Showing 26–50 of 65 documents
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Finlayson H, Lishman J, Palmer M
Purpose of review The current review identifies recent advances in the prevention, diagnosis, and treatment of childhood tuberculosis (TB) with a focus on the WHO's updated TB management guidelines released in 2022. Recent findings The COVID-19 pandemic negatively affected global…
Said B, Charlie L, Getachew E, Wanjiru CL, Abebe M, et al.
The lack of rapid, sensitive, and deployable tuberculosis diagnostic tools is hampering the early diagnosis of tuberculosis and early detection of treatment failures. The conventional sputum smear microscopy or Xpert MTB/RIF assay cannot distinguish between alive and dead bacilli…
Kakinda M, Tugumisirize D, Nyombi A, Mugisha M, Turyahabwe S, et al.
Background Uganda introduced Xpert® MTB/RIF assay into its TB diagnostic algorithm in January 2012. In July 2018, this assay was replaced with Xpert® MTB/RIF Ultra assay. We set out to compare the tests done and tuberculosis cases detected by Xpert® MTB/RIF and Xpert® MTB/RIF Ult…
Van Wyk SS, Nliwasa M, Seddon JA, Hoddinott G, Viljoen L, et al.
Background Transmission of drug-resistant tuberculosis (DR-TB) is ongoing. Finding individuals with DR-TB and initiating treatment as early as possible is important to improve patient clinical outcomes and to break the chain of transmission to control the pandemic. To our knowled…
Oriekot A, Sereke SG, Bongomin F, Bugeza S, Muyinda Z
Background Tuberculosis (TB) is one of the leading causes of death worldwide. Radiology has an important role in the diagnosis of both drug-sensitive (DS) and rifampicin-resistant (RR) pulmonary TB (PTB). This study aimed to compare the chest x-ray (CXR) patterns of microbiologic…
Nidoi J, Muttamba W, Walusimbi S, Imoko JF, Lochoro P, et al.
Background Tuberculosis (TB) is a major public health problem and at 48%, Karamoja in North-Eastern Uganda has the lowest treatment success rate nationally. Addressing the social determinants of TB is crucial to ending TB. This study sought to understand the extent and ways in wh…
Oladimeji O, Adepoju V, Anyiam FE, San JE, Odugbemi BA, et al.
Background The Lagos State Tuberculosis, Buruli Ulcer, and Leprosy Control Program (LSTBLCP) started engaging private hospitals under the Public-Private Mix (PPM) Program in 2008. The study aimed to evaluate the trend and predictors of successful Tuberculosis (TB) treatment outco…
van den Boom M, Bennani K, Sismanidis C, Gunneberg C, Khawaja L, et al.
…d treatment. Bacteriological confirmation using recommended diagnostics also requires further optimisation.
Gordhan BG, Peters JS, McIvor A, Machowski EE, Ealand C, et al.
…atory molecules may facilitate improvement of culture-based diagnostics for TB.
Le H, Nguyen N, Tran P, Hoa N, Hung N, et al.
Setting The tuberculous infection control strategy, FAST (Find cases Actively, Separate safely and Treat effectively), recommends prompt initiation of likely effective anti-tuberculosis treatment informed by Xpert ® MTB/RIF results . OBJECTIVE: To describe FAST implementation at …
Adepoju VA, Adelekan A, Etuk V, Onoh M, Olofinbiyi B
Introduction TB diagnosis and treatment practices among private providers not affiliated with the Nigeria National TB Program (NTP) have implications for TB control efforts. Studies evaluating these practices among non-NTP providers are scarce. We aimed to investigate TB diagnosi…
Chikovani I, Shengelia N, Marjanishvili N, Gabunia T, Khonelidze I, et al.
…Georgia National TB Programme (NTP). This paper presents TB diagnostics and treatment unit cost, their comparison with NTP tariffs and how the study findings informed TB financing policy. METHODS: Top-down (TD) and bottom-up (BU) mean unit costs for TB interventions by episode of…
Olanisun P Adewole, MD, Bolanle A Omotoso, MD
Tuberculosis (TB) is caused by mycobacterial organism. It is the leading infectious disease cause of death globally, with more than 10 million new cases and over 2 million deaths annually. Developing countries bear the greatest brunt of the disease. The long duration of current t…
Jennifer Cohn, MD, Martina Casenghi, PhD
… care and strengthening access to WHO-recommended drugs and diagnostics. Integration refers to supporting TB activities, such as screening and TB sample collection for children, into non-TB health care services, such as general pediatric outpatient clinics. Decentralization refer…
Njoku Oluomachi Leticia, Iyanda Ayobola Abolape
Objective: This study investigates the interplay between specific trace elements particularly —zinc (Zn), copper (Cu), iron (Fe), and selenium (Se)—in newly diagnosed drug-sensitive tuberculosis (DSTB) and drug-resistant tuberculosis (DRTB) patients compared to a control group wi…
Tran Duong Thai, Nut Nithimongkolchai, Benjawan Kaewseekhao, Janejira Samarnjit, Chutipapa Sukkasem, et al.
Mycobacterium abscessus (M. abscessus) infection is a significant public-health concern due to its resistance to multiple antibiotics and associated treatment challenges. There is a pressing need for a rapid and effective method capable of reliably identifying M. abscessus drug r…
Anil S, Satish Ghatage, Kiran K, Shubha Davalgi, Swathi S Aithal, et al.
**BACKGROUND:** Tuberculosis (TB) remains a major global health condition, particularly in low- and middle-income countries. Treatment failure and relapse are of great concern, and treatment monitoring is largely dependent on smear microscopy. Smear microscopy has its limitations…
Hayoung Choi, Kyuna Lee, Kyungdo Han, Dong Wook Shin, Hyun Lee
**OBJECTIVES:** To evaluate the risk of incident non-tuberculous mycobacterial pulmonary disease (NTM-PD) following pulmonary tuberculosis (TB) in a nationwide longitudinal Korean cohort. **METHODS:** Using data from the Korean National Health Insurance Service and the Korean Di…
Saadick Mugerwa Ssentongo, Bonniface Oryokot, Ronald Opito, Gerald Ochieng, Peter Sekiranda, et al.
**BACKGROUND:** Uganda is among the 30 high tuberculosis (TB) burden countries, and still grapples with a suboptimal treatment success rate (the sum of cured and treatment completion), which stands at 89.1% for people living with HIV and 91.2% for those without HIV. The Teso regi…
Felix Bongomin, Martha Namusobya, Ritah Nantale, Daniel S Ebbs, Charles Batte, et al.
…long-term follow-up, respiratory rehabilitation, and fungal diagnostics into post-TB care pathways is essential to improve outcomes and reduce preventable mortality.
Saadick Mugerwa Ssentongo, Kenneth Kwenya, Bonniface Oryokot, Ronald Opito, Susan Alwedo, et al.
**BACKGROUND:** Tuberculosis (TB) remains a global public health burden, with 500,000 people dying of Tb in 2021. People living with HIV have an 18 times higher risk of having TB, which is associated with poor treatment outcomes. This study aimed to determine the treatment succes…
Zhen Feng, Hailan Wu, Qian Li, Xiaoqiang Zhang, Qingfeng He, et al.
**OBJECTIVES:** High-dose rifamycin (HDR) regimens have demonstrated significant potential in tuberculosis (TB) treatment. This study aims to evaluate the efficacy and safety profile of different HDR regimens. **DESIGN:** Using a systematic review and Bayesian network meta-analy…
Elias Jabbour, Marcia Pinto, Ricardo E Steffen, Fernanda Dockhorn, Daniele M Pelissari, et al.
**INTRODUCTION:** To eliminate tuberculosis (TB) in Brazil, scaling up screening and prevention strategies will be essential. We estimated costs of TB services in Brazil to support budgeting, cost-effectiveness analysis and inform the implementation of these strategies. **METHOD…
Muhammed S Bah, Kyaw Ko Ko Htet, Gregory P Bisson, Celso Khosa, Refiloe Masekela, et al.
Tuberculosis (TB) remains a major public health issue across the world and national TB guidelines are an important resource for diagnosis and treatment. This scoping review aimed to analyze how countries with the highest TB burdens approach the integration of comorbidity and risk…
Churako H, Tesema M, Tema L, Ababiya T, Wodajo D, et al.
Millions of individuals worldwide are afflicted by the fatal infectious disease tuberculosis, which accounts for thousands of avoidable deaths. The literature has provided a good description of the clinical manifestation and radiologic features of pulmonary tuberculosis. However,…