Showing 26–50 of 200 documents
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Naoto Kuroda
…tizens is necessary. If infants in Japan do not receive BCG vaccines, tuberculosis might spread. We must prevent this from happening by publicizing inadequate evidence of causality between the BCG and prevention of the COVID-19. We also need to highlight the concern that a shorta…
Lee S, Kim T, Seong KY, Yim SG, Lee WK, et al.
…r 8 weeks at -20 °C. In vivo vaccination tests using BCG-MN vaccines on guinea pigs exhibited no adverse reactions. Moreover, the BCG-MN vaccine demonstrated superior immune response compared to injections, suggesting that this BCG vaccine-coated MN platform has the potential as …
Machlaurin A, Pol SV, Setiawan D, van der Werf TS, Postma MJ
…s effectiveness is limited and varies by age. New candidate vaccines are currently being investigated. In response to the declining incidence of TB, practices relating to BCG vaccination have changed in various countries in recent years. A valid cost-effectiveness study is theref…
Penn-Nicholson A, Tameris M, Smit E, Day TA, Musvosvi M, et al.
Background A vaccine that prevents pulmonary tuberculosis in adults is needed to halt transmission in endemic regions. This trial aimed to assess the safety and immunogenicity of three administrations at varying doses of antigen and adjuvant of an investigational vaccine (ID93 + …
Valizadeh A, Khosravi A, Sedighian H, Behzadi E, Gholami Parizad E, et al.
Background & objective Despite the vaccination with the BCG vaccine, tuberculosis (TB) remains one of the major health problems in the world. The aim of this study was to evaluate our newly designed vaccine using IL-22 as an adjuvant in comparison with the common BCG vaccine. Met…
Augustinas Stasiūnas, Jurgita Stasiūnienė, Enrika Didžiulienė
…-rapid seroconversion. Understanding this BCG and influenza vaccines interaction is crucial for healthcare providers to differentiate between benign post-vaccination reactions and those that may require further clinical evaluation.
Hope JC, Khalid H, Thom ML, Howard CJ, Shaw DJ
Mycobacterium bovis , the causative agent of bovine tuberculosis (bTB), is a globally prevalent pathogen with significant animal welfare, economic and public health impacts. In the UK, the control of bTB relies on detection via tuberculin skin tests with ancillary interferon gamm…
Yu Hwa Choi
The purpose of this study is to evaluate safety, immunogenicity of ID93+GLA-SE compared to placebo following three intramuscular (IM) injections on Days 0, 28 and 56 in BCG-vaccinated QFT-negative healthy adolescent. The healthy adolescent will all have had the childhood TB vacci…
Bassoum O, Sougou NM, Ba MF, Anne M, Bocoum M, et al.
Background In Senegal, studies focusing specifically on vaccination coverage with the Bacille de Calmette et Guérin (BCG) vaccine, the birth dose of oral polio vaccine (OPV zero dose) and the birth dose of hepatitis B (HepB-BD) vaccine are insufficient. This study aimed to highli…
Yu Hwa Choi
The purpose of this study is to evaluate the experimental tuberculosis (TB) vaccine called ID93+GLA-SE. The safety, immunogenicity, and efficacy of ID93+GLA-SE will be compared to placebo, after three intramuscular (IM) injections one month apart in healthy healthcare workers. Th…
Azar Najafi, Nahid Mahdian, Bahman Yousefi, Mohsen Karbalaei, Ali Kermanjani, et al.
…d in vivo examinations, such as recombinant BCG (rBCG), DNA vaccines, and subunit vaccines. Factors, such as applicability of vaccine candidates in all individuals, cost-effectiveness, long-term immunity and stimulation of a wide range of responses are important factors. Now, mos…
Hu Z, Jiang W, Gu L, Qiao D, Shu T, et al.
…e antigen-specific T cell responses induced by the separate vaccines. The SeV85AB-DNA immunization regimen induced higher levels of recall T cell responses after Mtb infection and conferred better immune protection compared with DNA-SeV85AB or a single immunization. Collectively,…
James T Gordy, Rowan E Bates, Elizabeth Glass, Jacob Meza, Yangchen Li, et al.
Tuberculosis disease (TB) caused by Mycobacterium tuberculosis (Mtb) bacteria remains a major cause of global morbidity and mortality. Efforts to control TB are hampered by the lengthy and cumbersome treatment required to eradicate the Mtb infection. Bacterial persistence during …
Harris RC, Quaife M, Weerasuriya C, Gomez GB, Sumner T, et al.
…r-olds. Vaccine trials should include adolescents to ensure vaccines can be delivered to this efficient-to-target population.
Asante KP, Mathanga DP, Milligan P, Akech S, Oduro A, et al.
Background The RTS,S/AS01 E malaria vaccine (RTS,S) was introduced by national immunisation programmes in Ghana, Kenya, and Malawi in 2019 in large-scale pilot schemes. We aimed to address questions about feasibility and impact, and to assess safety signals that had been observed…
Helen McShane
The dose of recombinant MVA used in the TB trials to date is relatively low compared with other trials using recombinant MVAs which have used up to 2.5 x 108pfu (A Hill, personal communication). Having demonstrated safety and immunogenicity of 5 x 107pfu of MVA85A, we now need to…
E Kırımi, Grace Gakii Muthuri, Cyrus Gitonga Ngari, Stephen Karanja
Numerous prevention intervention strategies have been developed to curtail the spread of pulmonary tuberculosis to susceptible populations. However, pulmonary tuberculosis continues to claim many lives worldwide. In this paper, a deterministic mathematical model incorporating an …
Constanza Estefanía Martínez-Olivares, Vasti Lozano-Ordaz, Dulce Mata‐Espinosa, Jorge Barrios‐Payán, Angel E. Ortiz-Cabrera, et al.
… aimed to experimentally validate these peptides as subunit vaccines by determining their cytotoxicity, immunogenicity, and protective efficacy against Mycobacterium tuberculosis (Mtb) in mice when administered as a booster to BCG vaccination. Mice were vaccinated with BCG and, t…
Helena Beckhäuser Ubaldo, Ketley Schnorrenberger, Líris Besen Wolniewicz
…dhood. Thus, analysis of vaccination coverage (VC) of these vaccines and its relationship with pertussis cases in children under one year may indicate the effectiveness of these strategies. To evaluate VC of dTpa in pregnant women and pentavalent vaccine, and its correlation with…
Kurtz SL, Mittereder LR, Lehman CC, Khan H, Gould VA, et al.
Tuberculosis is still the leading cause of death globally from any infectious disease, despite the widespread use of the live attenuated vaccine Bacille Calmette Guerin (BCG). While BCG has some efficacy against disseminated TB disease in children, protection wanes into adulthood…
Helena Beckhäuser Ubaldo, Ketley Schnorrenberger, Líris Besen Wolniewicz
…dhood. Thus, analysis of vaccination coverage (VC) of these vaccines and its relationship with pertussis cases in children under one year may indicate the effectiveness of these strategies. To evaluate VC of dTpa in pregnant women and pentavalent vaccine, and its correlation with…
Samaila Aboubacar, Soumana Alido, Kamayé Moumouni, Mamoudou Abdou Djafar, Garba Moumouni, et al.
Introduction: Tuberculosis remains a public health problem worldwide. The BCG vaccination is one of response means. The objective of this work was to study impact of BCG vaccination on morbidity and mortality related to childhood tuberculosis in Niamey. Patients and methods: It w…
Dana Ştefana Popescu, Anca Deleanu, Gindrovel Dumitra
Vaccine coverage for vaccines provided through the National Immunization Program is an element that is evaluated annually, including in Romania. Unfortunately, with the exception of the tuberculosis vaccine which has an optimal vaccine coverage (over 95%) both in total and in ar…
Khalid K, Poh CL
…c resistance crisis. To address this issue, next-generation vaccines are being developed to prevent antimicrobial resistance caused by MDR bacteria. Traditional vaccine platforms, such as inactivated vaccines (IVs) and live attenuated vaccines (LAVs), were effective in preventing…
Roordink D, Williams A, Fritzell B, Laddy DJ, Gerdil E, et al.
Two proof of concept clinical trials with TB vaccines demonstrate that new approaches can prevent sustained TB infection in adolescents (BCG revaccination) and TB disease in adults (M72/ASO1 E ) (Nemes et al., 2018; Tait et al., 2019) [1,2]. Both approaches are in late stage deve…