Showing 1–25 of 82 documents
Sorted by hybrid relevance (keyword + semantic via RRF)
Walles J, Winqvist N, Hansson SR, Sturegård E, Baqir H, et al.
…ckground Tuberculosis (TB) disease has been associated with pregnancy complications. However, the potential impact of TB infection (TBI) on pregnancy outcome is unknown. To investigate this, we conducted a register-based study in immigrant women screened with QuantiFERON assays f…
Tesfaye F, Sturegård E, Walles J, Bekele B, Bobosha K, et al.
…ntrol of tuberculosis (TB) infection could be influenced by pregnancy. To elucidate this, we longitudinally characterized Mycobacterium tuberculosis (Mtb)-specific and nonspecific immune responses in women during pregnancy and postpartum. HIV-uninfected women without past or curr…
Amaeze OU, Isoherranen N
Pregnancy can increase the risk of latent tuberculosis infection (LTBI) progression to tuberculosis (TB) disease. Isoniazid (INH) is the preferred preventative treatment for LTBI in pregnancy. INH is mainly cleared by N-acetyltransferase 2 (NAT2) but the pharmacokinetics (PK) of …
Moro RN, Scott NA, Vernon A, Tepper NK, Goldberg SV, et al.
…ine (P, 900 mg) (3HP) for latent infection treatment during pregnancy. Objectives To assess safety and pregnancy outcomes among pregnant women who were inadvertently exposed to study medications in two latent tuberculosis infection trials (PREVENT TB or iAdhere) evaluating 3HP an…
Wang K, Ren D, Qiu Z, Li W
Background Pregnancy complicated with tuberculosis is increasingly common. The clinical characteristics of pregnancy complicated with miliary tuberculosis are summarized in this study. Methods A retrospective analysis of pregnant patients with miliary tuberculosis was performed i…
Saha A, Escuduero J, Layouni T, Richardson B, Hou S, et al.
Background Pregnancy is a risk factor for progression from latent tuberculosis infection to symptomatic tuberculosis. However, how pregnancy influences T-cell responses to Mycobacterium tuberculosis is unknown. Methods We measured M. tuberculosis-specific cytokines, T-cell memory…
Xiaobing Yang, Haitian Chen, Xiangyi Kong, Taisheng Lai, Hailong Liang, et al.
…nfertility, yet its effects on ovarian reserve function and pregnancy outcomes in women undergoing assisted reproductive technology (ART) remain unclear. This study aimed to investigate the impact of LTBI on ovarian reserve and clinical pregnancy outcomes in infertile women treat…
Birku M, Desalegn G, Kassa G, Tsegaye A, Abebe M
Objective To investigate the effect of pregnancy and Human immunodeficiency virus (HIV) infection on detection performances of tuberculin skin test (TST) and QuantiFERON-TB Gold In-Tube (QFTGIT) for the diagnosis of latent tuberculosis infection (LTBI) among women living in high …
Singh P, Moulton LH, Barnes GL, Gupta A, Msandiwa R, et al.
…recommended for people with HIV infection, including during pregnancy. The effect of TPT exposure at conception and during pregnancy is poorly documented. Methods We report pregnancy outcomes among South African women with HIV enrolled in a randomized trial of 4 TPT regimens (two…
Weinberg A, Aaron L, Montepiedra G, Sterling TR, Browning R, et al.
Background Pregnancy is accompanied by immune suppression. We hypothesized that Mycobacterium tuberculosis-specific inflammatory responses used to identify latent tuberculosis infection (LTBI) lose positivity during pregnancy. We also hypothesized that isoniazid preventive therap…
Wolf B, Krasselt M, de Fallois J, von Braun A, Stepan H
In recent years, the incidence of tuberculosis in pregnancy in the industrialised countries has increased. Tuberculosis in pregnancy is associated with an increased risk for the mother and child. Even if no figures are available for Germany, an increase in the number of tuberculo…
Birku M, Desalegn G, Kassa G, Tegbaru B, Howe R, et al.
…infection and this suppression could further be enhanced by pregnancy. However, the effect of pregnancy on Mycobacterium tuberculosis (M. tuberculosis)-specific immune response during HIV/latent TB co-infection is not well understood. Here we investigated the changes in M. tuberc…
Liu K, Zhang X, Ma X, Jia X, Zhao X, et al.
…though female genital tuberculosis may lead to infertility, pregnancy is still possible, especially through in vitro fertilization (IVF). In this eventuality, even latent tuberculosis (TB) infection is prone to reactivate. Because some of the symptoms of TB overlap with those of …
Mendiratta V, Yadav A
Pregnancy with systemic lupus erythematosus (SLE) requires special attention in view of the enhanced risks to the fetus and the aggravation of SLE during pregnancy. Human immunodeficiency virus infection can further complicate the course of pregnancy as well as the outcome. We pr…
Chu Y, Chen Y, Yao W, Wang L, Zhang B, et al.
…lity, and whether LTBI would affect the ovarian reserve and pregnancy outcome of infertile women undergoing intrauterine insemination (IUI) is still unknown. A single-center, retrospective, cohort study was designed that included infertile women undergoing IUI at the Department o…
Masood U, Venturini N, Nicoletti P, Dellinger A, Kleiner D, et al.
…r Injury Network between 2004 and 2022 and occurring during pregnancy or 6 months postpartum were reviewed and compared with cases of drug-induced liver injury in nonpregnant women of childbearing age. Among 325 individuals of childbearing age in the Drug-Induced Liver Injury Net…
Tesfaye F, Walles J, Sturegård E, Winqvist N, Balcha TT, et al.
Pregnancy may influence cellular immune responses to Mycobacterium tuberculosis. We investigated M. tuberculosis-specific interferon-γ responses in women followed longitudinally during pregnancy and postpartum. Interferon-γ levels (stimulated by M. tuberculosis antigens [TB1 and …
Modi P, Khanna R, Reddy N, Patankar A, Patel S, et al.
…management for COVID-19 and pulmonary tuberculosis (PTB) in pregnancy. However, to the best of our knowledge, there are no significant guidelines for the management of COVID-19 and PTB co-infection in pregnancy. Pregnancy being an altered physiological state, the use of various d…
Gai X, Chi H, Zeng L, Cao W, Chen L, et al.
… study, we aim to analyze the relationship between LTBI and pregnancy outcomes following IVF-ET in patients with untreated prior PTB. Methods and Analysis: We designed a prospective cohort study of 1,200 infertile women with CXR findings suggestive of old-healed untreated TB, who…
Jia X, Wei L, Zhang N, Zheng B, Li M, et al.
…aimed to analyze the relationship between LTBI and clinical pregnancy outcomes of IVF and fresh embryo transfer (IVF-FET). This was a retrospective study of 628 infertile women who had undergone IVF-FET in the Fourth Affiliated Hospital of Hebei Medical University from January 20…
Cao W, Fu X, Li H, Bei J, Li L, et al.
…echnology to conceive. Latent tuberculosis infection during pregnancy has no clinical manifestation, but may develop into active tuberculosis, leading to adverse pregnancy outcomes. Most pregnant women do not need to be treated for latent tuberculosis infection, unless they are c…
Felix Bongomin, Phillip Ssekamatte, Ronald Olum, Diana Sitenda, Davis Kibirige, et al.
**BACKGROUND:** Pregnancy modulates immune responses against() infection. Cytokines, including interleukin-2 (IL-2), play a crucial role incontainment, mainly by inducing the proliferation of T cells. However, the role of IL-2 in latent tuberculosis (TB) infection (LTBI) screenin…
Miele K, Bamrah Morris S, Tepper NK
Tuberculosis (TB) in pregnancy poses a substantial risk of morbidity to both the pregnant woman and the fetus if not diagnosed and treated in a timely manner. Assessing the risk of having Mycobacterium tuberculosis infection is essential to determining when further evaluation sho…
Bhosale R, Alexander M, Deshpande P, Kulkarni V, Gupte N, et al.
… among women with and without HIV respectively. Conclusions Pregnancy affects TBI test results and reduces IFN-γ response to M. tuberculosis stimulation. Despite adequate CD4 counts, women with HIV express less IFN-γ than women without HIV, which may explain the high TB incidence…
Kaplan S, Matemo D, Mecha J, Kinuthia J, John-Stewart G, et al.
Abstract Background Pregnancy and HIV-associated immunologic changes may affect latent TB infection (LTBI) interferon-gamma release assay (IGRA) QuantiFERON TB Gold Plus (QFT-Plus) diagnostic performance. Methods In this ongoing study, HIV-infected and -uninfected women 20–34 wee…