Showing 26–50 of 200 documents
Sorted by hybrid relevance (keyword + semantic via RRF)
Hazratullah Bariz, Muhammad Haroon Stanikzai, Ghulam Mohayuddin Mudaser, Khalid Ahmad Stanikzai, Omid Dadras
**BACKGROUND:** Diagnostic delay among tuberculosis (TB) patients leads to late anti-TB treatment initiation, which is associated with poor prognosis and increased TB transmission. Despite its recognized negative consequences, diagnostic delay among TB patients is common in devel…
Yadav S, Rawal G, Jeyaraman M, Jeyaraman N
…p and the hurdles encountered with traditional tuberculosis diagnostics. From there, it traces the journey of the Xpert MTB/RIF technology, underscoring its molecular underpinnings. In this narrative review, the performance of the Xpert MTB/RIF Ultra system undergoes thorough scr…
Anchu R Nath, Nayanabai Shabadi, И. М. Сон, P V Manirsha
…andardized diagnostic algorithms, and integrating molecular diagnostics are essential to improve patient care. A multidisciplinary and collaborative approach is recommended to overcome existing barriers.
Hongxia Yan, Hongfei Duan, Xiaoxu Han, Jin Sun, Qingtao Liang, et al.
**INTRODUCTION:** Diagnosing tuberculosis (TB) in HIV-infected individuals presents significant challenges due to difficulties in obtaining specimens containing adequate quantities of(). This study aimed to evaluate the diagnostic performance of themRNA assay independently and in…
Ria Winkelmann, Belana Blasczok, Melanie Winter, Peter Wild, Maria J G T Vehreschild, et al.
**INTRODUCTION:** Extrapulmonary tuberculosis (TB) and non-tuberculous mycobacterial (NTM) disease remain a diagnostic challenge and conventional methods such as mycobacterial culture or molecular methods (e.g. GeneXpert) performed on formalin-fixed paraffin embedded (FFPE) speci…
E. Yu. Nosova, M. A. Sviridenko, Anastasia Khakhalina, Ksenia Galkina, Yu. D. Mikhailova, et al.
…8 patients (including HIV-infected ones) requiring rapid TB diagnostics. The study was conducted from one portion of the sediment of the diagnostic sample using bacteriological methods (luminescent microscopy, cultivation on Middlebrook 7H9 medium in the Bactec MGIT 960 system an…
Luo Y, Xue Y, Lin Q, Mao L, Tang G, et al.
Background The differential diagnosis between tuberculous meningitis (TBM) and bacterial meningitis (BM) remains challenging in clinical practice. This study aimed to establish a diagnostic model that could accurately distinguish TBM from BM. Methods Patients with TBM or BM were …
He H, Zou Y, He J, Bu H, Liu Y
It is very difficult to diagnose and distinguish tuberculous meningitis, and the current laboratory methods are unsubstantial in developing countries. The study is aimed at creating a scoring system on the basis of basic laboratory and clinical achievements that could be used as …
Fuyong Liu, Zheng Li, Xuejiao Li, Wei Hong, Yanlin Zhou, et al.
**OBJECTIVE:** We developed and validated a diagnostic scoring system for tuberculous meningitis (TBM) using 13 laboratory parameters, comparing tuberculous meningitis (TBM) and non-tuberculous meningitis (non-TBM). **METHODS:** This study enrolled patients diagnosed with mening…
G McNally, D Solomon, M Brown, S Capocci, D Creer, et al.
…y score, using results of mycobacterial cultures, molecular diagnostics, microscopy, histology, clinical and radiology results, to grade cases on a 1-5 scale. Since 2017, this has been routinely used as part of our quarterly patient Cohort Reviews. We evaluated the relationship b…
Yang Y, Qu XH, Zhang KN, Wu XM, Wang XR, et al.
Background: The discrimination of tuberculous meningitis and bacterial meningitis remains difficult at present, even with the introduction of advanced diagnostic tools. This study aims to differentiate these two kinds of meningitis by using the rule of clinical and laboratory fea…
Upasana Das, Kalyani Prava Gauda, Indrani Mohanty, Atanu Kumar Bal, Sasmita Hotta
Introduction: Infection with tuberculosis is a worldwide health concern. Nearly every organ in the body can be affected by Extrapulmonary Tuberculosis (EPTB). A simple diagnosis of Pulmonary Tuberculosis (PTB) can be made using radiography and a positive sputum test. On the other…
Walzl G, McNerney R, du Plessis N, Bates M, McHugh TD, et al.
…nts and key achievements in the search for new tuberculosis diagnostics and biomarkers. We highlight gaps and challenges in evaluation and rollout of new diagnostics and biomarkers, and prioritise areas needing further investment, including impact assessment and cost-benefit stud…
Le HN, Sriplung H, Chongsuvivatwong V, Nguyen NV, Nguyen TH
Introduction Tuberculous meningitis (TBM) is the most dangerous form of tuberculosis with high mortality and disability rates. However, the delayed diagnostic process is often due to the absence of the gold standard tests leading to a lack of information about the sensitivity and…
Jose RA, Raja Inbaraj L, Catherine Vincent R, Baskar A, Mathew R
Background The diagnosis of Tuberculosis (TB) has been a challenge till the advent of rapid molecular diagnostic tests. The traditional diagnostic tests have its own limitations with regard to its performance or the turnaround time. Truenat MTB Plus assay, a battery-operated mole…
MBBS, MD, Navakumar Manickam
Cutaneous tuberculosis (CTB) is a rare form of extrapulmonary tuberculosis, accounting for less than 2% of all TB cases. Its atypical presentations, which deviate from the classical forms like lupus vulgaris and tuberculosis verrucosa cutis, pose significant diagnostic challenges…
Shani Abidi, Handri Andika
Background: Tuberculosis (TB) remains a major global health challenge, with its variable clinical presentations often complicating timely and accurate diagnosis. Diagnostic imaging modalities such as chest X-ray, computed tomography (CT), magnetic resonance imaging (MRI), and pos…
Jonas Wilmink, Richard Vollenberg, Ioana D Olaru, Julia Fischer, Jonel Trebicka, et al.
: Extrapulmonary tuberculosis accounts for a significant portion of tuberculosis cases, presenting unique diagnostic challenges due to its heterogeneous manifestations and paucibacillary nature. This study aims to fill this gap by evaluating the diagnostic outcomes and correlatio…
Zhan W, Wang T, Yang C, Wang Y, Wan N, et al.
Introduction Mediastinal and hilar lymphadenopathies are primarily diagnosed pathologically. Contact laser-assisted endobronchial ultrasound-guided tunnel drilling biopsy (EBUS-TDB), which uses a laser as a tunneling and incision tool, may yield more satisfactory specimens than c…
Dong THK, Donovan J, Ngoc NM, Thu DDA, Nghia HDT, et al.
Background Diagnosis of tuberculous meningitis (TBM) is hampered by the lack of a gold standard. Current microbiological tests lack sensitivity and clinical diagnostic approaches are subjective. We therefore built a diagnostic model that can be used before microbiological test re…
Prasad MK, Kumar A, Nalini N, Kumar P, Mishra B, et al.
Tuberculous meningitis is the most serious complication of tuberculosis. Early diagnosis is crucial to start relevant treatment to prevent death and disability. Electronic databases PubMed, Google Scholar, and Cochrane Library were used to find relevant articles from January 1980…
Niu M, Bai Z, Dong L, Zheng W, Wang X, et al.
Background and aim: Tuberculous meningitis (TBM) and cryptococcal meningitis (CM) are easily misdiagnosed due to atypical clinical symptoms. It is difficult for physcians to achieve a rapid and accurate differential diagnosis of TBM in the early stages of disease onset. The aim o…
Aditya Kumar Jha
…ar microscopy and culture have low sensitivity, so advanced diagnostics like PCR, histopathology, FNAC, and Xpert MTB/ RIF are needed. This study aimed to assess the clinical features and diagnostic accuracy of these methods in smear-negative cervical tuberculous lymphadenitis. M…
Shruthi M Shetty, Priyanka D Shivarama, Amrita N Shamanewadi, Renuka Venkatesh, Thanzeer Thajudeen Pattapally, et al.
**BACKGROUND:** The diagnosis of Extrapulmonary TB(EPTB) has always been a challenge for health care providers as it generally requires resource and greater clinical expertise. Timely detection and proper treatment of TB are the key elements of an effective TB control program. Ou…
Christine Tzelios, Ruvandhi R. Nathavitharana
…OHigh-priority target product profiles for new tuberculosis diagnostics: report of a consensus meeting. World Health Organization, Geneva2014Google Scholar Above this sensitivity threshold, the receiver operating characteristic curves did not differ significantly between the five…