Showing 1–25 of 200 documents
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Oudghiri A, Karimi H, Chetioui F, Zakham F, Bourkadi JE, et al.
Background The emergence of extensively drug-resistant tuberculosis (XDR-TB) has raised public health concern for global TB control. Although multi drug-resistant tuberculosis (MDR- TB) prevalence and associated genetic mutations in Morocco are well documented, scarce information…
Utpat KV, Rajpurohit R, Desai U
Background Drug-resistant tuberculosis (DR-TB) is the most exigent and calamitous challenge encountered in treatment of TB. Extra pulmonary (EP) DR-TB poses a complex diagnostic and therapeutic challenge owing to myriad of presentations and paucibacillary nature. Data available o…
Zifodya JS, Kreniske JS, Schiller I, Kohli M, Dendukuri N, et al.
…on (WHO)-recommended rapid tests that simultaneously detect tuberculosis and rifampicin resistance in people with signs and symptoms of tuberculosis. This review builds on our recent extensive Cochrane Review of Xpert MTB/RIF accuracy. Objectives To compare the diagnostic accurac…
Ayushi Sharma, Gyanendra Singh, Rahul Shrivastava
Tuberculosis is a global emergency. Despite two decades of intense research to understand and cure the disease, biological uncertainties prevail and hamper the therapeutic progress. Increasing incidences of multidrug-resistant (MDR) and extensively drug resistant (XDR) Mycobacter…
Bisson GP, Bastos M, Campbell JR, Bang D, Brust JC, et al.
…ociated with increased mortality during multidrug-resistant tuberculosis treatment, but the extent to which the use of antiretroviral therapy (ART) and anti-tuberculosis medications modify this risk are unclear. Our objective was to evaluate how use of these treatments altered mo…
Yoon Y, Seo H, Kim S, Lee Y, Rahim MA, et al.
Tuberculosis is a highly contagious disease caused by Mycobacterium tuberculosis . It affects about 10 million people each year and is still one of the leading causes of death worldwide. About 2 to 3 billion people (equivalent to 1 in 3 people in the world) are infected with late…
Seo H, Yoon Y, Kim S, Ghorbanian F, Tajdozian H, et al.
Background Tuberculosis is a highly contagious disease caused by Mycobacterium tuberculosis, and the increase in antibiotic resistance threatens humankind. Therefore, there is an urgent need to develop new anti-tuberculosis drugs that can overcome the limitations of existing drug…
Wu X, Yang J, Tan G, Liu H, Liu Y, et al.
…tigate the drug resistance characteristics of Mycobacterium tuberculosis (MTB) isolates from patients with tuberculosis to 12 antituberculous drugs in China. Methods: All clinical isolates of MTB were isolated from patients with tuberculosis in Shanghai Pulmonary Hospital (SPH) d…
Guerrero-Bustamante CA, Dedrick RM, Garlena RA, Russell DA, Hatfull GF
The global health burden of human tuberculosis (TB) and the widespread antibiotic resistance of its causative agent Mycobacterium tuberculosis warrant new strategies for TB control. The successful use of a bacteriophage cocktail to treat a Mycobacterium abscessus infection sugges…
Intini E, Kishore G, Udwadia ZF, Richeldi L
Tuberculosis is one of the top ten causes of death and the leading cause from a single infectious agent. Drug-resistant Tuberculosis continues to be a public health crisis. Urgent action is required to improve the coverage and quality of diagnosis, treatment and care for people w…
Jianguo Shi, Zhengqin Shi, Hao Li, Min Hu, Junbo Nan
…n in cancer patients clearly elevates the risk of acquiring tuberculosis (TB) infection, and traditional diagnostic methods are characterized by low sensitivity (Sen) and long turnaround times. Although the interferon-gamma release assay (IGRA) is widely used, its ability to dist…
Naz S, Farooq U, Ali S, Sarwar R, Khan S, et al.
Multi-drug-resistant tuberculosis and extensively drug-resistant tuberculosis has emerged as global health threat, causing millions of deaths worldwide. Identification of new drug candidates for tuberculosis (TB) by targeting novel and less explored protein targets will be invalu…
Hira Ashfaq, Ayesha Humayun, Muhammad Ahmad Naseem, Sarmad Wahaj Siddiqui, Asifa Kamal, et al.
…ROUND:** Globally, the prevalence of drug-resistant (DR-TB) tuberculosis is rising, and Pakistan is currently one of the nations with the highest burden. It is imperative to track changes in the prevalence of DR-TB, particularly the extensively drug-resistant (XDR-TB) tuberculosi…
Nwachukwu NO, Ulasi AE, Okoronkwo CU, Unegbu VN
Background Pre-extensively drug-resistant tuberculosis (Pre-XDR-TB), an emerging form of drug-resistant tuberculosis, is challenging efforts at tuberculosis control, leading to treatment failure among multidrug-resistant tuberculosis (MDR-TB) patients and progression to extensive…
Vaishnavi Vivekanandan, Arun K, Sindhu Hasini Doredla, Harini Ramanujam, Ranjani Singaraj, et al.
Tuberculosis (TB), caused by members of the Mycobacterium tuberculosis complex (MTBC), remains a significant global health concern. While zoonotic transmission of M. bovis from cattle to humans is well documented, reverse zoonotic transmission of M. tuberculosis from humans to ca…
Barilar I, Fernando T, Utpatel C, Abujate C, Madeira CM, et al.
…21, an estimated 4800 people developed rifampicin-resistant tuberculosis in Mozambique, 75% of which went undiagnosed. Detailed molecular data on rifampicin-resistant and multidrug-resistant (MDR) tuberculosis are not available. Here, we aimed at gaining precise data on the deter…
Jabbar A, Khan TA, Rehman H, Khan AS, Ahmad S, et al.
Objective To explore the burden of drug-resistant tuberculosis in Khyber Pakhtunkhwa, Pakistan. Methods The cross-sectional study was conducted from March 1, 2016, to February 28, 2017, at the Khyber Pakhtunkhwa Tuberculosis Reference Laboratory, Hayatabad Medical Complex, Peshaw…
Yang M, Zhan S, Fu L, Wang Y, Zhang P, et al.
Tuberculosis has become a great global public health threat. Compared with drug-susceptible tuberculosis (TB), the treatment regimens for multidrug-resistant tuberculosis (MDR-TB) and extensively drug-resistant tuberculosis (XDR-TB) involve more severe adverse events and poorer t…
Li Z, Liu F, Chen H, Han Y, You Y, et al.
…e-extensively drug-resistant plus additional drug-resistant tuberculosis (pre-XDR-plus) in Henan Provincial Chest Hospital between 2017 and 2021. Methods We analysed and summarized the drug sensitivity test (DST) results of clinical Mycobacterium tuberculosis (MTB) strains in TB …
Jaglal P, Pillay M, Mlisana K
Background Rapid diagnosis of drug-resistant Mycobacterium tuberculosis is a challenge in low-income countries. Phenotypic drug susceptibility testing using Sensititre ® MycoTB assay and the resazurin microtitre plate assay (REMA) are relatively new innovative methods to determin…
Mignani S, Tripathi VD, Soam D, Tripathi RP, Das S, et al.
The long-term treatment of tuberculosis (TB) sometimes leads to nonadherence to treatment, resulting in multidrug-resistant (MDR) and extensively drug-resistant (XDR) tuberculosis. Inadequate bioavailability of the drug is the main factor for therapeutic failure, which leads to t…
Xu X, Dong B, Peng L, Gao C, He Z, et al.
Mycobacterium tuberculosis possesses a dynamic cell envelope, which consists of a peptidoglycan layer, a mycolic acid layer, and an arabinogalactan polysaccharide. This envelope possesses a highly complex and unique structure representing a barrier that protects and assists the g…
Sheng-Nan Tang, Xi-Ling Huang, Alena Skrahina, Qiu-Ting Zheng, Aleh Tarasau, et al.
…wn to be more prevalent among multidrug-resistant pulmonary tuberculosis (MDR)/extensively drug-resistant tuberculosis (XDR) patients than among drug-sensitive tuberculosis (DS) patients. This study aims to clarify how the interaction betweenaggressiveness and tuberculosis histor…
Saerom Kim, Doosoo Jeon, Taehoon Lee, Seung Jun Lee, Ho Young Lee, et al.
…esistance status and trends in patients with extrapulmonary tuberculosis (EPTB) and compared them with those in patients with pulmonary tuberculosis (PTB). **METHODS:** The phenotypic drug susceptibility test (DST) results of patients with culture-confirmed tuberculosis (TB) dia…
Yenew B, Kebede A, Alemu A, Diriba G, Mehammed Z, et al.
Background The emergence of drug-resistant tuberculosis (DR-TB) has been a major obstacle to global tuberculosis control programs, especially in developing countries, including Ethiopia. This study investigated drug resistance patterns and associated mutations of Mycobacterium tu…