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Seo WJ, Koo HK, Kang JY, Kang J, Park SH, et al.
…ackground The Center for Personalized Precision Medicine of Tuberculosis (cPMTb) was constructed to develop personalized pharmacotherapeutic systems for tuberculosis (TB). This study aimed to introduce the cPMTb cohort and compare the distinct characteristics of patients with TB,…
Luo Y, Xue Y, Tang G, Lin Q, Song H, et al.
Background Novel approaches for tuberculosis (TB) diagnosis, especially for distinguishing active TB (ATB) from latent TB infection (LTBI), are urgently warranted. The present study aims to determine whether the combination of HLA-DR on Mycobacterium tuberculosis (MTB)-specific c…
Barik BS, Kar CD, Das S, Hussain T, Nayak S, et al.
Introduction Contacts of tuberculosis (TB) patients have an increased risk of latent TB infection (LTBI). Currently, it is diagnosed using one of the two methods: Tuberculin skin test (TST) or QuantiFERON-TB Gold Plus. This study aims to estimate the concordance of TST and QFT-TB…
Mao L, Xu L, Wang X, Du J, Sun Q, et al.
… expressed over the reactivation from dormant Mycobacterium tuberculosis (M. tuberculosis) could be used to diagnose tuberculosis (TB) at different stages. We performed a retrospective cohort study based on four groups, including healthy controls (HCs), active tuberculosis infect…
Cole B, Nilsen DM, Will L, Etkind SC, Burgos M, et al.
This report provides an introduction and reference tool for tuberculosis (TB) controllers regarding the essential components of a public health program to prevent, control, and eliminate TB. The Advisory Council for the Elimination of Tuberculosis and the National Tuberculosis Co…
Zhang L, Ma H, Wan S, Zhang Y, Gao M, et al.
Background Differential diagnosis of active tuberculosis (ATB) and latent tuberculosis infection (LTBI) has been a challenge for clinicians in high TB burden countries. The purpose of this study was to improve the accuracy of differential diagnosis of ATB and LTBI by using fluore…
Holmberg P, Janoušková M, Schmidt T, Neumann A, Olsson O, et al.
Background Interferon-γ release assays (IGRAs) for tuberculosis infection (TBI) cannot distinguish different stages of the TBI spectrum (including spontaneously cleared infection). We investigated patterns of Mtb-specific blood mediators in people with and without TBI during tube…
Pan SW, Su WJ, Chan YJ, Chuang FY, Feng JY, et al.
Objectives The timely diagnosis of pulmonary tuberculosis (PTB) is challenging. Although pathogen-derived circulating cell-free DNA (cfDNA) has been detected in humans, the significance of Mycobacterium tuberculosis (MTB)-cfDNA detection in patients with PTB remains unclear. Meth…
Luo Y, Xue Y, Yuan X, Lin Q, Tang G, et al.
… is no rapid and effective method for distinguishing active tuberculosis (ATB) from latent tuberculosis infection (LTBI), the discrimination between these two statuses remains challenging. This study sought to investigate the value of nutritional indexes and tuberculosis-specific…
Luo Y, Xue Y, Mao L, Lin Q, Tang G, et al.
…ackground Rapid and effective discrimination between active tuberculosis (ATB) and latent tuberculosis infection (LTBI) remains a challenge. There is an urgent need for developing practical and affordable approaches targeting this issue. Methods Participants with ATB and LTBI wer…
Zhang L, Li Y, Zou X, Ma H, Gao M, et al.
…aims to evaluate the diagnostic accuracy of a Mycobacterium tuberculosis (MTB)-specific triple-color FluoroSpot assay (IFN-γ/IL-2/TNF-α) in the differentiation of tuberculosis (TB) infection status in febrile patients. Method Febrile patients with suspected active TB (ATB) were c…
Teklu T, Wondale B, Taye B, Hailemariam M, Bekele S, et al.
Background Tuberculosis (TB) is one of the world's most problematic infectious diseases. The pathogen Mycobacterium tuberculosis (Mtb) is contained by the immune system in people with latent TB infection (LTBI). No overt disease symptoms occur. The environmental and internal trig…
Karaca C, Ozer F, Sevim DG, Erdoğan O, Unlu M
We present a case series of eight patients with ocular tuberculosis (OTB), latent tuberculosis (TB) or sarcoidosis, some of whom were receiving anti-tumor necrosis factor alpha (anti-TNF-α) therapy for various systemic diseases. Only one patient had a positive QuantiFERON®-TB tes…
Arroyo L, Marín D, Franken KLMC, Ottenhoff THM, Barrera LF
Background Tuberculosis (TB) remains one of the most deadly infectious diseases. One-third to one-fourth of the human population is estimated to be infected with Mycobacterium tuberculosis (Mtb) without showing clinical symptoms, a condition called latent TB infection (LTBI). Dia…
Goletti D, Delogu G, Matteelli A, Migliori GB
…arter of the global population is infected by Mycobacterium tuberculosis (Mtb). A better control of tuberculosis (TB) is based on the ability to detect Mtb infection, identifying the progressors to TB disease, undergoing to preventive therapy and implementing strategies to regist…
Luo Y, Xue Y, Lin Q, Tang G, Yuan X, et al.
Background Discriminating active tuberculosis (ATB) from latent tuberculosis infection (LTBI) remains challenging. This study aimed to investigate a diagnostic model based on a combination of iron metabolism and the TB-specific antigen/phytohemagglutinin ratio (TBAg/PHA ratio) in…
Luo Y, Tang G, Lin Q, Mao L, Xue Y, et al.
Objectives Distinguishing between active tuberculosis (ATB) and latent tuberculosis infection (LTBI) remains challenging. Methods The modified T-SPOT.TB assay was performed in 499 participants (243 ATB and 256 LTBI) and another 322 participants (162 ATB and 160 LTBI) who were dia…
Benachinmardi K, Sampath S, Rao M
Background : Detection of latent tuberculosis infection (LTBI) in children, exposed to tuberculosis (TB) infections, followed by appropriate treatment, could be instrumental in reducing TB burden. Interferon Gamma release assays (IGRA) have higher specificity than tuberculin skin…
Gong W, Wu X
As an ancient infectious disease, tuberculosis (TB) is still the leading cause of death from a single infectious agent worldwide. Latent TB infection (LTBI) has been recognized as the largest source of new TB cases and is one of the biggest obstacles to achieving the aim of the E…
Kapata N, Tembo J, Mwaba P, Nabyonga-Orem J, Ntoumi F, et al.
Tuberculosis (TB) remains a leading cause of morbidity and mortality in Africa, with latent TB infection (LTBI) and TB co-infections posing significant public health challenges. This viewpoint examines the undiagnosed burden of LTBI and TB co-infections across the continent, emph…
Kamolratanakul S, Ariyanon W, Udompornpitak K, Bhunyakarnjanarat T, Leelahavanichkul A, et al.
…r how the immune system controls the transition from latent tuberculosis (TB) infection (LTBI) to active pulmonary infection (PTB). Here, we applied mass spectrometry cytometry time-of-flight (CyTOF) analysis of peripheral blood mononuclear cells to compare the immunological land…
Chang CJ, Huang JR, Tseng YH, Pan SW, Feng JY, et al.
… of circulating cell-free DNA (cfDNA) differentiates active tuberculosis (TB) from latent TB infection (LTBI). Methods Patients with pulmonary TB, contacts with LTBI, and healthy controls were enrolled (2018-2021). Plasma cfDNA was extracted, and using a 5-methylcytosine (5mC) DN…
Woodruff R, Pratt R, Kolasa M
Problem/condition Elimination of tuberculosis (TB) is defined as reducing TB disease incidence in the United States to less than 1 case per million persons per year. In 2022, TB incidence in the United States was 2.5 TB cases per 100,000 persons. CDC's TB program developed a set …
Sharma N, Bakshi R, Basu S, Zode M, Arora R, et al.
…nitiation, implementation and treatment completion rates of tuberculosis (TB) preventive therapy (TPT) using 3HP (INH-Rifapentine) among household contacts of microbiologically confirmed drug sensitive TB cases on anti-tubercular treatment under programmatic real-world settings. …
Plans-Rubió P, Godoy S, Toledo D, Domínguez A, Caylà J, et al.
…dy was to identify factors associated with non-adherence to tuberculosis (TB) preventive treatment among contacts with latent TB infection for new cases of pulmonary TB cases reported in Catalonia in 2019-2021. All contacts aged 18 years or older with a latent TB infection who re…