Showing 26–50 of 200 documents
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Sonia Islam Khan
… narrative review explores the current understanding of the epidemiology, clinical features, diagnostic approaches, and challenges related to treatment failure in TB. Globally, an estimated 10 million new TB cases and 1.3 million TB-related deaths were reported in 2022, with the …
Fadzil FA, Ramli SR, Neoh H
…s the timeline of pulmonary tuberculosis (PTB) in Malaysia, epidemiology, management and outlook of the disease in the country. PTB was first reported in Malaya in the early 20th century and caused high morbidity and mortality. With the establishment of the National TB Control Pr…
Afsaneh Kaffash, Saeideh Sadat Shobeiri, Elham Pouraslan, Asghar Kazemzadeh, Fatemeh Doost Mohammadi, et al.
**OBJECTIVE:** This ecological study examines epidemiological trends in tuberculosis, multidrug-resistant TB, extensively drug-resistant TB, and latent TB infection across Iran and its provinces from 1990 to 2021, and explores their association with the Human Development Index. …
Wang DM, Li QF, Zhu M, Wu GH, Li X, et al.
Background Sichuan is a province located in southwestern China, which have a higher incidence of tuberculosis (TB). This study aimed to analyze the epidemiological and clinical characteristics, as well as drug resistance in culture-confirmed children with Tuberculosis meningitis …
T. D. (Tosheva) Rakhmatovna
Extensively drug-resistant tuberculosis (XDR-TB) represents a serious threat to global public health, especially in resource-limited countries. This paper reviews current data on the prevalence, mechanisms of resistance, and clinical-epidemiological features of XDR-TB, as well as…
Medina
With 5,000 new active cases each year, tuberculosis in Chile remains as the most important communicable disease in the country. Since the type of control programs are linked to the epidemiologic situation as far as infection, morbidity and mortality are concerned, an effective su…
Neel R Gandhi, Kogieleum Naidoo, Keeren Lutchminarain, Shaheed V Omar, Hikari Yoshii, et al.
**RATIONALE:** Transmission is the primary driver of tuberculosis (TB) and drug-resistant (DR) TB in high-burden countries; however, where and between whom spread occurs is poorly understood. **OBJECTIVE:** We conducted universal whole genome sequencing (WGS) to evaluate the rol…
Tiberi S, Tiberi S, Zumla A, Migliori GB
…ealth care continue to hamper efforts. This article reviews epidemiology, clinical features, management, and treatment, with new updates and recent changes in guidelines that offer patients better tolerated and shorter regimens for enabling therapeutic outcomes.
Gizachew Taddesse Akalu, Belay Tessema, Waganeh Sinshaw, Misikir Amare, Getu Diriba, et al.
Abstract Background Conventional wisdom wrongly holds that the microbiological of M. tuberculosis complex in clinical specimens via culture and phenotypic drug susceptibility testing allows people to be correctly diagnosed and ensures an effective treatment regimen to be selected…
Azfar A. Ishaqui, Salman A. Ahmad, Shoaib Alam, Narendar Kumar, Javeria Farooq, et al.
Objectives: Tuberculosis (TB) continues to drive infectious mortality worldwide. The study characterized the evolution of drug-susceptible TB (DS-TB), multidrug-resistant TB (MDR-TB), and extensively drug-resistant TB (XDR-TB) in 30 WHO high-burden countries, linking current patt…
Safaa Alkhawaja
Introduction: Tuberculosis (TB) remains a major cause of morbidity and mortality worldwide, drug resistance is one of the major contributors to that. No existing published data about the burden of Multi-Drug Resistant (MDR) TB in the kingdom of Bahrain, the aim of our study is to…
Thinley Dorji
Introduction: Multidrug resistant tuberculosis (MDR-TB) is defined as a case of tuberculosis resistant to rifampicin and isoniazid which are the first line anti tuberculosis drugs. Globally emergences of MDR-TB possess a challenge to TB control. In Bhutan, the proportion of MDR-T…
A. S. (Abdullaeva) Sh
A third of the world's population is infected with Mycobacterium tuberculosis (MTB) and more than 9 million cases of tuberculosis (TB) are diagnosed annually, resulting in almost 2 million deaths each year (WHO., 2015). TB accounts for more than a quarter of all preventable death…
Hurtado J, Coitinho C, Nin N, Buroni M, Hurtado FJ, et al.
Human tuberculosis is still a major world health concern. In Uruguay, contrary to the world trend, an increase in cases has been observed since 2006. Although the incidence of MDR-resistant strains is low and no cases of XDR-TB were registered, an increase in the number of patien…
Wu B, Yu Y, Du C, Liu Y, Hu D
China is one of the top 30 countries with high multidrug-resistant tuberculosis (MDR-TB) and rifampin-resistant tuberculosis (RR-TB) burden. Chongqing is a southwest city of China with a large rural population. A retrospective observational study has been performed based on routi…
Zikria Saleem, Masaad Saeed Almutairi, Huda Arooj, Faris S Alnezary
**INTRODUCTION:** The interaction between human immunodeficiency virus (HIV) and tuberculosis (TB) presents a persistent public health challenge, particularly with the emergence of multidrug-resistant TB (MDR-TB) and extensively drug-resistant TB (XDR-TB). The Middle East and Nor…
Zhang SX, Wang JC, Yang J, Lv S, Duan L, et al.
Background The co-infection of human immunodeficiency virus (HIV)/acquired immune deficiency syndrome (AIDS) and tuberculosis (TB) poses a significant clinical challenge and is a major global public health issue. This study aims to elucidate the disease burden of HIV-TB co-infect…
Diriba G, Alemu A, Yenew B, Tola HH, Gamtesa DF, et al.
Objectives To estimate the pooled proportion of extensively drug-resistant tuberculosis (XDR-TB) and pre-extensively drug-resistant tuberculosis (pre-XDR-TB) in patients with multidrug-resistant TB (MDR-TB). Methods We systematically searched articles from electronic databases: M…
Guo H, An J, Li S, Ding B, Zhang Z, et al.
Background In this study, we utilized whole genome sequencing (WGS) of clinical extremely drug-resistant tuberculosis (EDR-TB) strains collected during 2014-2020 in Beijing to detect clustered strains. Methods A retrospective cohort study was conducted by inclusion of EDR-TB pati…
Pargali RH, Salehi MB, Bahador N
Patients with cancer are vulnerable to infections caused by mycobacteria and Nocardia. Antimicrobial agents are necessary to treat these infections, but extensive antibiotic use can lead to drug-resistant strains. Due to this issue, in the present study, we aimed to isolate, mole…
Nehru VJ, Jose Vandakunnel M, Brammacharry U, Ramachandra V, Pradhabane G, et al.
Fluoroquinolone resistance is a major challenge in treating Multidrug-Resistant Tuberculosis globally. The GenoType MTBDRsl Ver 2.0, endorsed by the WHO, was used to characterize fluoroquinolone resistance. The fluoroquinolone resistance rates in the MDR-TB, Rifampicin-Resistant …
Olivera Bojovic, D. Gudelj, S. Lucic, Božidarka Rakočević
Background: In the conditions of declining rate of drug-resistant tuberculosis and high success rate of treatment of these cases, occurrence of MDR/XDR-TB due to complexity of its treatment remains the main problem in controlling this disease in Montenegro. Methods and materials:…
Elion Assiana DO, Abdul JBPA, Linguissi LSG, Epola M, Vouvoungui JC, et al.
Background There is paucity of data on the prevalence and distribution of multidrug- Resistant-Tuberculosis (MDR-TB) in the Republic of Congo. Among the challenges resides the implementation of a robust TB resistance diagnostic program using molecular tools. In resource limited s…
Ibrahim Khalil, Noshin Anjum Tasmi, Md Imran Hossain, Mst Mahmuda Akter
**BACKGROUND:** HIV/AIDS and multidrug-resistant tuberculosis (MDR-TB, non-extensively drug-resistant) together cause significant mortality in Africa, home to 67% of the 39 million people living with HIV globally and 2.5 million TB cases in 2022. This study analyzes Global Burden…
О. А. Пасечник, В. Л. Стасенко
The results of modeling the further development of the epidemic process of tuberculosis in several regions of the world, including the Russian Federation, indicate an unfavorable prognosis in the spread of multidrug-resistant and extensively drug-resistant Mycobacterium tuberculo…