Showing 26–50 of 200 documents
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Zhang L, Li Y, Zou X, Ma H, Gao M, et al.
Objective This study aims to evaluate the diagnostic accuracy of a Mycobacterium tuberculosis (MTB)-specific triple-color FluoroSpot assay (IFN-γ/IL-2/TNF-α) in the differentiation of tuberculosis (TB) infection status in febrile patients. Method Febrile patients with suspected a…
Luo D, Yang BY, Qin K, Shi CY, Wei NS, et al.
Purpose Distinguishing latent tuberculosis infection (LTBI) from active tuberculosis (ATB) is important to control the prevalence of tuberculosis; however, there is currently no effective method. The aim of this study was to discover specific metabolites through fecal untargeted …
Yinghui Fu, Xue Yang, Hongyan Chen, Yugang Lu
Abstract Tuberculosis (TB) induced by Mycobacterium tuberculosis (Mtb) is a serious global health burden. This study sought to investigate the expression and diagnostic value of serum miR-145 in TB patients and explore the biological function of miR-145 using macrophages. Serum e…
Iqhrammullah M, Yusnaini R, Amirah S, Mulya IC, Tsurayya G, et al.
Background Identifying active tuberculosis (ATB) from latent tuberculosis infection (LTBI) persists as a challenge, and interferon-γ inducible protein-10 (IP-10) has been employed as the solution. To further improve its diagnostic performance, the sample can be stimulated with TB…
Zikun Huang, Cuifen Xiong, Qing Luo, Juxiang Zhu, Yongqin Guo, et al.
Despite efforts to control it, tuberculosis (TB) remains a significant challenge in the field of public health globally.1 Timely diagnosis of active TB is essential to control disease transmission.2 A recently discovered group of small non-coding RNAs, namely transfer RNA-derived…
Krutikov M, Faust L, Nikolayevskyy V, Hamada Y, Gupta RK, et al.
…form implementation in key populations. Funding StopTB (New Diagnostics Working Group) and FIND. Translations For the Chinese and Russian translations of the abstract see Supplementary Materials section.
Linsheng Li, Zhuang Li, Ling Yang, Zhaoyang Ye, Ruizi Ni, et al.
Abstract Background Latent tuberculosis infection (LTBI) is a significant source of active tuberculosis (ATB), yet distinguishing between them is challenging because specific biomarkers are lacking. Methods We analyzed four microarray datasets (GSE19491, GSE37250, GSE54992, GSE28…
Mahmoudi S, Hosseini Sharif SMS
Introduction Tuberculosis (TB) remains a global health challenge, underscoring the need for accurate diagnosis, particularly for Latent TB Infection. This meta-analysis assesses the diagnostic performance of QuantiFERON-TB Gold Plus (QFT) using Enzyme-Linked Immunosorbent Assay (…
Fu Y, Yang X, Chen H, Lu Y
Tuberculosis (TB) induced by Mycobacterium tuberculosis (Mtb) is a serious global health burden. This study sought to investigate the expression and diagnostic value of serum miR-145 in TB patients and explore the biological function of miR-145 using macrophages. Serum expression…
López-Suárez A, Santos-Sebastián M, Hernanz-Lobo A, Rincón-López E, Aguilera-Alonso D, et al.
Introduction Immune-based diagnostic tests for tuberculosis (TB) have suboptimal sensitivity in children and cannot differentiate between latent infection (LTBI) and active disease. This study evaluated the diagnostic potential of a broad range of biomarkers of tissue damage and …
Liu H, Dass SA, Wong MTJ, Balakrishnan V, Nordin F, et al.
…othesize the possible utility of the said antibody for both diagnostics and therapeutics of latent tuberculosis after more investigations with clinical samples.
Krista Meserve, Cole A Chapman, Mingrui Xu, Haowen Zhou, Heather M Robison, et al.
…entially lead to further Mtb transmission. However, current diagnostics often lack specificity for LTBI and do not inform on TB reactivation risk. We hypothesized that immune profiling readily available QuantiFERON-TB Gold Plus (QFT) plasma supernatant samples could improve LTBI …
Chen H, Nakagawa A, Takamori M, Abe S, Ueno D, et al.
Purpose The diagnostic accuracy of the interferon-gamma release assay (IGRA) in immunosuppressed patients remains unclear. Methods A systematic review and meta-analysis were performed for diagnostic test accuracy of IGRA in tuberculosis (TB) infection among people living with HIV…
Ji X, Yao S, Jia H, Sun Q, Wang Y, et al.
Background The World Health Organization encourages the development of novel diagnostic tools based on 'non-sputum' samples to meet global goals for tuberculosis (TB) control. We aimed to develop a machine learning-driven model for TB diagnosis, using long non-coding RNAs (lncRNA…
Burel JG, Babor M, Pomaznoy M, Lindestam Arlehamn CS, Khan N, et al.
Tuberculosis (TB) is a major infectious disease worldwide, and is associated with several challenges for control and eradication. First, more accurate diagnostic tools that better represent the spectrum of infection states are required; in particular, identify the latent TB infec…
Анна Старшинова, E. V. Istomina, Yulia Zinchenko, Michail Filatov, С. Б. Ланда, et al.
The diagnostic of tuberculosis infection, including the use of immunological methods, evolved significant changes. The introduction of new diagnostic tests allowed to improve the diagnosis of latent tuberculosis infection (LTI). However, the positive results of immunological test…
Xiuxiu Ji, Siyu Yao, Hongyan Jia, Qi Sun, Yingchao Wang, et al.
**BACKGROUND:** The World Health Organization encourages the development of novel diagnostic tools based on 'non-sputum' samples to meet global goals for tuberculosis (TB) control. We aimed to develop a machine learning-driven model for TB diagnosis, using long non-coding RNAs (l…
Dr.Anmar Talib, Rafeef Y. Rashid Rashid
…ortant for extra pulmonary TB cases, although immunological diagnostics such as interferon-gamma release assays (IGRA) and T-spot methods that associated with the identification of latent TB infection. Although their routine use was still hindered by infrastructure and expense, e…
Robison HM, Escalante P, Valera E, Erskine CL, Auvil L, et al.
…cted ~10% will proceed to active tuberculosis (TB). Current diagnostics cannot definitively identify LTBI and provide no insight into reactivation risk, thereby defining an unmet diagnostic challenge of incredible global significance. We introduce a new machine-learning-driven ap…
Changchun Wu, Xueqin Xie, Ziru Huang, Yuwei Zhou, Yushu Gou, et al.
**BACKGROUND:** Accurate and rapid diagnosis is essential for controlling pulmonary tuberculosis (PTB) by enabling timely intervention and reducing disease transmission. Existing diagnostic methods for PTB are limited by sensitivity, specificity, or practicality. **RESULTS:** He…
Xiuxiu Ji, Siyu Yao, Hongyan Jia, Qi Sun, Yingchao Wang, et al.
BACKGROUND: The World Health Organization encourages the development of novel diagnostic tools based on 'non-sputum' samples to meet global goals for tuberculosis (TB) control. We aimed to develop a machine learning-driven model for TB diagnosis, using long non-coding RNAs (lncRN…
Luo Y, Xue Y, Liu W, Song H, Huang Y, et al.
Background The discrimination between active tuberculosis (ATB) and latent tuberculosis infection (LTBI) remains challenging. The present study aims to investigate the value of diagnostic models established by machine learning based on multiple laboratory data for distinguishing …
Sun Z, He B, Yang Z, Huang Y, Duan Z, et al.
Tuberculosis (TB) is a prevalent and severe infectious disease that poses a significant threat to human health. However, it is frequently disregarded as there are not enough quick and accurate ways to diagnose tuberculosis. Here, we develop a strategy for tuberculosis detection t…
Jeong JH, Shim SR, Han S, Hwang I, Ihm C
Background PCR and culture tests are used together to confirm the diagnosis of active tuberculosis (TB). Due to the long culture period, if the PCR test is negative, it takes a significant amount of time for the culture result to be available. Interferon- γ release assays (IGRAs)…
Bourlon C, Camacho-Hernández R, Fierro-Angulo OM, Acosta-Medina AA, Bourlon MT, et al.
Latent tuberculosis infection (LTBI) affects one-fourth of the world´s population. Hematopoietic stem cell transplantation (HSCT) recipients are at an elevated risk of developing active tuberculosis infection (ATBI). In this retrospective study of donors and HSCT recipients who u…