Showing 26–50 of 200 documents
Sorted by hybrid relevance (keyword + semantic via RRF)
Tom Sumner, Rebecca A. Clark, Christinah Mukandavire, Allison Portnoy, Chathika K. Weerasuriya, et al.
Abstract Background Tuberculosis remains a major public health problem in South Africa, with an estimated 300,000 cases and 55,000 deaths in 2021. New tuberculosis vaccines could play an important role in reducing this burden. Phase IIb trials have suggested efficacy of the M72/A…
Sumner T, Clark RA, Mukandavire C, Portnoy A, Weerasuriya CK, et al.
Background Tuberculosis remains a major public health problem in South Africa, with an estimated 300,000 cases and 55,000 deaths in 2021. New tuberculosis vaccines could play an important role in reducing this burden. Phase IIb trials have suggested efficacy of the M72/AS01 E vac…
Sonawane C, Yirga G, Carter NH
…anthropogenic waste for food can remove pathogens that pose health risks to humans and livestock, thereby saving lives and money. Quantifying these benefits is rare, yet can lead to innovative conservation solutions. To assess these benefits, we examined the feeding ecology and p…
Mao JJ, Zang X, Yue WL, Zhai PY, Zhang Q, et al.
…in a phase III trial. We aim to assess the population-level health and economic impacts of introducing Vaccae vaccination to inform policy-makers. Methods We evaluated a potential national Vaccae vaccination programme in China initiated in 2024, assuming 20 years of protection, 9…
Clark RA, Weerasuriya CK, Portnoy A, Mukandavire C, Quaife M, et al.
…ulation-level impact are needed. We estimated the potential health and economic impact of M72/AS01 E and BCG-revaccination in India and investigated the impact of variation in vaccine characteristics and delivery strategies. Methods We developed an age-stratified compartmental tu…
Rebecca A. Clark, Allison Portnoy, Chathika K. Weerasuriya, Tom Sumner, Roel Bakker, et al.
…ence. We used mathematical modelling to investigate how the health and economic impact of two potential tuberculosis vaccines, M72/AS01 E and BCG-revaccination, could differ in Delhi and Gujarat under varying delivery strategies. Methods We applied a compartmental tuberculosis mo…
Allison Portnoy, Rebecca A. Clark, Matthew Quaife, Chathika K. Weerasuriya, Christinah Mukandavire, et al.
…mic models, calibrated to demographic, epidemiological, and health service data in 105 LMICs. For each country, we assessed the likely future course of TB-related outcomes under several vaccine introduction scenarios, compared to a ‘no-new-vaccine’ counterfactual. Key economic in…
Pareek M, Eborall HC, Wobi F, Ellis KS, Kontopantelis E, et al.
…alitative sub-study to understand the views of migrants and healthcare professionals to the new testing policy in primary care. Finally, we will evaluate the cost-effectiveness of combined infection testing for migrants in primary care. Ethics and dissemination The study has rece…
Davide Rasella, Otávio T. Ranzani
…en shown to be detrimental for a wide range of diseases and health conditions, especially in low-income and middle-income countries (LMICs).1Backhaus I Hoven H Di Tecco C Iavicoli S Conte A Dragano N Economic change and population health: lessons learnt from an umbrella review on…
Juliet G Nyamasve, Nyaradzai A Katena, Shepherd Shamu, Junior Mutsvangwa, Aliasgar Esmail
…diagnosis is critical for reducing morbidity, mortality and health system costs, economic evaluations of EPTB diagnostics remain sparse and fragmented. This protocol aims to map existing evidence on the economic evaluation of diagnostic innovations for EPTB in low-resource settin…
de Necker M, de Beer JC, Stander MP, Connell CD, Mwai D
…ients on ARVs. Like many resource limited settings, Kenya's healthcare system faces serious challenges in effectively providing quality health services to its population. Increased investments to strengthen the country's capacity to diagnose, monitor and treat diseases, particula…
Lissa Aoki, Juliana de Carvalho Rodrigues, Ingrid Bertollini Lamy, Gláucia Luciano da Veiga, Beatriz da Costa Aguiar Alves, et al.
… analyzed the impact of the COVID-19 pandemic using DATASUS health data and assessed the influence of socioeconomic interventions (SAGICAD data) on tuberculosis and leprosy case notifications in Brazil. A correlation analysis was performed between regional diagnoses and variables…
Yue WL, Zhai PY, Mao JJ, Ma JF, Ren WL, et al.
Abstract Introduction Tuberculosis (TB) is a major global health issue, particularly, in India and South Africa. We aim to evaluate the potential of the new TB vaccine, Vaccae, to enhance TB control by integrating with active case finding (ACF) strategies in these regions. Method…
Hailu G, Etefa M, Begna F
…bacterium tuberculosis complex, highly impacting the public health and economy of the country in endemic areas. Retrospective and cross-sectional study was conducted between March and August 2021. For knowledge, attitude, and practices study, five villages were randomly selected …
Marcia R. Weaver, Carol Levin, Edina Sinanovic
Reviewers: M Weaver (University of Washington) | 📗📗📗📗◻️ • C Levin (University of Washington) | 📒📒📒◻️◻️ • E Sinanovic (University of Cape Town) | 📘📘📘📘📘
Pei-Yao Zhai, Xiao Zang, Ting Jiang, Jian Feng, Bin Zhang, et al.
**BACKGROUND:** China faces high burden of multidrug-resistant or rifampicin-resistant tuberculosis (MDR/RR-TB). We aimed to evaluate the impacts of Vaccae vaccination and enhanced drug-resistant TB (DR-TB) management strategies. **METHODS:** Using a compartmental model calibrat…
Clark RA, Portnoy A, Weerasuriya CK, Sumner T, Bakker R, et al.
Background India has the largest tuberculosis burden, but the all-age prevalence in 2021 ranged from 747/100,000 in Delhi to 137/100,000 in Gujarat. No modelling studies have compared the potential impact of new tuberculosis vaccines in regions with differing disease and infectio…
Claborn DM
… of a country's economy can have significant impacts on the health and healthcare infrastructure of the country. This paper compares the collapse of three national economies from widely separated regions: Venezuela, Zimbabwe, and the countries of the former Soviet Union. Despite …
Jiang T, Chen XS
…istance (AMR) has become a global threat to not only public health impacts but also clinical and economic outcomes. During the past decades, there have been many studies focusing on surveillance, mechanisms, and diagnostics of AMR in infectious diseases but the impacts on public …
Goryoka GW, Lokossou VK, Varela K, Oussayef N, Kofi B, et al.
…se a significant threat to human, animal, and environmental health. The Economic Community of West African States (ECOWAS) has endured a significant burden of zoonotic disease impacts. To address zoonotic disease threats in ECOWAS, a One Health Zoonotic Disease Prioritization (OH…
Jiaying Stephanie Su, Stover John, Carel Pretorius, Peter Winskill, Sedona Sweeney, et al.
…stments to combat HIV, tuberculosis and malaria for primary health care, 2000–2023: an economic modeling analysis"
World Health Organization
… from a technical consultation convened by the Alliance for Health Policy and Systems Research and the WHO Department of Health Financing and Economics in March 2025 on sustaining essential health service coverage amid growing health financing constraints. The report examines the…
Tom Wingfield, Stéphane Verguet
…programmes (NTP).1WHOGlobal Tuberculosis Report 2018. World Health Organization, Geneva2018Google Scholar Of the remaining 6 million, many experienced substantial delays in accessing and receiving appropriate care.1WHOGlobal Tuberculosis Report 2018. World Health Organization, Ge…
Jiaying Stephanie Su, John Stover, Carel Pretorius, Peter Winskill, Sedona Sweeney, et al.
… tuberculosis, and malaria (HTM) have delivered substantial health gains and may have reduced the burden placed by these diseases on the routine health system. We estimated the reduction in primary healthcare (PHC) utilization resulting from the scale-up of HTM services over 2000…
Schäferhoff M, Zimmerman A, Diab MM, Mao W, Chowdhary V, et al.
…inical trials, trial sites, and production capacity for new health products could improve access to vaccines, therapeutics, and infectious disease diagnostics in middle-income countries. This study assesses the case for such investment in three of these countries: India, Kenya, a…