Showing 26–50 of 200 documents
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…ackground Understanding barriers and facilitators to latent tuberculosis infection (LTBI) diagnosis and care is needed to successfully treat children/adolescents with LTBI in the US. We explored physicians’ perspectives on pediatric LTBI diagnosis and care, and strategies to impr…
Jeffrey I. Campbell, Yamini Adusumelli, Mary Tabatneck, Susan N. Sherman, Gabriella S Lamb, et al.
…ackground Understanding barriers and facilitators to latent tuberculosis infection (LTBI) diagnosis and care is needed to successfully treat children/adolescents with LTBI in the US. We explored physicians’ perspectives on pediatric LTBI diagnosis and care, and strategies to impr…
Ndzi EN, Nkenfou CN, Mekue LM, Zentilin L, Tamgue O, et al.
The diagnosis of tuberculosis (TB) continues to pose substantial public health problems. The quest for diagnostic biomarkers for TB is therefore primordial. This study aimed to evaluate the diagnostic and anti-TB treatment monitoring potentials of some selected miRNAs. Quantitati…
Nordholm AC, Holden IK, Hartling UB, Andersen PH, Lillbaek T, et al.
Background In Western Europe, most pediatric tuberculosis (TB) cases occur among immigrants; however, data are rarely stratified by first/second-generation immigrants and many cases may be preventable. Methods This was a nationwide study of children Results We identified 145 case…
Layla Silveira, Williane Fernandes, A Monteiro, Livia Valle, Amanda Soares, et al.
BACKGROUND: Perinatal Tuberculosis (TB) is a rare disease, transmitted during pregnancy or postnatal. Its clinical presentation is similar to congenital infections and neonatal sepsis, thus, remains underestimated and underdiagnosed. CASE PRESENTATION: A 34 week female child, bor…
Starshinova A, Zhuravlev V, Dovgaluk I, Panteleev A, Manina V, et al.
Background The WHO strategy for eradication of tuberculosis (TB) by 2035 (The End TB Strategy) is aimed at an early and precise diagnosis and subsequent effective treatment of TB patients. Currently, there is no gold standard for the diagnosis of latent TB infection. This study e…
Jeffrey I. Campbell, Thomas J. Sandora, Jessica E. Haberer
… estimated 1 million children develop and ~200,000 die from tuberculosis (TB). The WHO has named identification and treatment of latent tuberculosis infection (LTBI) one of the cornerstones of efforts to eliminate TB by 2030. Identification and treatment of pediatric LTBI require…
Jia J, Chen D, Liu L, Siddiqui MJ, Yang F, et al.
Background China has a high burden of tuberculosis and latent tuberculosis infection (LTBI). The aim of this study was to estimate the prevalence of LTBI among healthy young children and adolescents and test a 2-step approach to explore the threshold for the diagnosis of tubercul…
Sofia Kostoudi, Robert Hammond
ABSTRACT Background Tuberculosis (TB) is the second leading infectious killer after COVID-19 and the 13 th leading cause of death worldwide. Latent tuberculosis (LTBI) has become a major pool of potential active tuberculosis cases and is propelling the TB global health burden fur…
Campbell J, Sandora T, Haberer J
… estimated 1 million children develop and ~200,000 die from tuberculosis (TB). The WHO has named identification and treatment of latent tuberculosis infection (LTBI) one of the cornerstones of efforts to eliminate TB by 2030. Identification and treatment of pediatric LTBI require…
Wendorf KA, Lowenthal P, Feraud J, Cabanting N, Murto C
…nterferon-γ release assays (IGRAs) in children ≥2 years for diagnosis of latent tuberculosis infection (LTBI). However, lack of experience in young children and concern that IGRAs are less sensitive than tuberculin skin tests (TSTs) limit their use. Our aim was to identify active…
Beuy Joob, Viroj Wiwanitkit
… “Performance of Interferon-Gamma Release Assay (IGRA)s for Tuberculosis Screening in Pediatric Inflammatory Bowel Disease” with great interest (1). Stevens et al noted that “IGRA's are a useful tool to screen for LTBI, both prior to anti-TNF therapy and during treatment (1).” Th…
Carvalho ACC, da Silva Martins P, Cardoso CAA, Miceli AL, Martire T, et al.
…acteristics, diagnostic approach, and treatment outcomes of tuberculosis (TB) in children living in a high-burden metropolitan area. Methods This was a retrospective study, based on a medical chart review, involving children under 15 years old treated for TB between 2007 and 2016…
M. E. Lozovskaya, Yu. А. Yarovaya, E. В. Vasilieva, L. N. Khamchieva, Anna Mosina, et al.
…nation of hereditary pathology – Gaucher disease and latent tuberculosis infection in an 8-y ea r-o ld child. The child was examined for tuberculosis due to disseminated small foci and calcination in the lung tissue detected by chest computed tomography. The particular parameter …
Brinkmann F, Hofgrefe J, Ahrens F, Weidemann J, Berthold LD, et al.
Background The differentiation between latent tuberculosis infection (LTBI) and tuberculosis (TB) relies on radiological changes. Confirming the diagnosis remains a challenge because typical findings are often missing in children. This study evaluates diagnostic sensitivity, spec…
Magdalena D, Michal S, Marta S, Magdalena KP, Anna P, et al.
Profound tuberculosis (TB)-induced metabolic changes reflected in the blood metabolomic profile may provide an opportunity to identify specific markers of Mycobacterium tuberculosis infection. Using targeted liquid chromatography tandem mass spectrometry, we compared the levels o…
Vaiva Šiuparytė, Justina Žvikevičiūtė, Vaida Kudirkienė
Introduction Tuberculosis (TB) in children receiving immunosupresants, such as tumor necrosis factor α inhibitors (TNFis), is rare; however, these patients are at an increased risk for severe TB disease and significant long-term morbidity [1]. We present a case of disseminated TB…
James P. Stevens, Cortney R. Ballengee, Raguraj Chandradevan, Amelia B. Thompson, Bess T. Schoen, et al.
…ts negative predictive value, moreover, was 99.9%. Multiple pediatric studies with a larger number of patients positive for tuberculosis have demonstrated IGRAs to have a higher sensitivity than TST (1,2). TSTs suffer from the subjectivity of the individual interpreting the skin …
A A Amaral Ibiapina Parente, L De Melo Lima, R Baroni Aurílio, A Rodrigues Fonseca, F Sztajnbok, et al.
…ground:</b> Patients with rheumatic diseases have more tuberculosis (TB) but are few studies about TB and latent tuberculosis (LTBI) in pediatric subjects with those diseases. Objectives:Describe subjects with rheumatic diseases and diagnosis of TB or LTBI in a pediatric&nbs…
Wattal C, Raveendran R
The diagnosis of childhood tuberculosis is a challenge due to the pauci-bacillary nature of infection and the difficulty in obtaining appropriate sample. In the past 2-3 decades, many new tests were introduced for the diagnosis of tuberculosis (TB) and some of them have been eval…
Ayling Sanjaya
Background: Pediatric tuberculosis (TB) is a major health problem in the world and Indonesia. The difficulty of diagnosis is a major factor in eradicating TB in children. Active and latent tuberculosis in children often shows no symptoms so it is difficult to diagnose and affect …
Lauren E. Kushner, Vidya Mony, David M. Vu
…ckground For foreign-born children from countries with high tuberculosis (TB) burden, positive tuberculin skin test (TST) results, associated with Bacillus Calmette Guerin (BCG) vaccination, paradoxically increase the risk for overdiagnosis and overtreatment of latent TB infectio…
Hyejin So, Jina Lee
Abstract Background Pediatric hematopoietic stem cell transplantation (HSCT) recipients are one of the high-risk groups concerning tuberculosis and screening for latent tuberculosis infection (LTBI) prior to HSCT is important and accurate diagnostic tests for predicting LTBI in t…
Böncüoğlu E, Kıymet E, Şahinkaya Ş, Akaslan Kara A, Çağlar İ, et al.
…antiFERON®-TB Gold Plus) and tuberculin skin test (TST) for tuberculosis infection were included in the study. Underlying medical conditions of the patients were recorded. Cohen's κ was run to determine if there was an agreement between TST and IGRA. Results A total of 220 patien…
Said K, Hella J, Ruzegea M, Solanki R, Chiryamkubi M, et al.
Background Childhood tuberculosis (TB) is acquired after exposure to an infectious TB case, often within the household. We prospectively screened children 6-59 months of age, exposed and unexposed to an infectious TB case within the same household, for latent tuberculosis infecti…