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Xie K, Zhang Y, Zhang M, Wu H, Zheng L, et al.
…e disease. VDD is also associated with an increased risk of HIV-related comorbidities and mortality, and patients have a tendency to develop active tuberculosis compared to those with latent tuberculosis infection. Vitamin D supplementation may modulate HIV replication, improve T…
Balfour A, Schutz C, Goliath R, Wilkinson KA, Sayed S, et al.
…l numbers generally decrease in patients with active TB and HIV infection, but findings regarding functional changes differ. Methods: We conducted a cross-sectional study on the effect of HIV, TB, and HIV-associated TB (HIV-TB) on MAIT cell frequencies, activation and functional …
Teng VYM, Chua YT, Lai EEN, Mukherjee S, Michaels J, et al.
Objectives To examine the prevalence and characteristics of HIV-tuberculosis (TB) co-infected patients in Singapore, an intermediate TB-burden country. Methods Retrospective data across 11 years was obtained from the National University Hospital (NUH), a quaternary hospital and t…
Gebremicael G, Alemayehu M, Sileshi M, Geto Z, Gebreegziabxier A, et al.
…s with five clinical groups: 57 TB patients coinfected with HIV (HIV+TB+), 87 active TB Patients (TB cases), 71 HIV infected without active and latent TB infection (HIV+TST-), 22 latent TB infection (TST+) and 25 healthy controls (TST-). Vitamin A concentration was measured using…
Winter JR, Stagg HR, Smith CJ, Lalor MK, Davidson JA, et al.
Background HIV increases the progression of latent tuberculosis (TB) infection to active disease and contributed to increased TB in the UK until 2004. We describe temporal trends in HIV infection amongst patients with TB and identify factors associated with HIV infection. Methods…
de Vries G, van de Berg S, van Dam A, Hasanova S, Pareek M, et al.
…ated 12% of tuberculosis (TB) patients are co-infected with HIV in the World Health Organization European Region (the Region). Reducing morbidity and mortality from HIV-associated TB requires strong collaboration between TB and HIV services at all levels with integrated people-ce…
Habibi P, Daniell H, Soccol CR, Grossi-de-Sa MF
Tuberculosis (TB) and human immunodeficiency virus (HIV) can place a major burden on healthcare systems and constitute the main challenges of diagnostic and therapeutic programmes. Infection with HIV is the most common cause of Mycobacterium tuberculosis (Mtb), which can accelera…
Rewari BB, Kumar A, Mandal PP, Puri AK
Introduction : HIV and tuberculosis (TB) are two of the most challenging infections faced by humanity and place immense burden on health care systems worldwide. Both HIV and TB impact one another's progression. Areas covered : HIV is the most important risk factor for progression…
Liu Q, Yu C, Cheng J, Jiang Y, Xu Y, et al.
…cells, but also highly expressed on the T cells membrane in HIV-1 negative patients with tuberculosis (TB). However, the study on membrane-bound IL-22+ cells of HIV-1 infected patients is rare. Therefore, we investigated antigen-specific membrane-bound IL-22+ T cell subsets in My…
Riti Sharan, Yi Zou, Bindu Singh, Vinay Shivanna, Edward J Dick, et al.
Most HIV-negative individuals exposed to Mycobacterium tuberculosis (Mtb) control infection as latent TB infection (LTBI), but HIV co-infection greatly increases progression to tuberculosis (TB), the leading cause of death in people living with HIV (PLHIV). Although combination a…
Catherine Keiko Gunawan, Anton Sumarpo, Agnes Rengga Indrati
…ysregulation is a hallmark of human immunodeficiency virus (HIV) infection, characterized by persistent immune activation and systemic inflammation that drive T cell exhaustion and senescence, contributing to disease progression and non-AIDS comorbidities, most notably tuberculos…
Semá Baltazar C, DeLima YV, Ricardo H, Botão C, Chitsondzo Langa D, et al.
…d As part of ongoing efforts to generate evidence needed on HIV and tuberculosis (TB) to inform policies and programs aimed to improve the health outcomes of migrants and communities affected by migration and mining, a preliminary investigation was conducted through a biological …
Mangochi P, Bossard C, Catacutan C, Van Laeken D, Kwitonda C, et al.
BACKGROUND Incarcerated individuals, especially in high HIV and TB burden settings, are at increased risk of latent TB infection and/or TB disease. We implemented a comprehensive HIV-TB intervention in a Malawi prison and studied its feasibility. METHODS Between February and Dece…
Gemechu LL, Debusho LK
An in-depth analysis of the epidemiological patterns of TB/HIV co-infection is essential since it helps to target high-risk areas with effective control measures. The main objective of this study was to assess the spatial clustering of TB/HIV co-infection prevalence in Ethiopia f…
Weld ED, Dooley KE
…pregnant and postpartum women experience an undue burden of HIV-associated tuberculosis (TB), but data are lacking on key aspects of their complex management. Often excluded from clinical trials, they are left with limited options for HIV-TB cotreatment. This review will focus on…
Duffy FJ, Thompson EG, Scriba TJ, Zak DE
…d by co-infection with Mycobacterium tuberculosis (Mtb) and HIV, the leading cause of death for HIV-infected individuals. Improved characterization of Mtb/HIV coinfection as a distinct disease state may lead to better identification and treatment of affected individuals. Methods …
Vecchione MB, Eiras J, Suarez GV, Angerami MT, Marquez C, et al.
…th among infectious diseases. Human immunodeficiency virus (HIV) infection is a main predisposing factor to TB reactivation. Individuals HIV-TB co-infected develop a chronic state of inflammation associated with hypothalamic-pituitary-adrenal (HPA) axis dysregulation. This result…
Judi Chen, Weining Cao, Renfang Chen, Yong Ren, Tao Li
…34 million people living with human immunodeficiency virus (HIV) worldwide are infected with latent tuberculosis (TB). The aim of this study was to determine the rate of HIV infection in TB patients and its determinants in Wuxi City, China. TB patients attending health institutio…
Mupfumi L, Mpande CAM, Reid T, Moyo S, Shin SS, et al.
…nce of host blood-based biomarkers for tuberculosis (TB) in HIV-infected patients on antiretroviral therapy (ART) has not been fully assessed. We evaluated the immune phenotype and functionality of antigen-specific T-cell responses in HIV positive (+) participants with TB (n = 12…
Wong NS, Leung CC, Chan KCW, Chan WK, Lin AWC, et al.
Latent TB infection (LTBI) in HIV patients, its treatment, and immunological recovery following highly active antiretroviral therapy (HAART) could interact and impact TB disease progression. We aim to examine the factors associated with LTBI and TB disease development among HIV p…
Birku M, Desalegn G, Kassa G, Tsegaye A, Abebe M
…e the effect of pregnancy and Human immunodeficiency virus (HIV) infection on detection performances of tuberculin skin test (TST) and QuantiFERON-TB Gold In-Tube (QFTGIT) for the diagnosis of latent tuberculosis infection (LTBI) among women living in high TB and HIV endemic sett…
Petruccioli E, Chiacchio T, Navarra A, Vanini V, Cuzzi G, et al.
Objective HIV-infection increases the risk to progress to active-tuberculosis (TB). Detection of latent TB infection (LTBI) is needed to eventually propose preventive-therapy and reduce TB reservoir. QuantiFERON-TB Plus (QFT-Plus)-test identifies LTBI. Currently, only two studies…
Hormi M, Guérin-El Khourouj V, Pommelet V, Jeljeli M, Pédron B, et al.
…ERON to assist the diagnosis of active tuberculosis (TB) in HIV-infected children are limited, especially in countries with low incidence of TB/HIV coinfection. Methods QuantiFERON results were analyzed in 63 HIV-infected children who presented to our hospital in Paris, France. S…
Fernando R, McDowell AC, Bhavaraju R, Fraimow H, Wilson JW, et al.
…ackground Persons living with human immunodeficiency virus (HIV) are at a greater risk of developing tuberculosis (TB) compared to people without HIV and of developing complications due to the complexity of TB/HIV coinfection management. Methods During 2013-2017, the Centers for …
Chendi BH, Tveiten H, Snyders CI, Tonby K, Jenum S, et al.
…uberculosis (TB) disease from latent TB infection (LTBI) in HIV uninfected and infected individuals enrolled in TB low-burden countries. Design Participants with TB disease (N = 85) and LTBI (N = 150) were recruited from prospective cohorts at hospitals in Norway and Denmark. Pla…