Showing 26–50 of 200 documents
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Irina V. Lyadova, A. A. Starikov
The spread of the novel coronavirus infection (COVID-19) makes the search for new approaches to prevent the infection of great importance. As one of the relevant approaches, the vaccination of risk groups with BCG vaccine has recently been suggested. BCG (Mycobacterium bovis, Bac…
Wenping Gong, Ashok Aspatwar, Jianping Xie, Hao Li
…f reduced bacterial burden in primates.• Argued that future vaccines must be designed to elicit a precisely tuned humoral immune response. • Corrected errors in the labeling of figures in the supplementary materials.• Confirmed that the corrections do not affect any experimental …
Wilson L, Gracie L, Kidy F, Thomas GN, Nirantharakumar K, et al.
Background Tuberculosis (TB) remains a leading cause of death worldwide, with 98% of cases occurring in low- and middle-income countries (LMICs). The only vaccine licenced for the prevention of TB has limited protection for adolescents, adults and vulnerable populations. A safe a…
Whitlow E, Mustafa AS, Hanif SNM
…aches, e.g., whole-cell organisms, subunit, and recombinant vaccines are currently being explored for safer and more efficacious TB vaccines than BCG. These approaches have been successful in developing a large number of vaccine candidates included in the TB vaccine pipeline and …
Chacon, Alexis
…not recommended for PLWH. Thus, the development of novel TB vaccines, which are safe and effective in PLWH, remains an urgent global necessity. We have found that humanized mice (hu-mice) are ideal models to research this as they can be successfully infected with HIV, TB and HIV/…
Kashangura R, Jullien S, Garner P, Johnson S
Background Tuberculosis causes more deaths than any other infectious disease globally. Bacillus Calmette-Guérin (BCG) is the only available vaccine, but protection is incomplete and variable. The modified Vaccinia Ankara virus expressing antigen 85A (MVA85A) is a viral vector vac…
Kumari R S, Sethi G, Krishna R
The etiological agent of tuberculosis (TB), Mycobacterium tuberculosis , is a deadly pathogen that adapts to thrive within the host. Since 2020, the COVID-19 pandemic has had colossal health, societal, and economic consequences, which have affected the reporting of new incidences…
Maurya SK, Aqdas M, Das DK, Singh S, Nadeem S, et al.
Background Approximately 80% - 90% of individuals infected with latent Mycobacterium tuberculosis (Mtb) remain protected throughout their life-span. The release of unique, latent-phase antigens are known to have a protective role in the immune response against Mtb. Although the B…
Katelaris AL, Jackson C, Southern J, Gupta RK, Drobniewski F, et al.
Background BCG appears to reduce acquisition of Mycobacterium tuberculosis infection in children, measured using interferon-gamma release assays (IGRAs). We explored whether BCG vaccination continues to be associated with decreased prevalence of M. tuberculosis infection in adult…
Yousefi Avarvand A, Khademi F, Tafaghodi M, Ahmadipour Z, Moradi B, et al.
…fections in adults. Furthermore, recently developed subunit vaccines, which are in various stages of clinical trials, are all prophylactic vaccines based on proteins expressed in replicating stage of M. tuberculosis and they are not preventive of reactivation of latent TB infecti…
Rahali N, Bahloul C
… vaccination can help against immune escapes of the current vaccines.
Tovar M, Moreno Y, Sanz J
… clinical trial outcomes, unlocking impact forecasting from vaccines whose specific mechanisms of action are unknown. Applying our method to the analysis of the M72/AS01 E vaccine trial -conducted on IGRA+ individuals- as a case study, we found that most plausible models for this…
Chen NY, Liu ZH, Kao SW, Lin HS, Lee IK, et al.
…ID-19 vaccination, it has remained unclear whether COVID-19 vaccines interfere with IGRA readouts. Methods We prospectively recruited healthcare workers during their annual occupational health examinations in 2021. Baseline IGRA readouts were compared with follow-up data after th…
Lew MH, Norazmi MN, Nordin F, Tye GJ
…ctor determining the safety and efficacy of newly developed vaccines against Mycobacterium tuberculosis infection. Crosstalk between CD4 + and CD8 + T-lymphocytes plays central roles in perpetuating the cytotoxic killing to the infected cells for host clearance. Our study propose…
E Freire Rodrigues, Andreia Leite, M Cabral, G Duarte, Ana Paula Lerner Marques, et al.
Abstract Issue Tuberculosis (TB) incidence in Portugal is < 20/100000 people, with high-incidence municipalities in urban areas such as Amadora. In 2016, the national vaccination programme moved the BCG vaccine from universal to restricted risk groups. Amadora, due to the …
Л. Н. Мотанова, M. N. Kudrya
Introduction . BCG vaccination is included in the vaccination schedules of many countries. Numerous studies show its high efficacy, especially in regions with a high prevalence of the disease, and the limited efficacy of revaccination. The objective of the study : to estimate the…
Strong EJ, West NP
…l membrane protein Large (MmpL) family as potential subunit vaccines for TB. MmpLs are large, multifunctional integral membrane proteins, and as such are recalcitrant to purification. Here, we describe a strategy of producing synthetic antigens comprised of the soluble, extracell…
Angelique Luabeya, MD
This is a Phase I, open-label, dose-escalation study with three study groups. This study will be conducted in 25 HIV negative subjects, 17 of whom will have Latent Tuberculosis Infection (LTBI) and 8 of whom will not have LTBI at study enrollment. The investigational product is A…
Weng S, Zhang J, Ma H, Zhou J, Jia L, et al.
…expression profiles differ at different growth periods, and vaccines protective and therapeutic effects may increase when they include antigenic compositions from different periods. To develop a post-exposure vaccine that targets LTBI, we constructed four therapeutic DNA vaccines…
Runyo F, Matignon M, Audureau E, Vindrios W, Boueilh A, et al.
…erculosis infection (LTBI), and updating of the recommended vaccines. We prospectively evaluated in dedicated infectious diseases consultations, from 2014 to 2018, the clinical and vaccination data of new adult kidney allograft candidates. Patients were offered an updated vaccina…
Koff A, Inaty H
SARS-CoV-2 mRNA vaccines are safe and effective for the prevention of COVID-19 infection, though local reactions are commonly reported. Axillary lymphadenopathy has also been reported, which has the potential of causing diagnostic confusion and unnecessary testing and procedures.…
Flores-Valdez MA, Pedroza-Roldán C, Aceves-Sánchez MJ, Peterson EJR, Baliga NS, et al.
Mycobacterium tuberculosis ( M. tuberculosis ), the causative agent of human tuberculosis (TB), is estimated to be harbored by up to 2 billion people in a latent TB infection (LTBI) state. The only TB vaccine approved for use in humans, BCG, does not confer protection against est…
Elaheh Abdollahi, Seyed M Moghadas, Alison P Galvani
…s initiative, including the potential use of therapeutic TB vaccines that are currently undergoing clinical trials. **METHODS:** We developed an agent-based model of TB transmission dynamics that includes the demographic distributions and household structure of the Nunavut popul…
Ian Toma, MD, PhD
Maternal infections affect the basal immune status of neonates. One of the possible mechanism is the fetomaternal microchimerism, in which some cells and active substances are exchanged bi-directionally between maternal and fetal circulation through placenta. Even in the absence …
Xiaofang Zhao, Caihong Guo, Lianwen Wang, Zhijun Liu
…TB in adults varies significantly. Currently, six candidate vaccines aimed at preventing or delaying the progression from LTBI to active TB have advanced to Phase III clinical trials, among which the novel M72/AS01E candidate vaccine elicits a sustained immunogenicity with a prot…