mycobacterium tuberculosis (MTB) load, pose a clinical challenge. Current guid…
Hannah Schäfer, Michael Barker, Peter Follmann, Annette Günther, Petra Kaiser‐Labusch, et al.
<b>Background:</b> Diagnosis and treatment of paediatric tuberculosis resistant to both isoniazid and rifampicin (MDR-pTB) remain challenging due to paucibacillary disease, low sensitivity and specificity of diagnostic tools and frequently changing guidelines <b>Aims and objectiv…
Titiek Sulistyowati, Deby Kusumaningrum, Eko Budi Koendhori, Ni Made Mertaniasih
Background: Tuberculosis continues one of the major challenges to global health. Mycobacterium tuberculosis complex can affect any organ other than the lung parenchyma, include central nervous system. The mortality rate of tuberculous meningitis (TBM) are high worldwide with up t…
Oana Mihailov, I.D. Rădulescu, Raul Mihailov, Anamaria Ciubară
Introduction When depression is comorbid with tuberculosis, it will lead to decreased quality of life, lack of adherence to anti-Tb drugs, progression to MDRTB and will end in death with mortality from the disease. Objectives We aimed to study the association of Tuberculosis and …
Schaaf HS
…oximately 25,000 children develop multidrug-resistant (MDR) tuberculosis (TB) each year, but few of them are diagnosed and appropriately treated for MDR-TB. New diagnostic tools have improved our ability to diagnose children with bacteriologically confirmed TB earlier. However, t…
Roya-Pabón C, Restrepo A, Morales O, Arango C, Maya MA, et al.
Tuberculosis (TB) in the pediatric population is a major challenge. Our objective was to describe the clinical and microbiological characteristics, radiological patterns, and treatment outcomes of children and adolescents (from 1 month to 17 years) with community-acquired pneumon…
Vilius Kerpauskas, Vaiva Kručiūtė, Jovita Randakevičienė
…ion Tuberculous meningoencephalitis (TBM) is a rare form of tuberculosis. Despite advances in diagnostics and treatment, TBM has a high mortality rate and requires timely intervention to reduce long term neurological complications [1,2]. This clinical case highlights the challeng…
Safae Elfirdaous Fari, M. Maamar, Khibri Haja, Nisserine Jait, Y. Moussadik, et al.
<i>Introduction: </i>Tuberculosis (TB) is a pathology considered one of the main causes of death by single infectious agent, ranking just after HIV / AIDS. Indeed, its emergence and the difficulty of its treatment, especially in the resistant form, in patients with co-infection w…
Yusup Subagio Sutanto, Paulus Wisnu Kuncoro Murti, Reviono Reviono, Ari Probandari, Hendra Kurniawan
…y aims to determine the factors that influence the delay in diagnosis and treatment of MDR-TB patients. Subjects and Method: This study was a cross-sectional study conducted at Dr. Moewardi hospital, from September to October 2017, Surakarta, Central Java. A sample of 73 MDR-T…
Phan Tuan Duc, Bui Son Nhat, Le Thi Luyen
…zinamide was established based on the data of 129 pulmonary tuberculosis patients in 3 hospitals: Hanoi Lung Hospital, K74 Hospital, and Central Lung Hospital. Blood samples were obtained on the 10-14th day after initiation of treatment. Time-concentration data were incorporated …
О.М. Калечиц, Alena Skrahina, Dzmitry Klimuk, Е.Л. Бобрукевич, А.Ф. Белько, et al.
… being developed that are registered at dispensary in anti- tuberculosis organizations, where a place will be reserved for patients with relapses of tuberculosis, taking into account data from social and medical characteristics, and complex rehabilitation measures. Objective of t…