Showing 1–25 of 51 documents
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Namburete E
Abstract Background Knowing the genetic diversity of M. tuberculosis strains causing drug-resistant tuberculosis (DR-TB) in high burden TB and low resources countries such as Mozambique is a key factor to TB disease spread control and world TB epidemic control. Whole-genome seque…
Podlekareva DN, Folkvardsen DB, Skrahina A, Vassilenko A, Skrahin A, et al.
Background To cure drug-resistant (DR) tuberculosis (TB), the antituberculous treatment should be guided by Mycobacterium tuberculosis drug-susceptibility testing (DST). In this study, we compared conventional DST performed in Minsk, Belarus, a TB DR high-burden country, with ext…
Conceição EC, Loubser J, Guimarães AEDS, Sharma A, Rutaihwa LK, et al.
… Pará, Northern Brazil, described a strain of Mycobacterium tuberculosis with a unique genotype (SIT2517/T1) associated with multidrug-resistant tuberculosis (MDR-TB). To improve our understanding of MDR-TB transmission dynamics of these strains within this region, we performed p…
Pinhata JMW, Brandao AP, Mendes FF, Rabello MCDS, Ferrazoli L, et al.
…and isoniazid phenotypic resistance levels in Mycobacterium tuberculosis isolates from drug-resistant TB patients from São Paulo state, Brazil. Isolates resistant to the critical concentration of isoniazid in MGIT (0.1 µg/mL) were screened for mutations in katG 315 codon, inhA pr…
Zhang X, Chen X, Wang B, Fu L, Huo F, et al.
…olones (FQs) are the cornerstone in treating drug-resistant tuberculosis (TB); the prevalence of TB among the population is diverse in different regions, understanding the relationship between resistance pattern and molecular characteristic of FQs in preextensive drug-resistant (…
Dagne B, Desta K, Fekade R, Amare M, Tadesse M, et al.
Background Drug-resistance in Mycobacterium tuberculosis complex remains a major health burden in human history and still is a major leading cause of death in developing countries including Ethiopia. Early detection of all forms of drug-resistant Tuberculosis(TB) is a key factor …
Ismail NA, Omar SV, Moultrie H, Bhyat Z, Conradie F, et al.
…nts with rifampicin-resistant and multidrug-resistant (MDR) tuberculosis; however, emerging resistance threatens this success. We did a cross-sectional and longitudinal analysis evaluating the epidemiology, genetic basis, and treatment outcomes associated with bedaquiline resista…
Diriba G, Kebede A, Tola HH, Alemu A, Yenew B, et al.
Background In Ethiopia, tuberculosis (TB) is one of the most common causes of illness and death. However, there is limited information available on lineages associated with drug resistance among extrapulmonary tuberculosis patients in Ethiopia. In this study, researchers looked i…
Bhosale S, Prabhakar A, Srivastava S, Raj A, Purohit S, et al.
…ign Retrospective observational analysis. Objectives Spinal tuberculosis accounts for about 50% of cases among extra pulmonary osteoarticular tuberculosis. Resistance to drugs in spinal tuberculosis patients is on a rise and there is inadequate literature concentrating on the pre…
Katran ZY, Bulut İ, Babalık A, Keren M, Tepetam FM, et al.
Objective To evaluate drug resıstant tuberculosis patients who developed drug hypersensitivity to antituberculosis drug. Methods This was a retrospective study. The primary aim of the study is to determine the demographic and clinical characteristics of patients who develop drug …
Breli Bonheur Ngouama, Jean Claude Djontu, Darrel Ornelle Elion Assiana, Freisnel Hermeland Mouzinga, Mita Naomie Merveille Dello, et al.
**BACKGROUND:** WHO strategy to end Tuberculosis (TB) calls for drug susceptibility testing of Mycobacterium tuberculosis (MTB) for all patients, in high TB burden settings. Thus, this study aimed to investigate the MTB drug resistance profiles and related risk factors among pati…
Radhika R, Tullu MS, Shamla O, David J
Abstract Tuberculosis as cause of mediastinal mass, is rare in children, and may be seen in immunodeficiencies. Data on the prevalence of mediastinal tuberculosis and on its clinical spectrum and outcome is lacking in children. A 4.5-month-old boy presented with fever and cough s…
Jain P, Singh U, Kumar V, Ratnam R, Jain A
…the WHO as the screening test for diagnosing extrapulmonary tuberculosis (EPTB). In the present study we report the agreement between CBNAAT (Xpert MTB/RIF), liquid culture (LC) and line probe assay (LPA) for diagnosis of Mycobacterium tuberculosis and detection of drug resistanc…
Dana Auganova, Sabina Atavliyeva, Nour Gharbi, Elena Zholdybayeva, Yuri Skiba, et al.
… data on the genomic diversity of circulating Mycobacterium tuberculosis strains in Kazakhstan remains limited. We performed whole-genome sequencing on 177 clinical M. tuberculosis isolates belonging to the L2/Beijing lineage, sourced from 15 regions across Kazakhstan. WGS data w…
Kostyukova I, Pasechnik O, Mokrousov I
Russia is a high-burden area for multidrug-resistant tuberculosis (MDR-TB). Here, we studied the epidemiological situation and drug resistance patterns of Mycobacterium tuberculosis in the Omsk region in Western Siberia. M. tuberculosis isolates ( n = 851) were recovered from new…
Liang D, Song Z, Liang X, Qin H, Huang L, et al.
Background Tuberculosis (TB), caused by Mycobacterium tuberculosis ( Mtb ), is a major public health issue in China. Nevertheless, the prevalence and drug resistance characteristics of isolates vary in different regions and provinces. In this study, we investigated the population…
Linhares LA, Dos Santos Peixoto A, Correia de Sousa LA, Lucena Laet JP, da Silva Santos AC, et al.
Tuberculosis remains a major public health problem and one of the top ten causes of death worldwide. The alarming increase in multidrug-resistant and extensively resistant variants (MDR, pre-XDR, and XDR) makes the disease more difficult to treat and control. New drugs that act a…
Zhdanova S, Jiao WW, Sinkov V, Khromova P, Solovieva N, et al.
…pic and genotypic drug resistance patterns of Mycobacterium tuberculosis strains from children with tuberculosis (TB) in China and Russia, two high-burden countries for multi/extensively-drug resistant (MDR/XDR) TB. Whole-genome sequencing data of M. tuberculosis isolates from Ch…
Morey-León G, Andrade-Molina D, Fernández-Cadena JC, Berná L
Background Tuberculosis is a serious infectious disease affecting millions of people. In spite of efforts to reduce the disease, increasing antibiotic resistance has contributed to persist in the top 10 causes of death worldwide. In fact, the increased cases of multi (MDR) and ex…
Fernandez Do Porto DA, Monteserin J, Campos J, Sosa EJ, Matteo M, et al.
…nd Whole-genome sequencing has shown that the Mycobacterium tuberculosis infection process can be more heterogeneous than previously thought. Compartmentalized infections, exogenous reinfections, and microevolution are manifestations of this clonal complexity. The analysis of the…
Ushtanit A, Mikhailova Y, Krylova L, Grigorash D, Makarova M, et al.
The emergence of drug-resistant tuberculosis forced the development of new drugs and the screening of more effective or less toxic analogues. Mycolic acid biosynthesis is targeted by several antituberculosis drugs, isoniazid being one of the most important in tuberculosis therapy…
Renji S, Solomon R, Wankhade D, Udani S, Udani V
…children admitted in our PICU with bacteriologically proven tuberculosis (smear, culture, poly-merase chain reaction, genotypic testing or Pyrosequencing) between January, 2007 and December, 2019 were retrieved. Drug resistance was classified as per World Health Organization defi…
Vyazovaya A, Levina K, Zhuravlev V, Viiklepp P, Kütt M, et al.
…ives We assessed the genetic structure of the Mycobacterium tuberculosis population in Estonia with a special focus on major epidemic/endemic clones and drug resistance determinants. We investigated the hypothesis of the decisive impact of massive human influx on the locally circ…
Ghosh A, Biswas VK, Bal HB, Das D, Pati S, et al.
…ng has been used to investigate the genomic diversity of M. tuberculosis in the northern and southern states of India, but information about the eastern part of the country is still limited. Through a sequencing-based strategy, this study seeks to comprehend the diversity and dru…
Liang Z, Liao W, Chen Q, Li H, Ye M, et al.
…is the most devastating and critical form of extrapulmonary tuberculosis. Here, we present a case of a 45-year-old male with pre-extensive drug-resistant tuberculosis meningitis (pre-XDR-TBM). He underwent emergency surgery for the long-tunneled external ventricular drainage (LTE…