Showing 26–50 of 107 documents
Sorted by hybrid relevance (keyword + semantic via RRF)
Pirmahmadzoda B, Hann K, Akopyan K, Grigoryan R, Geliukh E, et al.
Introduction Approximately 3% of all pediatric TB cases develop MDR-TB, with only 3-4% of such children receiving MDR-TB treatment. In Tajikistan, children as a proportion of all DR-TB in the country increased from 4.3 to 7.5% during 2013-2018. Despite limited evidence on the use…
Patra J, Irving H, Maini P, Liang J, Patra A, et al.
…XDR- tuberculosis (TB) account for approximately a third of pediatric MDR-TB cases globally. Clinical management is challenging; recommendations are based on limited evidence. We assessed the clinical outcomes for children and adolescents treated for XDR-and pre-XDR-TB. We perfor…
Unnati Desai, Jyotsna Joshi, Parikshit Thakare, Ketaki Utpat
…1 years; there were 57 males. Mean body weight was 41.8 kg. Pediatric patients (age 12-17) constituted 13%. All the patients had pulmonary TB. Of the 100 cases, 80 were Category IV failure; 5% were defaulters of Category IV; and 15% were treated with second-line drugs adequately …
Muhammad Kashif Munir
…which improved sensitivity, particularly in smear-negative, pediatric, and extrapulmonary cases1. Yet the most significant recent milestone has been the introduction of GeneXpert MTB/XDR. This assay detects resistance not only to rifampicin and isoniazid but also to fluoroquinolo…
Francesca M Conradie
BEAT Tuberculosis is a phase 3, open label, multi-centre, randomized controlled trial. The purpose of this trial is to compare the efficacy and safety of a Study Strategy consisting of 6 months of bedaquiline (BDQ), delamanid (DLM), and linezolid (LNZ), with levofloxacin (LVX) an…
Kavina Manalan, L Altass, T Capstick, S Coles, G Davies, et al.
<h3>Background</h3> The UK BTS MDRTB CAS provides an on-line forum and a monthly virtual multi-disciplinary meeting of TB experts to provide advice for drug-resistant or complex cases of TB but also encompassing detailed WGS information and public health advice. This service also…
MCI Lipman, L Altass, T Capstick, G Davies, P Haldar, et al.
<h3>Introduction and Objectives</h3> The BTS Multidrug Resistant (MDR) Tuberculosis (TB) Clinical Advice Service (CAS) provides an electronic forum to review, discuss and record formal feedback through an MDT delivered by national experts for cases of MDR and complex TB, submitte…
Suvash Chandra Roy, Parvin Akter Khanam, Be Nazir Ahmed, Md Azizul Islam, AKM Faizul Huq, et al.
Introduction: Every year millions of people fall sick with Tuberculosis (TB). Multidrug-resistant tuberculosis (MDR-TB) has a life threatening public health crisis globally. Objective: To determine the successful treatment outcomes of MDR-TB in Bangladeshi population. Methods: Th…
Winnery Dhestina, Prayudi Santoso, Edhyana Sahiratmadja
As the third-highest country with tuberculosis (TB) incidence worldwide in 2020, Indonesia has increasing TB cases resistant to various anti-TB therapy or multidrug-resistant (MDR)-TB, and ranked fifth for its high incidence reported in Global Tuberculosis Report 2020. Moreover, …
Soumya Bhattacharjee
Background: Extensively drug-resistant TB is still a serious challenge in India, and before the introduction of new anti-tuberculosis drugs these patients were treated with a conventional regimen for XDR-TB according to the guidelines of RNTCP at that time for almost 24 to 36 mon…
Zarir Udwadia, Palak P. Patel, Samridhi Sharma, Amita Gupta, Jeffrey A. Tornheim
Background Multidrug-resistant tuberculosis (MDR-TB) represents a significant clinical and public health challenge worldwide. Out of concern for possible resistance, some providers prescribe first- and second-line tuberculosis treatment together before completing drug susceptibil…
Sonisha Gupta, Ankur Porwal, Atul Gupta
Tuberculosis (TB) is, one of the top 10 causes of death worldwide and the leading cause of death from a single infectious agent. This Prospective study was conducted at Santosh medical college Ghaziabad from 1 April 2018 to 30 September 2019. All diagnosed PTB patients above 12yr…
Inna Friesen, Timo Ulrichs, L. A. Hryshchuk, H. S. Saturska
Objective — to compare the epidemiological situation of chemoresistant tuberculosis in Germany and Ukraine, in addition analyzing the nature and features of chemoresistant tuberculosis in 192 patients treated at the Ternopil Regional TB Dispensary Ukraine during 2017—2018.
 …
Л. В. Панова, E. S. Ovsyankinа, E. A. Krushinskaya, A. Yu. Khiteva, О. А. Пискунова
The objective of the study: to evaluate the efficacy and safety of short course chemotherapy regimens for multiple/extensive drug resistant tuberculosis of the respiratory system (MDR/XDR) in older children and adolescents. Subjects and Methods. A cohort prospective controlled stud…
S Koirala, Nayab Shah, Prajjwal Pyakurel, Manish Khanal, Sagar Kumar Rajbhandari, et al.
SETTING: Nine drug-resistant TB centres, some of them supported by Damien Foundation in Nepal where >80% of multidrug-resistant/rifampicin-resistant TB (MDR/RR-TB) patients are treated. OBJECTIVE: To assess the uptake, effectiveness and safety of the 9-12-month shorter treatment …
Neela D. Goswami, Lakshmi Praveena Peddareddy, John Jereb, Angel Colon Semidey, Elaine Darnall, et al.
Abstract Background In August 2019 the U.S. FDA approved pretomanid as part of a 6-month all-oral BPaL (bedaquiline, pretomanid, and linezolid) regimen for treating pulmonary extensively drug-resistant (XDR) or treatment-intolerant or nonresponsive multidrug-resistant (MDR) tuber…
Valentina Aksenova, Н. И. Клевно, А. И. Казаков, D.А. Kudlаy, А. Д. Пахлавонова, et al.
Introduction. The treatment of children with multidrug-resistant and extensively drug-resistant tuberculosis (MDR / XDR-TB) is a difficult task due to many factors: the duration of treatment, the lack of drugs with children’s dosages, age restrictions (according to the drug instr…
Neil Sharma, Manish Singhal, Rachana Agrawal, Manoj Kumar Sharma, Sona Goyal
Context: Tuberculosis is a major health problem in India .Accurate and also fast diagnosis of tuberculosis has remained a challenge and we determined the impact of CBNAAT on notification of tuberculosis cases in Rajasthan. Aims: The Aim of the present Study was use of CBNAAT in t…
Ricardo Cordeiro, M.J. Cavaco, Carina Rôlo Silvestre, André Nunes, João Otávio de Queiroz Araujo, et al.
<b>Aims and objectives:</b> Currently, there is still limitations of evidence to draw any recommendations on XDR-TB contacts preventive therapy. This study aimed to identify the patterns of the transmission of an XDR-TB case among household contacts from 2010 to present date. <b>…
Poulomi Chatterjee, Vipin Kumar Goyal, Kapil Sharma, Sonia Hasija
<b>Background:</b> India has the notorious distinction of being the country with maximum incidence of MDRTB. Nuh district in North India has one of the highest incidence of MDRTB in India. We studied the treatment outcome of diagnosed Multi-Drug Resistant tuberculosis in this dis…
Yash Jagdhari, Ajay Kumar Verma, Surya Kant, Richa Mishra, Kanchan Srivastava, et al.
<b>Introduction:</b> Insight into the clinical characteristics and mutational profile of XDR TB cases is essential to reduce the incidence and effectively treat the cases of XDR TB, which has remained a challenge. <b>Aim:</b> To identify the clinical and mutational profile in cas…
Leningrad Oblast Regional Anti-Tuberculosis Dispensary, Slantsy, Slantsevsky District, Leningrad Oblast, Russia, N.A. Barmina, Yu.V. Korneev, Leningrad Oblast Regional Anti-Tuberculosis Dispensary, Slantsy, Slantsevsky District, Leningrad Oblast, Russia
The epidemiological situation of tuberculosis (TB) has been improving steadily in recent years however, in the structure of TB patients, there is a high proportion of patients with multidrugresistant/extensively drug-resistant (XDR) pathogens and people with HIV and TB co-infecti…
Kahaf Khan, Ayaz Ali Unar, Khalida Unar, Faraz Qurban Rajper, Mirza Tasawar Baig
The objective of the study is to evaluate of drug resistance and treatment outcomes among tuberculosis patients with diabetes mellitus at tertiary care hospital of Sindh, Pakistan. Tuberculosis (TB) is considered as very dangerous infectious disease caused by Mycobacterium tuberc…
Neelima Sharma, Arjun Khanna, Shivani Chandra, Saurav Basu, Kanwaljit Chopra, et al.
Background: Multidrug-resistant tuberculosis (MDR-TB) referring to tuberculosis that is resistant to both rifampicin and isoniazid is a major challenge against meeting TB elimination targets. We conducted this operational research study with the objective of describing MDR-TB tre…
Krishna Mohan, Aftab Alam, Ranjana Patnaik
Drug-resistant tuberculosis (DR-TB) is a problem that dissuades the tuberculosis control and prevention efforts worldwide. A big portion of the world’s TB burden is seen in India. We aimed to produce valuable evidence on the prevalence and patterns of DR-TB pan India for a period…