Showing 26–50 of 200 documents
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Sanchini A, Lanni A, Giannoni F, Mustazzolu A
Despite available global efforts and funding, Tuberculosis (TB) continues to affect a considerable number of patients worldwide. Policy makers and stakeholders set clear goals to reduce TB incidence and mortality, but the emergence of multidrug-resistant TB (MDR-TB) and extensive…
Kozińska M, Bogucka K, Kędziora K, Szpak-Szpakowska J, Pędzierska-Olizarowicz W, et al.
Drug-resistant TB (DR-TB) in children is a special epidemiological, clinical, and diagnostic problem, and its global incidence remains unknown. DR-TB in children is usually of a primary nature and is most often transmitted to the child from a household contact, so these cases ref…
Yonas Ghebrekristos, Erick Auma, Zama Mahlobo, Rouxjeane Venter, Natalie Beylis, et al.
**UNLABELLED:** Mycobacterium Growth Indicator Tube (MGIT) 960 culture is critical for tuberculosis (TB) drug susceptibility testing (DST) but is vulnerable to contamination. We evaluated the accuracy of Xpert MTB/XDR, a molecular DST for isoniazid, fluoroquinolone, amikacin, and…
Yonas Ghebrekristos, Erick Auma, Zama Mahlobo, Rouxjeane Venter, Natalie Beylis, et al.
**INTRODUCTION:** Mycobacterium Growth Indicator Tube (MGIT) 960 culture is critical for tuberculosis (TB) drug susceptibility testing (DST) but vulnerable to contamination. We evaluated the accuracy of Xpert MTB/XDR, a molecular DST for isoniazid, fluoroquinolone, amikacin, and …
Sahak Mkrtchyan
Extrapulmonary tuberculosis (TB), particularly when it involves the central nervous system (CNS), remains a significant clinical challenge. Cerebral tuberculoma, though rare, can present with complex symptoms that overlap with other neurological conditions, making timely diagnosi…
Mpagama SG
Background Tanzania is one of the countries confronting a multidrug-resistant tuberculosis (MDR-TB) epidemic. Research Research studies on drug susceptibility testing (DST) for second-line TB drugs given to Tanzanian MDR-TB patients has demonstrated mycobacterial resistance to im…
Muhammad Saleem, Syed Muhammad Ishaque, Muhammad Shafee Khosa, Zia Ud Din, Nargis Haider Kakar, et al.
Introduction: Mycobacterium tuberculosis (MTB) appears resistant to first line antibiotics e.g. rifampicin and isoniazid is said to be Multi-drug resistant Tuberculosis(MDR-TB), Globally 15.3 million cases emerge where as in Pakistan 1.8 million cases reported included Pakistan i…
Yuldashev S, Parpieva N, Alimov S, Turaev L, Safaev K, et al.
Uzbekistan has a large burden of drug-resistant tuberculosis (TB). To deal with this public health threat, the National TB Program introduced rapid molecular diagnostic tests such as Xpert MTB/RIF (Xpert) and line probe assays (LPAs) for first-line and second-line drugs. We docum…
Chiang TY, Fan SY, Jou R
Timely diagnosis of drug-resistant tuberculosis (DR-TB) is beneficial for case treatment and management. We implemented an algorithm to improve molecular diagnostic utilization to intensify DR-TB case findings. The GeneXpert MTB/RIF (Xpert) test was used for initial diagnosis. Sa…
Zafran Khan, Daniya Ualiyeva, Khalid Jamal, Babar Ali, Fayaz Ahmad, et al.
Mycobacterium tuberculosis (Mtb) is a causative agent of the infectious disease tuberculosis (TB), which has hampered susceptible populations in modern-day societies for years. Additionally, the emergence of multidrug-resistant (MDR) and extensively drug-resistant (XDR) Mtb strai…
Lindiwe Modest Faye, Carine Bokop, Sandeep Vasaikar, Teke Apalata, Ntandazo Dlatu
Infectious illnesses have always posed a threat to human health, with tuberculosis (TB) being a major concern. The use of various medications and antibiotics in the fight against such illnesses has led to the emergence of drug-resistant infectious diseases, which have become incr…
Muthukrishnan L
…eviewed. A decade long state-of-the-art knowledge on TB nanodiagnostics, fabrication concepts and performance characteristics has been reviewed.
Satyavratan Govindarajan, S. R. Manuskandan, Ramakrishnan Swaminathan
…tes the MDR-TB condition using CXR images, its computerized diagnostics could be used in the early screening and followup of TB ridden patients for public health infection control in any setting.
Andrea Sanchini, Alessio Lanni, Federico Giannoni, Alessandro Mustazzolu
Despite available global efforts and funding, Tuberculosis (TB) continues to affect a considerable number of patients worldwide. Policy makers and stakeholders set clear goals to reduce TB incidence and mortality, but the emergence of multidrug-resistant TB (MDR-TB) and extensive…
Antonino Catanzaro, MD
The goal of this study is to evaluate time to diagnosis for three assays (line probe, pyrosequencing, and Microscopic Observation Drug Susceptibility Assay \[MODS\]) to detect resistance to first and second-line anti-tuberculosis (TB) drugs in Mycobacterium tuberculosis (Mtb) str…
Kurt Wollenberg, Michael A. Harris, Andrei Gabrielian, Nelly Ciobanu, Dumitru Chesov, et al.
Abstract Background Recurrence of drug-resistant tuberculosis (DR-TB) after treatment occurs through relapse of the initial infection or reinfection by a new drug-resistant strain. Outbreaks of DR-TB in high burden regions present unique challenges in determining recurrence statu…
Faeez Muhammad, Laiba Siddiqui, Rabbia Gul
Tuberculosis (TB) is one of the leading infectious diseases that is highly transmissible. It is reported to cause approximately 10 million infections and 1.4 million deaths globally in the year of 2019.¹ Prompt detection and treatment of TB are essential to intercept the prolifer…
John Metcalfe, Peter Bacchetti, Aliasgar Esmail, Andrew Reckers, David Aguilar, et al.
Abstract Background Treatment monitoring of drug-resistant tuberculosis (DR-TB) in resource-limited settings is challenging. We developed a multi-analyte assay for eleven anti-TB drugs in small hair samples as an objective metric of drug exposure. Methods Small hair samples were …
Michael L. Chen
The diagnosis of multidrug resistant and extensively drug resistant tuberculosis is a global health priority. Whole genome sequencing of clinical Mycobacterium tuberculosis isolates promises to circumvent the long wait times and limited scope of conventional phenotypic antimicrob…
Girija Shankar Udgata, Srikanta Dash -
Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis (MTB), one of the top 10 causes of death worldwide (ranking above HIV/AIDS). About a quarter of the world's population is infected with TB and thus at risk of developing TB disease. The Global TB Repo…
Metcalfe J, Bacchetti P, Esmail A, Reckers A, Aguilar D, et al.
Background Treatment monitoring of drug-resistant tuberculosis (DR-TB) in resource-limited settings is challenging. We developed a multi-analyte assay for eleven anti-TB drugs in small hair samples as an objective metric of drug exposure. Methods Small hair samples were collected…
Ameya D. Bendre, Pooja Singh, Swati Jaiswal
…developing new drugs and treatments, advancing vaccines and diagnostics, exploring innovative approaches for multidrug- and extensively drug-resistant TB, and investigating the molecular and genetic factors that influence mycobacterial responses to therapy, all to improve TB diag…
Ambreen Shaikh, Camilla Rodrigues
…. Nucleic Acid Amplification Tests Advances in molecular TB diagnostics over the last decade have resulted in emerging technologies for TB testing that are both accurate and fast. Molecular tests are also used to detect resistant target gene mutations. Low-complexity tests such a…
Foundation for Innovative New Diagnostics, Switzerland
…ver, the inherent design of probe- or array-based molecular diagnostics limits their coverage to a limited number of specific mutations included in the initial design-locked assay, and prevents them from integrating new mutations and new drug resistance prediction without going b…
Simon Tiberi, Giovanni Battista Migliori, Jeremiah Chakaya, Tereza Kaesava, Seif Al-Abri, et al.
…g up to date on the latest developments of TB epidemiology, diagnostics, treatment regimens is vital for continuing medical education (CME) and continuing professional development (CPD). For achieve this, update courses with the latest developments are important, especially. The …