Showing 1–25 of 37 documents
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Shruti Kaushal, Sunil Kumar Dhatwalia, Rakesh Yadav, Sumedha Sharma, Pankaj C Vaidya, et al.
…ra), as first-line diagnostic tests for detecting pulmonary tuberculosis (PTB) and rifampicin resistance in children suspected of having the disease. Respiratory specimens (gastric lavage/bronchoalveolar lavage/sputum/endotracheal aspirate) obtained from 116 children with presump…
Torane VP, Nataraj G, Kanade S, Deshmukh CT
…objective Global TB report 2021 mentions 11 % prevalence of pediatric TB, whereas 5.65% of the cases were reported from India in 2020. India features in the list of TB high burden countries, HIV-TB high burden and MDR-TB high burden countries. The diagnosis of pulmonary tuberculo…
Geweniger A, Janda A, Eder K, Fressle R, Kannan CV, et al.
Background The microbiological diagnosis of pulmonary tuberculosis (Tb) in a pediatric population is hampered by both low pathogen burden and noncompliance with sputum sampling. Although endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) has been found u…
Daniel Mashiach, Justin Shon, Raquel Mashiach, Gregory Ayzenberg, Osnat Barazani, et al.
Pediatric tuberculosis (TB) remains a critically underrecognized contributor to global childhood morbidity and mortality, with the highest burden concentrated in low-resource settings. Although children comprise a minority of overall TB cases, mortality is disproportionately high…
Abstract BACKGROUND Tuberculosis (TB) is a rare but potentially devastating infection among Canadian children. Accurate diagnosis and initiation of treatment are limited in part by the fact that it takes 2–6 weeks for culture results to be confirmed. Xpert MTB/RIF (Xpert) is a ra…
Katherine Laycock, Karl-Günter Technau, Patricia Lelo, Watsamon Jantarabenjakul, Caroline Yonaba, et al.
**BACKGROUND:** Tuberculosis (TB) remains a leading cause of morbidity and mortality for children living with HIV (CLHIV), with gaps in TB screening, diagnostics, management, and TB preventive therapy (TPT). We investigated reported practices in these domains at sites caring for …
Imperiale BR, Nieves C, Mancino B, Sanjurjo M, Tártara S, et al.
…re is a critical need to improve the diagnostic accuracy of tuberculosis (TB) in children. Several techniques have been developed to improve the quality of sputum samples; however, these procedures are very unpleasant and invasive and require hospitalization and trained personnel…
K S S, Saldanha PRM, Kushwah S, Prabhu AS
Introduction In spite of having BCG vaccination and tuberculosis control program for the last 50 years, prevalence of tuberculosis continues to be high in India. Inadequate diagnostic methods, suboptimal treatment and monitoring, and the lack of vigilant reporting system are some…
Chiang SS, Sheremeta Y, Padilla RS, Jenkins HE, Horsburgh CR Jr, et al.
Few reports have described pediatric Multidrug-resistant Tuberculosis (MDR-TB) in the former Soviet republics, despite the fact that these countries have the highest proportion of TB cases that are MDR. We aimed to examine pediatric MDR-TB in Ukraine. This retrospective cohort st…
Hoffman CJ, France T, Cram T, Bodmer JL, Sanders JS
…minated disease in this case. We review the difficulties in diagnosis and treatment of pediatric MDR-TB.
Jouego CG, Agbor VN, Noeske J, Manuel NA, Ayuk LN
Background Tuberculosis remains a major cause of morbidity and mortality worldwide, especially in developing countries. The diagnosis and treatment of multi-drug resistant tuberculosis (MDR-TB) in children remain a major limitation in this setting, largely due to difficulties in …
Gaensbauer JT, Dash N, Verma S, Hall DJ, Adler-Shohet FC, et al.
Pediatric multidrug-resistant tuberculosis (MDR-TB) remains a significant global problem, and there are numerous barriers preventing children with MDR-TB from being identified, confirmed with microbiologic tests, and treated with a safe, practical, and effective regimen. However,…
Misra S, Misra N, Seepamore B, Holloway K, Singh N, et al.
…he experiences of children being treated for drug-resistant tuberculosis (DR-TB), and most work in the area has been done with older children and adolescents. Comprehensive explorations of the caregiver experiences in this area are also lacking. Objective To describe the experien…
Schäfer HL, Barker M, Follmann P, Günther A, Hörning A, et al.
Delay in diagnosing multidrug-resistant tuberculosis (MDR-pTB) in children prolongs time to effective treatment. Data on risk factors for pediatric MDR from low-incidence countries are scarce. Retrospective nationwide case-control study to analyze MDR-pTB cases in Germany between…
Epperson K, Crane C, Ingulli E
Donor derived infections (DDIs) in pediatric kidney transplant recipients remain challenging to diagnose and can result in serious morbidity and mortality. This review summarizes the current guidelines and recommendations for prevention, diagnosis, and treatment of unexpected DDI…
Dong-Mei Wang, Qi An, Qing Yang, Yi Liao
…To describe the demographic and clinical characteristics of pediatric tuberculosis (TB) inpatients diagnosed with resistance to any anti-tuberculosis drug [drug-resistant tuberculosis (DR-TB)] in southwest China. **METHODS:** Patients aged ≤14 years with clinically…
Zhang Y, Zhao R, Zhang Z, Liu Q, Zhang A, et al.
Objective Pediatric tuberculosis (TB) is one of the top ten causes of death in children. Our study was to analyze influencing factors of multidrug-resistant tuberculosis (MDR-TB) and validation of whole-genome sequencing (WGS) used in children with drug-resistant TB (DR-TB). Meth…
Schaaf HS
…oximately 25,000 children develop multidrug-resistant (MDR) tuberculosis (TB) each year, but few of them are diagnosed and appropriately treated for MDR-TB. New diagnostic tools have improved our ability to diagnose children with bacteriologically confirmed TB earlier. However, t…
Roya-Pabón C, Restrepo A, Morales O, Arango C, Maya MA, et al.
Tuberculosis (TB) in the pediatric population is a major challenge. Our objective was to describe the clinical and microbiological characteristics, radiological patterns, and treatment outcomes of children and adolescents (from 1 month to 17 years) with community-acquired pneumon…
Singh UB, Verma Y, Jain R, Mukherjee A, Gautam H, et al.
Diagnosis of intra-thoracic tuberculosis (ITTB) in children is difficult due to the paucibacillary nature of the disease, the challenge in collecting appropriate specimens, and the low sensitivity of smear microscopy and culture. Culture and Xpert MTB/RIF provide higher diagnosti…
Lhadon T, Jullien S
Multidrug-resistant tuberculosis (MDR-TB) is a well-identified raising public health concern worldwide. However, the data available on MDR-TB in children and particularly in the neonate age group are limited. Congenital tuberculosis (TB) is rare, and its diagnosis is challenging …
Park M, Owles H, Williams A, Williams B, Whittaker E, et al.
Tuberculosis (TB) is an important cause of childhood death and morbidity worldwide. The diagnosis in the pediatric population remains challenging due to the paucibacillary nature of the disease. Intrathoracic lymphadenopathy is one of the most common manifestations of primary dis…
Schaaf HS, Hughes J
Optimal diagnosis and management of children aged <15 y with rifampicin- or multidrug-resistant tuberculosis (RR/MDR-TB) relies on identification of adults with the disease and pro-active screening of their close contacts. Children may be diagnosed with RR/MDR-TB based on microbi…
Bangarwa M, Dhingra D, Mittal M, Saigal K, Ghosh A
…ry in the world with almost 27 lakh cases reported in 2019. Pediatric tuberculosis in India accounts for almost 31% of global TB burden. Despite such high mortality and morbidity in children, diagnosis of pulmonary TB in children still remains very challenging. Material and metho…
Sekarsari D, Handoyono QF, Amal MY, Maharani MAP, Hendriarto A
…ling a history of contact with parental multidrug-resistant tuberculosis. Multimodality radiological examinations, including conventional radiography, CT, and MRI revealed extensive disease of the spine with disc involvement, large paravertebral abscess, and kyphotic deformity wh…