Showing 26–50 of 192 documents
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Padmapriydarsini C, Mamulwar M, Mohan A, Shanmugam P, Gomathy NS, et al.
…monary tuberculosis (PTB). Methods In a randomized, 8-week, clinical trial, newly diagnosed, culture-positive PTB patients were randomized to standard ATT (HREZ = control arm) or standard ATT plus daily 1000 mg metformin (MET-HREZ = Metformin with Rifampicin [METRIF] arm) for 8 w…
Kohei Fujita, Naoki Fujimoto, Saiki Yoshimura, Shogo Toyama, Takanori Ito, et al.
…t common adverse events (13.8%), followed by fever (10.3%). Clinical trial registration: This retrospective study was registered in the UMIN Clinical Trials Registry (registration No. UMIN000055755). This clinical trial was registered on 6 October 2024 and is publicly available.
Mathebula L, Mapahla L, Nurkhametova D, Ziganshina LE, Mazinu M, et al.
… to identify and describe ongoing, planned and completed TB trials conducted in the BRICS countries registered in WHO-International Clinical Trial Registry Platform (WHO-ICTRP); to report selective outcome reporting by comparing primary outcomes in published trials with their pre…
Martinson NA, Nonyane BAS, Genade LP, Berhanu RH, Naidoo P, et al.
… morbidity and mortality. We conducted a cluster-randomized trial of large urban and rural primary healthcare clinics in 3 provinces of South Africa to evaluate whether a novel intervention of targeted universal testing for TB (TUTT) in high-risk groups diagnosed more patients wi…
Zeguang Zheng, Wuzhuang Sun, Jieying Hu, Zhijun Jie, Jin‐Fu Xu, et al.
…ODS: This prospective, randomized, double-blind, controlled clinical trial in 10 centres enrolled patient with AECOPD and a Breathlessness, Cough, and Sputum Scale (BCSS) score of at least 6 points. Eligible patients were randomly assigned (in a 1:1 ratio) to receive either hydro…
Kang NM, Zhang N, Luo BJ, Wu ED, Shi JQ, et al.
…ntilator-associated adverse events. Registration number for clinical trial Chinese Clinical Trial Registry ChiCTR2000032311, April 21st, 2020.
Burza S, Mahajan R, Kazmi S, Alexander N, Kumar D, et al.
…ods This is a randomized, open-label, parallel-arm, phase 3 trial conducted within a single hospital in Patna, India. One hundred and fifty patients aged ≥18 years with serologically confirmed HIV and parasitologically confirmed VL were randomly allocated to 1 of 2 treatment arms…
Wang Chung Kwok, Shung Kay Samuel Chan, Ka Yan Chiang, Jcm Ho
…ECOPD. Methods This is a double‐blind randomized controlled trial. Patients will be randomized in 1:1 ratio to receive oral NAC at 600 mg twice daily or placebo twice daily with standard of care. Partial pressure of oxygen (PaO 2 ), partial pressure of carbon dioxide (PaCO 2 ) an…
Rongrong Kang, Huanqing Liu, Qian Lei, Tingting Li
…aditional statistical models struggle with high-dimensional clinical data, necessitating advanced machine learning (ML) approaches. **OBJECTIVE:** To analyze clinical data from 467 pulmonary TB patients and construct a predictive model using multiple ML algorithms. **METHODS:**…
Xiong L, Chen L, Wang C, Yue J, Li Y, et al.
…d safety, the authors systematically evaluated all relevant trials. Methods The authors searched published trials using the search strategy as (Tanreqing OR "Tanreqing injection") AND ("Tuberculosis" [MeSH] OR Tuberculosis OR TB) in Embase, PubMed, CNKI, VIP, Wanfang Database, CB…
Sahile Z, Perimal-Lewis L, Arbon P, Maeder AJ
…ystematically with evidence-based theory and conducting the trial with strong measurement methods. Methods This study is a single-blind parallel-group design individual randomized control trial. A total of 186 participants (93 per group) will be individually randomized into one o…
Pichanon Mingchay, Kamon Kawkitinarong, Pattama Torvorapanit, Pirapon June Ohata, Gompol Suwanpimolkul
… for presumed PTB. **METHODS:** In a randomized controlled trial at King Chulalongkorn Memorial Hospital, Thailand, 204 adults with presumed PTB and negative Xpert MTB/RIF Ultra results or inadequate sputum production were enrolled between July and October 2024. Participants wer…
Kazakova A, Zhelnov P, Sidorov R, Rogova A, Vasileva O, et al.
…prehensively identify and provide an overview of in vivo or clinical studies of nucleic acids (NA)-based vaccines against TB we included human or animal studies of NA vaccines for the prevention or treatment of TB and excluded in vitro or in silico research, studies of microorgan…
Fairall L, Petersen I, Zani B, Folb N, Georgeu-Pepper D, et al.
… Nations Programme on HIV/AIDS (UNAIDS) targets. The CobALT trial aims to provide evidence on the effectiveness and cost-effectiveness of scalable interventions to reduce the treatment gap posed by the growing burden of depression among adults on lifelong ART. Methods The study d…
Аlbert R. Muslimov, Pavel Zhelnov
…erculosis based on nucleic acids in development, both in preclinical and clinical studies, if any, and to provide an overview of their formulations of choice.METHODSEligibility criteria: Records will be eligible for inclusion if they report any (in vitro, in silico, or in vivo) d…
Xu Z, Chen W, Li X
… life of patients with pulmonary tuberculosis, with obvious clinical efficacy. Trial registration Chinese Clinical Trial Registry ChiCTR2100048983.
Ohno S, Umebayashi I, Matsukawa M, Goto T, Yano T
…er, the long-term safety profile and efficacy in real-world clinical settings in patients with RUBD have not been fully clarified. The BRIGHT study, a prospective, large-scale, long-term postmarketing surveillance (PMS) study, was conducted to investigate the long-term safety and…
Hayley A. Scott, Lisa G. Wood, Evan J. Williams, Natasha Weaver, John W. Upham
…cipants (75% female; mean age, 33.4 [9.9] yr) completed the trial. Moderate exercise induced a significant reduction in sputum eosinophil count (−173 [−337 to −10]; P = 0.032) and sputum percentage eosinophils (−2.2 [−4.9 to 0.5]; P = 0.049) relative to control. Vigorous exercise…
Moosa MS, Maartens G, Gunter H, Allie S, Chughlay MF, et al.
…We conducted a randomized, double-blind, placebo-controlled trial to assess the efficacy of intravenous NAC in hospitalized adult patients with anti-tuberculosis drug-induced liver injury (AT-DILI). The primary endpoint was time for serum alanine aminotransferase (ALT) to fall be…
Babalwa Zani, Lara Fairall, Inge Petersen, Naomi Folb, Arvin Bhana, et al.
…s a secondary analysis of data from a randomised controlled trial of depression management in 2002 adults receiving ART. We investigated the effects of sociodemographic characteristics, comorbidities, depression symptoms (Patient Health Questionnaire-9 (PHQ-9)), functional disabi…
Babalwa Zani, Lara Fairall, Inge Petersen, Naomi Folb, Arvin Bhana, et al.
…s a secondary analysis of data from a randomised controlled trial of depression management in 2002 adults receiving ART. We investigated the effects of sociodemographic characteristics, comorbidities, depression symptoms (Patient Health Questionnaire-9 (PHQ-9)), functional disabi…
Baluku JB, Ronald O, Bagasha P, Okello E, Bongomin F
…Web of Science, the Cochrane Central Register of Controlled Trials, mRCTs, Clinical trials.gov, and International Clinical Trials Registry Platform from inception to 31st December 2021. Among 110 eligible studies, 79 (238,316 participants) were included in the meta-analysis for s…
Zeguang Zheng, Kai Yang, Geoffrey Liu, Xiuhua Fu, Huijie He, et al.
…nter, randomized, double-blind, placebo-controlled, phase 3 trial at 19 centers in China. Hospitalized adult patients with mucopurulent sputum and expectoration difficulty were recruited. Patients were randomized by 1:1 to receive inhalation of either ambroxol hydrochloride solut…
William J Burman, M Florencia Martins, David Flynn, James Johnston, Pranay Sinha, et al.
…atment completion but have not been the focus of late-phase clinical trials. We performed a scoping review to identify interventions to improve the safety and tolerability of rifampin-susceptible tuberculosis. Our objective was to determine what interventions have been evaluated …
Shi W, Hu Y, Zheng X, Ning Z, Wu M, et al.
…n alterations in gut microbiota composition and unfavorable clinical outcomes. Methods The study is a multicenter, observational prospective cohort study. Three study sites are purposively selected in the western (Sichuan Province) and eastern (Jiangsu Province and Shanghai) part…