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Gómez LM, Paniagua-Saldarriaga LA, Richert Q, Keynan Y, Montes F, et al.
…e risk factors associated with unsuccessful TB treatment in HIV-seropositive and homeless persons, compared with non-HIV-infected and non-homeless persons with TB. We conducted a retrospective cohort study using observational, routinely collected health data from all drug-suscept…
Saadick Mugerwa Ssentongo, Kenneth Kwenya, Bonniface Oryokot, Ronald Opito, Susan Alwedo, et al.
…with 500,000 people dying of Tb in 2021. People living with HIV have an 18 times higher risk of having TB, which is associated with poor treatment outcomes. This study aimed to determine the treatment success rate and associated factors among Pulmonary Clinically Diagnosed and Ba…
Naidoo A, Dooley KE, Naidoo K, Padayatchi N, Yende-Zuma N, et al.
Introduction Cotreatment of HIV and tuberculosis (TB) reduces morbidity and mortality in coinfected patients. Availability of antiretroviral treatment (ART) drug options, including within drug classes, is important, particularly in high HIV/TB burden low and middle-income countri…
Saag L, Rebeiro P, Cordeiro-Santos M, Kritski A, Andrade B, et al.
…redictor of poor tuberculosis (TB) treatment outcomes among HIV-negative populations, but the relationship has not been well studied in the context of HIV. We examined the association between HIV and weight change during the first two months of anti-tuberculosis treatment, and al…
Naidoo K, Dookie N, Naidoo K, Yende-Zuma N, Chimukangara B, et al.
…rent tuberculosis (TB) following TB treatment completion in HIV-infected individuals remains a major public health burden. We assessed the role of various risk factors in mediating the development of recurrent TB and subsequent resistance to antiretroviral therapy and anti-TB dru…
Oriekot A, Sereke SG, Bongomin F, Bugeza S, Muyinda Z
…crobiologically confirmed DS and RR PTB cases stratified by HIV serostatus in Uganda. Methods We conducted a hospital-based retrospective study at the Mulago National Referral Hospital (MNRH) TB wards. All participants had a microbiologically confirmed diagnosis of PTB. CXR findi…
Wang L, Lv H, Zhang X, Zhang X, Bai J, et al.
…s of co-infection between the human immunodeficiency virus (HIV) and drug-susceptible tuberculosis (DS-TB) in different countries, across various age groups and genders. We obtained data on the number of cases, age-standardized incidence rate, age-standardized prevalence rate, ag…
Wang L, Lv H, Zhang X, Zhang X, Bai J, et al.
…s of co-infection between the human immunodeficiency virus (HIV) and drug-susceptible tuberculosis (DS-TB) in different countries, across various age groups and genders. Methods We obtained data on the number of cases, age-standardized incidence rate, age-standardized prevalence …
Ndlovu LN, Peetluk L, Moodley S, Nhamoyebonde S, Ngoepe AT, et al.
…ne, as well as during TB treatment in 79 patients [50 (63%) HIV-positive] with microbiologically confirmed drug susceptible TB undergoing standard treatment. At time of diagnosis, blood neutrophils were highly expanded and surface expression of the neutrophil marker CD15 greatly …
Junhui Wu, Guangqi Han, Disha Zhu, Weixuan Wang, Shaomei Shang
BackgroundHIV and drug-susceptible tuberculosis (DS-TB) co-infection severely affects adolescents and young adults (10-24 years), leading to a significant infectious disease burden, yet this age group remains overlooked. This study assessed the 1990-2021 global, regional, and nat…
McDonald AK, Nakkonde D, Kaggwa P, Zalwango S, Joseph A, et al.
…da. We collected data on demographics, TB-related symptoms, HIV status, and disability measured using the World Health Organization Disability Assessment Schedule (WHODAS 2.0). Results Of the 200 participants, the median age was 33.0 years (IQR 26-44.5); 52.5% were male, and 23% …
Cumming BM, Addicott KW, Maruri F, Pillay V, Asmal R, et al.
…ents were severely impaired in comparison to non-TB and non-HIV-infected controls. However, most bioenergetic parameters were not affected by HIV status or glycemic index. Treatment of TB patients restored the % spare respiratory capacity (%SRC) of the circulating lymphocytes to …
Osman M, van Schalkwyk C, Naidoo P, Seddon JA, Dunbar R, et al.
In 2011, the South African HIV treatment eligibility criteria were expanded to allow all tuberculosis (TB) patients lifelong ART. The impact of this change on TB mortality in South Africa is not known. We evaluated mortality in all adults (≥ 15 years old) treated for drug-suscept…
Chabala C, Turkova A, Thomason MJ, Wobudeya E, Hissar S, et al.
…ren aged below 16 years with non-severe TB, with or without HIV infection. The primary efficacy and safety endpoints are TB disease-free survival 72 weeks post randomisation and grade 3 or 4 adverse events. Nested pharmacokinetic studies will evaluate anti-tuberculosis drug conce…
V Shukatka, L Skoklyuk, M Germanovych, A Bogdanov, T Ivanenko, et al.
**BACKGROUND:** Ukraine faces intersecting epidemics of HIV and drug-resistant TB (DR-TB), with high risk of progression from TB infection to active disease. The Support TB Control Efforts in Ukraine project supported the National TB Program's efforts to operationalise World Heal…
Kerkhoff AD, Havlir DV
…rapy hold promise for reducing TB incidence in persons with HIV in high-burden settings. In persons who develop drug-susceptible TB, progress to shorten TB treatment continues to be made with the introduction of new drugs and novel treatment strategies that could allow for treatm…
Burusie A, Enquesilassie F, Salazar-Austin N, Addissie A
…), age less than 10 years (aRR = 2.69; 95% CI = 1.56-4.61), HIV infection (aRR = 2.62; 95% CI = 1.50-4.59), and relapsed TB (aRR = 3.19; 95% CI = 1.79-4.71) were independent predictors of unfavorable TB treatment outcomes. When we looked separately at children who had been on TB …
Seid MA, Ayalew MB, Muche EA, Gebreyohannes EA, Abegaz TM
…Nations (83%), Tigray (85%) and Afar (86%). Mainly old age, HIV co-infection, retreatment cases and rural residence were the most frequently identified factors associated with poor TB treatment outcome. Conclusion The result of this study revealed that the overall TB treatment su…
Oladimeji O, Adepoju V, Anyiam FE, San JE, Odugbemi BA, et al.
…rity were male, 980 (59.04%), Human Immunodeficiency Virus (HIV) negative status, 1295 (80.24%), diagnosed with smear, 1141 (73.14%), treated in private not-for-profit (PNFP) hospital, 1097 (66.08%), treated for TB between 2014-2016 (18.96%-19.52%). In multivariate analysis, age>…
Rockwood N, Cerrone M, Barber M, Hill AM, Pozniak AL
…n its pharmacokinetic and toxicity profile, particularly in HIV co-infected patients on combined antiretroviral therapy (cART). In this commentary, we evaluate evidence supporting increased global use of rifabutin and highlight key recommendations for action. Discussion Although …
Timire C, Ngwenya M, Chirenda J, Metcalfe JZ, Kranzer K, et al.
… (6%) DR-TB patients. Thirty-five (72%) DR-TB patients were HIV co-infected. Overall, 80% (95% CI: 77-82) of TB patients and their households experienced catastrophic costs. The major cost driver pre-TB diagnosis was direct medical costs. Nutritional supplements were the major co…
Kim Y, Kim SP, Han S
…nly reported in patients with human immunodeficiency virus (HIV). However, a similar reaction to anti-TB therapy can also occur in patients without HIV, especially in patients who have undergone solid organ transplantation. A 65-year-old woman who underwent kidney transplantation…
Finlayson H, Lishman J, Palmer M
…s 'rule-in' tests for children with presumed TB living with HIV. Treatment decision algorithms can be used to diagnose TB in symptomatic children in settings with and without access to chest X-rays; bacteriological confirmation should always be attempted. Summary Recent guideline…
Siamisang K, Rankgoane-Pono G, Madisa TM, Mudiayi TK, Tlhakanelo JT, et al.
…male patients. Of the extracted data, 1,366 (22.8%) were of HIV positive patients and 2,966 (49.4%) were of HIV negative patients. The rest of the data were of patients with unknown HIV status. Pulmonary TB accounted for 4,701 (78.3%) of the cases. Overall, 5,591 (93.1%) of the p…
Saadick Mugerwa Ssentongo, Bonniface Oryokot, Ronald Opito, Gerald Ochieng, Peter Sekiranda, et al.
…t completion), which stands at 89.1% for people living with HIV and 91.2% for those without HIV. The Teso region, one of the high TB burden regions in the country, has consistently had a lower treatment success rate (TSR). **OBJECTIVES:** To determine the treatment success and a…