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Inbaraj LR, Manesh A, Ponnuraja C, Bhaskar A, Srinivasalu VA, et al.
… up for 1 year after the treatment. DISCUSSION: Current WHO regimens have agents with poor central nervous system drug exposure and is too long. It does not reflect the accumulating evidence in the field. We propose a comprehensive clinical trial incorporating the emerging eviden…
Xinxin Zeng, Hao Xu, Aole Li, Juanjuan Liu, Yuhang Wu, et al.
…for childhood tuberculosis (TB), evaluation of TB treatment regimens for children in real-world settings in China remained limited, particularly regarding treatment duration, utilization of second-line anti-TB drugs (SLDs), and adverse events. This study aimed to describe the tre…
Sulis G, Tavaziva G, Gore G, Benedetti A, Solomons R, et al.
…mide (2HRZE/10HR). The comparative effectiveness of shorter regimens is unknown. Methods To inform a WHO guideline update, we undertook a systematic review and meta-analysis to evaluate outcomes from regimens of 6- to less than 12-months' duration that included, at a minimum, iso…
Susanna Esposito, Valentina Fainardi, Beatrice Rita Campana, Gaia Giorgia Arnesano, Nicola Principi
…16 years with drug-susceptible TB treated with short-course regimens compared to standard therapy.A shorter treatment regimen, particularly 4-month courses, has been investigated as an alternative to standard therapy in the pediatric population with drug-susceptible TB. Children …
Wasmann RE, Masini T, Viney K, Verkuijl S, Brands A, et al.
Following infection with Mycobacterium tuberculosis , young children are at high risk of developing severe forms of tuberculosis (TB) disease, including TB meningitis (TBM), which is associated with significant morbidity and mortality. In 2022, the World Health Organization (WHO)…
Ruiz-Bedoya C, Mota F, Tucker E, Mahmud F, Erice C, et al.
Abstract Background TB meningitis is the most severe form of tuberculosis (TB), associated with high morbidity and mortality. High-dose rifampin (35mg/kg/day) is safe in adults and substantially improves the bactericidal activity of standard TB regimen. However, there is conflict…
Aryal A, Garg B, Mehta N, Shekhar S, Gupta V
…rity in the healing response achieved compared to treatment regimens of longer duration.
…quires prolonged treatment using less effective, more toxic regimens. Recent trials demonstrated that the all-oral six-month “BPaL” regimen, Bedaquiline, Pretomanid and Linezolid, is 90% effective. In these trials, linezolid-induced hematologic and neurologic toxicity was high us…
Xueyi Chen, Carlos E Ruiz-Gonzalez, Yuderleys Masias-Leon, Medha Singh, Charles A Peloquin, et al.
Tuberculous meningitis causes substantial mortality due to limited penetration of antibiotics to the central nervous system and excessive neuroinflammation. This study evaluated clofazimine as an adjunct to the standard first-line tuberculosis regimen, in a mouse model. Mice were…
Johan Benhard, Gentiane Monsel, Vincent Dubée, Patricia Pavese, Vero Rasoldier, et al.
**BACKGROUND:** Morbidity associated with central nervous system tuberculosis (CNS TB) remains high due to persistent inflammation despite standard-of-care (SOC) treatment, including antituberculosis therapy and corticosteroids. Tumor necrosis factor alpha (TNF-α) is a key …
Kumar RNH, Rao CR, Maradi R, Umakanth S, Sanju SVC, et al.
Aim The study aimed to determine the incidence of adverse drug reactions (ADRs) among newly diagnosed tuberculosis (TB) patients receiving daily drug regimen with fixed-dose combination treatment under the National Tuberculosis Elimination Program. Materials and methods A communi…
Saluja A, Vibha D, Pandit AK, Shukla G, Srivastava AK, et al.
Introduction Corticosteroids are used as adjunctive treatment in tuberculous meningitis (TBM). However, there is no universally accepted regimen, type, duration, or route of steroid administration. Methodology In a randomized open labelled pilot study, TBM patients were divided i…
Li Z, Wang S, Chen X, Ming X, Peng L, et al.
Despite the high prevalence of pulmonary tuberculosis worldwide, extrapulmonary tuberculosis especially cutaneous and osteoarticular tuberculosis occurs rarely, both of which are often difficult to be recognized since their symptoms mimic those of many other cutaneous and osteoar…
Radisic MV, Pujato NR, Bravo PM, Del Grosso RC, Hunter M, et al.
…rom other populations or observational. Rifampin-containing regimens have strong pharmacokinetic interactions with immunosuppressive regimens, with high rates of organ dysfunction and ∼20% mortality. This report describes the results obtained using non-rifampin-containing regimen…
Xueyi Chen, Carlos E Ruiz-Gonzalez, Yuderleys Masias-Leon, Medha Singh, Oscar J Nino-Meza, et al.
…men, and retrospective studies showing that rifabutin-based regimens are effective and well-tolerated, both drugs still need dedicated evaluation in TB meningitis. **METHODS:** Mice were intracranially inoculated with Mycobacterium tuberculosis and treated with rifamycin (rifamp…
Xinxin Zeng, Hao Yao, Aole Li, Fei Wang, Juanjuan Liu, et al.
…ytical cohort. Clinical data, including detailed medication regimens, dosages, treatment durations, and adverse events, were collected. **RESULTS:** Of all included children, about a quarter were diagnosed with extrapulmonary TB. The dosage and duration of PZA often did not alig…
Akhmad Imron, Yulius Hermanto, Timotius Wira Yudha, Ahmad Rizal, Vycke Yunivita Kusumah Dewi, et al.
…erculosis therapy for TBM, focusing on optimizing treatment regimens. **METHODS:** This literature review primarily draws from studies available in the PubMed and Scopus databases on TBM regimens, focusing on publications that evaluate higher doses or novel drug therapies. Key s…
Rizvi I, Malhotra HS, Garg RK, Kumar N, Uniyal R, et al.
…iew summarizes the effects of fluoroquinolone in first line regimens in tuberculous meningitis. Methods A systematic search of literature was performed using PubMed, Cochrane Central Register of Controlled Trials (CENTRAL) and LILACS for articles published till march 2017. We als…
Pranger AD, van der Werf TS, Kosterink JGW, Alffenaar JWC
…ination. Simplified, shorter and preferably less toxic drug regimens are being investigated for pulmonary TB to counteract emergence of drug resistance. Intensified regimens with high-dose anti-TB drugs during the first weeks of treatment are being investigated for TB meningitis …
Ruth A Howe, Binayak Rimal, Jay Khandelwal, Chandra Panthi, Gyanu Lamichhane
…ntibiotics, modeled after tuberculosis treatment, but these regimens are limited by toxicity, poor adherence, and low cure rates. Importantly, unlike,is acquired from the environment rather than transmitted between humans, weakening the rationale for multidrug therapy as a strate…
Ruth A Howe, Binayak Rimal, Jay Khandelwal, Chandra M Panthi, Gyanu Lamichhane
…ntibiotics, modeled after tuberculosis treatment, but these regimens are limited by toxicity, poor adherence, and low cure rates. Importantly, unlike M. tuberculosis, M. avium is acquired from the environment rather than transmitted between humans, weakening the rationale for mul…
Lanni F, Antilus Sainte R, Hansen M Jr, Parigi P, Kaya F, et al.
…M would also be of great value to prioritize promising drug regimens to be tested in clinical trials, given the healthy state of the development pipeline for the first time in decades. Here, we report the optimization of a rabbit model of TBM disease induced via inoculation of My…
Dian S, Ganiem AR, Te Brake LH, van Laarhoven A
… tools and ongoing research aimed at improving TB treatment regimens, the mortality rate for neurotuberculosis remains high. While antituberculosis drugs were discovered in the 1940s, TB treatment regimens were designed for and studied in pulmonary TB and remained largely unchang…
Misra UK, Kumar M, Kalita J
…ing the inclusion criteria were randomized to four drug ATT regimens (rifampicin, isoniazid, ethambutol and pyrazinamide) administered either simultaneously (standard arm) or one after another (sequential arm) in a 1 : 1 ratio. The primary endpoint was drug-induced hepatitis (DIH…
Ding J, Thuy Thuong Thuong N, Pham TV, Heemskerk D, Pouplin T, et al.
The most effective antituberculosis drug treatment regimen for tuberculous meningitis is uncertain. We conducted a randomized controlled trial comparing standard treatment with a regimen intensified by rifampin 15 mg/kg and levofloxacin for the first 60 days. The intensified regi…