Showing 26–50 of 200 documents
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Leyla Larsson, Ioana Diana Olaru, Anna-Lisa Behnke, Edson T Marambire, Martha Chipinduro, et al.
**BACKGROUND:** Tuberculosis elimination is constrained by symptom-based and sputum-dependent diagnostic strategies, which miss asymptomatic disease and are difficult to deploy in community settings. Household contacts of people with tuberculosis are a priority population for scr…
Hueda-Zavaleta M, Gomez de la Torre JC, Minchón-Vizconde D, Barletta-Carrillo C, Copaja-Corzo C, et al.
Background Molecular tests have contributed to reducing the mortality rate through early and accurate diagnosis of tuberculosis (TB). This is due to their low processing complexity and diagnostic accuracy superior to conventional methods. Objective To evaluate the diagnostic perf…
Shyamkumar Sriram, Tareq Abualfaraj, Manal Ali Alsharif, Marwa Zalat, Saad Madani Alawfi, et al.
Patients with latent tuberculosis infection are mainly asymptomatic, but they still carry a notable risk of developing active TB, particularly when the host becomes immunosuppressed. Hence, appropriate diagnosis and management for LTBI are essential. Tuberculin skin test (TST) an…
Nattakarn Tantawarak, Keswadee Lapphra, Nirun Vanprapar, Orasri Wittawatmongkol, Wanatpreeya Phongsamart, et al.
**BACKGROUND:** Diagnosing pediatric pulmonary tuberculosis (PTB) remains challenging due to low bacterial load and difficulty obtaining specimens. Current guidelines recommend 3-day acid-fast bacilli (AFB) and culture, with 1 molecular testing. We aimed to compare diagnostic yie…
Giridharan P, Inbaraj LR, Frederick A, Selvaraju S, Ramraj B, et al.
Prevalence surveys and active case findings for tuberculosis (TB) typically use symptoms and Chest X-ray for screening and a diagnostic test for microbiological confirmation. We report the performance of screening and diagnostic tests from a state-wide prevalence survey in India.…
Yilin Wang, Zichun Ma, Zubi Liu, Xiaowei Dong, Wei Shu, et al.
…and support broader implementation. Integrating tongue swab diagnostics with existing TB control programs could enhance the detection accuracy, improve drug resistance monitoring and reduce transmissions.
Augustine J, Vijay A, Ramachandran D, Cleetus M, Nirmal AS, et al.
Background Establishing the etiology of exudative pleural effusions in the setting of an unrewarding pleural fluid analysis often requires biopsies from the parietal pleura. However, it may be noted that diagnosis such as pulmonary embolism and connective tissue diseases can resu…
Prakash Ghosh, Shaheda Anwar, Martin Siegel, Julius Boniface Okuni, Manfred Weidmann, et al.
**INTRODUCTION:** Early and accurate diagnosis of tuberculosis (TB) is central to ensuring the proper treatment and curbing the transmission of the disease. Despite the significant burden, the diagnosis of peripheral lymph node(LN)TB, the most prevalent form of extra pulmonary tu…
Ram Bahadur Khadka, Samrat Parajuli, Nabin Pahari
…int indicates the importance of integrating microbiological diagnostics into orthopedic practice in resource limited settings. It highlights key laboratory tools, outlines the barriers to their effective use, and proposes locally adaptable strategies to improve diagnostic accurac…
Johansen ØH, Abdissa A, Zangenberg M, Mekonnen Z, Eshetu B, et al.
Background Cryptosporidiosis is a common cause of diarrhoea in young children (aged younger than 24 months) in low-resource settings but is currently challenging to diagnose. Light-emitting diode fluorescence microscopy with auramine-phenol staining (LED-AP), recommended for tube…
Onya Opota, René Brouillet, Gilbert Greub, Katia Jaton
OBJECTIVES: In order to cope with the rapid spread of the COVID-19 pandemic, we introduced on our in-house high-throughput molecular diagnostic platform (MDx Platform) a real-time reverse transcriptase PCR (RT-PCR) to detect the SARS-CoV-2 from any clinical specimens. The aim of …
Jin Yin, Min Yu
**BACKGROUND:** For bacteriologically negative suspected tuberculosis, immunological testing provides important diagnostic evidence. The traditional tuberculin skin test has poor specificity. QuantiFERON-TB Gold Plus (QFT-Plus, the latest generation of Interferon-Gamma Release As…
Li L, Wang Y, Zhang R, Liu D, Li Y, et al.
Patients with tuberculous pleurisy often remain undiagnosed even after blind thoracentesis and closed pleural biopsy (PB). In this study, we assessed the value of computed tomography (CT)-guided core needle biopsy of pleural lesion and evaluated the diagnostic accuracy of polymer…
Udalamaththa Gamage Gihan Chamind, Krishantha Wickramasekara Rajapaksha Wimalagunarathne, H.L.S. Chathurika M.C. Mudannayake, Sunil De Alwis
Tuberculosis (TB) is prevalent in Sri Lanka and poses a considerable public health issue, even though the country is categorized as having a low burden of the disease.It ranks as the second most significant infectious disease in Sri Lanka, with around 500 to 600 fatalities each y…
Jin Ma, Lu Qi, Shan Tung Tu, Xiaoyan Miao, Juan Zhao
Background: Respiratory tract infection (RTI) is one of the most common diseases worldwide, and its incidence is rising year by year due to environmental pollution. Sputum culture remains the gold standard for RTI diagnosis, but its performance is limited by difficulties related …
Himanshu Jha, Chandra Prakash Baveja, Vinay Kamal, Prem Narayan Agarwal, Sonal Saxena, et al.
Background and Objectives . Tuberculosis has become a major health problem in India, and the incidence of tuberculous lymphadenitis (TBLN) has increased in parallel with the increase in the incidence of mycobacterial infection worldwide. Therefore, the main objective of this stud…
Wood RC, Luabeya AK, Dragovich RB, Olson AM, Lochner KA, et al.
Tongue dorsum swabbing is a potential alternative to sputum collection for tuberculosis (TB) testing. Previous studies showed that Cepheid Xpert MTB/RIF Ultra (Xpert Ultra) can detect Mycobacterium tuberculosis DNA on tongue swabs stored in buffer, with 72% sensitivity and 100% s…
Ahmadul Hasan Khan, Shakila Yeasmin, Sanjida Anjum, F Haque
Abstract Background Provision of early and accurate Tuberculosis (TB) diagnosis is crucial to end TB specially in a densely populated like Bangladesh. Molecular WHO-approved rapid diagnostic tests for TB (mWRDs) can significantly improve identification of undiagnosed TB cases. Th…
Sood M, Sharma S, Sood S, Sharma V
Tuberculosis is predicted to be a major undocumented cause of mortality in children. This systematic review with meta-analysis assessed the diagnostic accuracy of Lipoarabinomannan antigen testing (FujiLAM) in urine in HIV-negative children with TB-like signs and symptoms. PubMed…
Daniel Mukadi‐Bamuleka, Junior Bulabula-Penge, Bart K. M. Jacobs, Anja De Weggheleire, François Edidi-Atani, et al.
BACKGROUND: Ebola virus disease (EVD) outbreaks have emerged in Central and West Africa. EVD diagnosis relies principally on RT-PCR testing with GeneXpert®, which has logistical and cost restrictions at the peripheral level of the health system. Rapid diagnostic tests (RDTs) woul…
Mahato RP, Kumar S
Tuberculosis (TB) is still the most frequent cause of morbidity and mortality in the world caused by Mycobacterium tuberculosis (MTB). Due to slow diagnostic and treatment options, the disease is a major concern for public health and also increases the burden on the global econom…
Lu Zhang, Frederick L Altice, Adeeba Kamarulzaman, Ahsan Ahmad, Sangeeth Kaur, et al.
**BACKGROUND:** The World Health Organization (WHO) recommends tuberculosis (TB) screening in prisons but data on specific strategies are lacking. **METHODS:** Men sequentially entering Kajang Prison, Malaysia's largest prison, underwent standardized WHO symptom screening (SS), …
Luana Michelly Aparecida da Costa, Filipe Andrade Bernardi, Tiago Lara Michelin Sanches, Afrânio Lineu Kritski, Rafael Mello Galliez, et al.
…ee sharply the whole flow of processes in order to evaluate diagnostics cascades. Based on that, first, we developed a design of tuberculosis system operations in discrete-time based model, then we made a description of an agent-based transmission model developed to be incorporat…
Mamishi S, Pourakbari B, Sadeghi RH, Marjani M, Mahmoudi S
Introduction Several studies have been conducted to find new biomarkers for the discrimination of Latent Tuberculosis Infection (LTBI) from active TB (ATB); however, their findings are inconsistent. The aim of the current study was to evaluate the potential of in vitro antigenspe…
Moreira FMF, Verma R, Pereira Dos Santos PC, Leite A, da Silva Santos A, et al.
Background There is a need to identify scalable tuberculosis screening strategies among high burden populations. The WHO has identified a non-sputum-based triage test as a development priority. Methods We performed a diagnostic case-control study of point-of-care C-reactive prote…