Showing 1–25 of 200 documents
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Thobani Ntshiqa, Jeniffer Nagudi, Yohhei Hamada, Andrew Copas, Stacie Stender, et al.
**BACKGROUND:** Although tuberculosis preventive therapy guidelines support testing for tuberculosis infection in household contacts (HHCs), this adds operational complexity and cost and has often been abandoned. To understand utility of testing, we determined prevalence and risk…
Khan PY, Paracha MS, Grundy C, Madhani F, Saeed S, et al.
Pakistan is one of the five highest tuberculosis burden countries globally. We estimated prevalence of adult bacteriologically confirmed pulmonary tuberculosis and annual risk of Mycobacterium tuberculosis (M. tuberculosis) infection in children aged 2-4 years in Karachi, Pakista…
Nsubuga G, Kennedy S, Rani Y, Hafiz Z, Kim S, et al.
Background The NOVA Tuberculosis Total Antibody Rapid Test is a commercially available lateral flow serological assay that is intended to be used as an aid in the diagnosis of tuberculosis. We conducted a study to estimate diagnostic accuracy of this assay for diagnosis of active…
Jeong D, Kang HY, Kim J, Lee H, Yoo BN, et al.
… aimed to review the current data composition of the Korean Tuberculosis and Post-Tuberculosis Cohort, which was constructed by linking the Korean Tuberculosis Surveillance System (KNTSS; established and operated by the Korean Disease Control and Prevention Agency since 2000) and…
Bitew A, Bati S
…infection is increasing and often misdiagnosed as pulmonary tuberculosis in developing countries where the prevalence of pulmonary tuberculosis is high. |Therefore, the purpose of this study is to determine the spectrum of potential pulmonary fungal pathogens and the prevalence o…
Musisi E, Sessolo A, Kaswabuli S, Zawedde J, Byanyima P, et al.
…ted the utility of a novel RNA-based quantitative test, the tuberculosis molecular bacterial load assay (TB-MBLA), for the detection and quantification of Mycobacterium tuberculosis in stool. Stools from 100 adult individuals were treated with OMNIgene-sputum reagent and tested u…
Umar F, Hatta M, Husain DR, Natzir R, Dwiyanti R, et al.
…ssion level of the Rv1250 efflux pump gene in Mycobacterium tuberculosis isolated from individuals with tuberculosis who received drug therapy, at the 1st, 3rd and 5th months, and newly diagnosed patients with tuberculosis who will receive drug therapy (0 month). The study was a …
Berhan A, Almaw A, Solomon Y, Legese B, Damtie S, et al.
Background Tuberculosis is a communicable disease, mainly caused by the bacillus Mycobacterium tuberculosis. Globally, TB is the ninth leading cause of death, with developing countries bearing most of the burden. The discovery of chemotherapy lead to significant improvements in p…
Berhan A, Almaw A, Solomon Y, Legese B, Damtie S, et al.
Background Tuberculosis is a communicable disease, mainly caused by the bacillus Mycobacterium tuberculosis. Globally, TB is the ninth leading cause of death, with developing countries bearing most of the burden. The discovery of chemotherapy lead to significant improvements in p…
Avula A, Ngu S, Mansour W, Gurala D, Maroun R
…ted with poor prognosis seen in advanced disease, laryngeal tuberculosis (LTB) now represents only 1% of all cases of tuberculosis (TB). The incidence of LTB has decreased drastically with the introduction of anti-tubercular drugs. LTB can be primary or secondary to pulmonary tub…
Abebe F, Belay M, Legesse M, K L M C F, Ottenhoff THM
…nvestigate protective and diagnostic immune markers against tuberculosis (TB), we measured antibody isotype responses to Mycobacterium tuberculosis (Mtb) antigens (LAM, Rv2031, and HBHA) in cohorts of 149 pulmonary tuberculosis patients (PTBP), 148 household contacts (HHCs), and …
Velayutham B, Chadha VK, Singla N, Narang P, Gangadhar Rao V, et al.
…formation on the proportion of new smear-positive pulmonary tuberculosis (PTB) patients treated with a 6-month thrice-weekly regimen under Revised National Tuberculosis Control Programme (RNTCP) who develop recurrent TB after successful treatment outcome. Objective To estimate TB…
Dashuki AR, Ruzlin ANM, Zamzuri MAIA, Chen XW
Introduction Tuberculosis (TB) is one of the major global health challenges and concerns. Despite the availability of effective treatment in Malaysia, it remained a consistently high notification rate of TB cases. The objective of this study was to determine the proportion of suc…
Sharma R, Prajapati S, Patel P, Patel B, Gajjar S, et al.
…spite the nationwide implementation of the Revised National Tuberculosis Control Program in India, adverse outcome after treatment is on rise. Program guidelines propose follow-up of cured patients for 2 years which is rarely done. Objectives The main objectives of this study is …
Malwe S, Bawiskar D, Wagh V
The revised National Tuberculosis (TB) Control Program is an initiative undertaken by the government of India and was active from 1997 to 2020. Later it was renamed as National TB Elimination Program, which eyes the complete eradication of TB by 2025. The revised National Tubercu…
Thibaut Morel-Journel, Christophe Guyeux, Christophe Sola
Lineage 1 is an ancestral lineage of the Mycobacterium tuberculosis complex (MTBC) comprising five sublineages. In a previous study, we suggested that a representative of sublineage L1.1.3, present in both Mozambique and northern Brazil, SIT129, may have been brought to Brazil by…
Kay AW, DiNardo AR, Dlamini Q, Kahari J, Mndzebele T, et al.
… are increasingly used in children to establish evidence of tuberculosis (TB) infection and to assist in the diagnosis of TB disease. The QuantiFERON-TB Gold In-Tube assay is being phased out in favor of a next-generation test, the QuantiFERON-TB Gold Plus (QFT-Plus) assay. The Q…
Alemu A, Diriba G, Seid G, Wondimu A, Moga S, et al.
Objectives To assess tuberculosis (TB) and associated factors among patients with presumptive TB with chronic kidney disease (CKD). Methods A prospective cross-sectional study was conducted from January to December 2023 among 381 patients with CKD attending six hospitals found in…
Khader Y, Al-Rahamneh MJ, Abu Khudair S, Abaza H, Al Shatnawi A, et al.
Objectives Evaluate and determine the gaps in the National Tuberculosis Program and Tuberculosis Surveillance System in Jordan. Methods A concurrent embedded mixed quantitative/qualitative methods study was conducted to assess the National Tuberculosis Program and Tuberculosis Su…
Bhargava A, Bhargava M, Meher A, Benedetti A, Velayutham B, et al.
Background In India, tuberculosis and undernutrition are syndemics with a high burden of tuberculosis coexisting with a high burden of undernutrition in patients and in the population. The aim of this study was to determine the effect of nutritional supplementation on tuberculosi…
Simon C Mendelsohn, Humphrey Mulenga, Michele Tameris, Tumelo Moloantoa, Stephanus T Malherbe, et al.
**BACKGROUND:** More than half of tuberculosis cases detected by community prevalence surveys are classified as asymptomatic. We evaluated yield of symptom and chest radiograph screening of tuberculosis-exposed household contacts in South Africa. **METHODS:** For this prospectiv…
Melike Hazal Can, Sedona Sweeney, Brian W Allwood, Susan E Dorman, Ted Cohen, et al.
**BACKGROUND:** Untreated pulmonary tuberculosis causes ongoing lung damage, which can persist after treatment. Conventional modelling approaches for assessing tuberculosis health effects might not fully capture these mechanisms. We evaluated how tuberculosis-associated lung dama…
da Costa FBP, Nicol MP, Botha M, Workman L, Arcêncio RA, et al.
Background Paediatric tuberculosis leads to more than 200 000 deaths annually. We aimed to investigate the incidence of Mycobacterium tuberculosis infection and tuberculosis disease in the first decade of life in the Drakenstein Child Health Study (DCHS), a South African cohort i…
Marcy O, Goyet S, Borand L, Msellati P, Ung V, et al.
Background There is no gold standard for tuberculosis diagnosis in children. Clinical Case Definitions for Classification of Intrathoracic Tuberculosis in Children were proposed by international experts in 2012 and updated in 2015. We aimed to compare the 2012 and 2015 Clinical C…
Saunders MJ, Wingfield T, Datta S, Montoya R, Ramos E, et al.
…eness of social protection and biomedical interventions for tuberculosis-affected households might be improved by risk stratification. We therefore derived and externally validated a household-level risk score to predict tuberculosis among contacts of patients with tuberculosis. …