Showing 1–25 of 64 documents
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Gaensbauer J, Broadhurst R
Purpose of review Tuberculosis is leading cause of global morbidity and mortality and a significant proportion of the burden of disease occurs in children. In the past 5 years, a number of innovations have improved the diagnosis and treatment for children with both latent tubercu…
Ghanaie RM, Karimi A, Azimi L, James S, Nasehi M, et al.
… Although the World Health Organization has recommended the diagnosis and prophylactic treatment of latent tuberculous infection (LTBI) in child household contacts of tuberculosis (TB) cases, the national programs in high-burden TB regions rarely implement adequate screening of t…
Sayyahfar S, Davoodzadeh F, Hoseini R, Rahimzadeh N, Otukesh H
…till a valuable diagnostic tool with high accuracy rate for diagnosis of LTBI in children candidates for renal transplantation and can still be used as an accurate test for screening Mycobacterium TB infection.
Druszczynska M, Seweryn M, Wawrocki S, Pankowska A, Kulbachko A, et al.
Background Accurate diagnosis of tuberculosis (TB) in children continues to be challenging, primarily due to the low bacterial load characteristic of the disease and the obstacles in collecting sputum samples. Furthermore, detecting cases of latent Mycobacterium tuberculosis (M.t…
Kanjanaphan T
Background Tuberculosis (TB) is an important public health problem, and airborne transmission is easily transmitted. Latent TB infection (LTBI) detection and treatment is the key strategy to prevent TB. Objective This study aimed to perform contact investigation of LTBI in health…
Mase A, Ryan S, Mader G, Alvarez A, Armitige L, et al.
…or Disease Control and Prevention (CDC) funds five Regional Tuberculosis Training and Medical Consultation Centers (RTMCCs) that provide training and consultation for tuberculosis (TB) control and management. RTMCC utilization for assistance with diagnosis and management of TB in…
Ma HW, Lee HS, Ahn JY
The incidence of tuberculosis remains high in South Korea; the management of latent tuberculosis infection (LTBI) has become the prime target for reducing the infection rate. The management of pediatric LTBI is especially crucial because children can serve as a long-term source o…
Cai Q, Shen X, Li H, Yao C, Sun N, et al.
Background Mycobacterium tuberculosis (Mtb)-specific perforin were significantly increased in patients with tuberculosis. This study aims to evaluate the diagnosis value of Mtb-specific perforin in pediatric patients with tuberculosis. Methods Diagnostic performance of perforin l…
Adusumelli Y, Tabatneck M, Sherman S, Lamb G, Sabharwal V, et al.
…00 US children and adolescents are estimated to have latent tuberculosis (TB) infection. Identifying facilitators and barriers to engaging in TB infection care is critical to preventing pediatric TB disease. We explored families' and clinicians' perspectives on pediatric TB infec…
Nadege Nziza, Wonyeong Jung, Tina Chen, Yixiang Deng, Kees L M C Franken, et al.
**BACKGROUND:** Tuberculosis (TB), caused by(Mtb), is among the leading causes of death from an infectious agent among children worldwide. Children represent a particularly vulnerable population due to the greater challenges in diagnosis and the higher risk of progression to seve…
…ackground Understanding barriers and facilitators to latent tuberculosis infection (LTBI) diagnosis and care is needed to successfully treat children/adolescents with LTBI in the US. We explored physicians’ perspectives on pediatric LTBI diagnosis and care, and strategies to impr…
Ndzi EN, Nkenfou CN, Mekue LM, Zentilin L, Tamgue O, et al.
The diagnosis of tuberculosis (TB) continues to pose substantial public health problems. The quest for diagnostic biomarkers for TB is therefore primordial. This study aimed to evaluate the diagnostic and anti-TB treatment monitoring potentials of some selected miRNAs. Quantitati…
Nordholm AC, Holden IK, Hartling UB, Andersen PH, Lillbaek T, et al.
Background In Western Europe, most pediatric tuberculosis (TB) cases occur among immigrants; however, data are rarely stratified by first/second-generation immigrants and many cases may be preventable. Methods This was a nationwide study of children Results We identified 145 case…
Starshinova A, Zhuravlev V, Dovgaluk I, Panteleev A, Manina V, et al.
Background The WHO strategy for eradication of tuberculosis (TB) by 2035 (The End TB Strategy) is aimed at an early and precise diagnosis and subsequent effective treatment of TB patients. Currently, there is no gold standard for the diagnosis of latent TB infection. This study e…
Jia J, Chen D, Liu L, Siddiqui MJ, Yang F, et al.
Background China has a high burden of tuberculosis and latent tuberculosis infection (LTBI). The aim of this study was to estimate the prevalence of LTBI among healthy young children and adolescents and test a 2-step approach to explore the threshold for the diagnosis of tubercul…
Campbell J, Sandora T, Haberer J
… estimated 1 million children develop and ~200,000 die from tuberculosis (TB). The WHO has named identification and treatment of latent tuberculosis infection (LTBI) one of the cornerstones of efforts to eliminate TB by 2030. Identification and treatment of pediatric LTBI require…
Wendorf KA, Lowenthal P, Feraud J, Cabanting N, Murto C
…nterferon-γ release assays (IGRAs) in children ≥2 years for diagnosis of latent tuberculosis infection (LTBI). However, lack of experience in young children and concern that IGRAs are less sensitive than tuberculin skin tests (TSTs) limit their use. Our aim was to identify active…
Carvalho ACC, da Silva Martins P, Cardoso CAA, Miceli AL, Martire T, et al.
…acteristics, diagnostic approach, and treatment outcomes of tuberculosis (TB) in children living in a high-burden metropolitan area. Methods This was a retrospective study, based on a medical chart review, involving children under 15 years old treated for TB between 2007 and 2016…
Brinkmann F, Hofgrefe J, Ahrens F, Weidemann J, Berthold LD, et al.
Background The differentiation between latent tuberculosis infection (LTBI) and tuberculosis (TB) relies on radiological changes. Confirming the diagnosis remains a challenge because typical findings are often missing in children. This study evaluates diagnostic sensitivity, spec…
Magdalena D, Michal S, Marta S, Magdalena KP, Anna P, et al.
Profound tuberculosis (TB)-induced metabolic changes reflected in the blood metabolomic profile may provide an opportunity to identify specific markers of Mycobacterium tuberculosis infection. Using targeted liquid chromatography tandem mass spectrometry, we compared the levels o…
Wattal C, Raveendran R
The diagnosis of childhood tuberculosis is a challenge due to the pauci-bacillary nature of infection and the difficulty in obtaining appropriate sample. In the past 2-3 decades, many new tests were introduced for the diagnosis of tuberculosis (TB) and some of them have been eval…
Böncüoğlu E, Kıymet E, Şahinkaya Ş, Akaslan Kara A, Çağlar İ, et al.
…antiFERON®-TB Gold Plus) and tuberculin skin test (TST) for tuberculosis infection were included in the study. Underlying medical conditions of the patients were recorded. Cohen's κ was run to determine if there was an agreement between TST and IGRA. Results A total of 220 patien…
Said K, Hella J, Ruzegea M, Solanki R, Chiryamkubi M, et al.
Background Childhood tuberculosis (TB) is acquired after exposure to an infectious TB case, often within the household. We prospectively screened children 6-59 months of age, exposed and unexposed to an infectious TB case within the same household, for latent tuberculosis infecti…
Shyamkumar Sriram, Tareq Abualfaraj, Manal Ali Alsharif, Marwa Zalat, Saad Madani Alawfi, et al.
Patients with latent tuberculosis infection are mainly asymptomatic, but they still carry a notable risk of developing active TB, particularly when the host becomes immunosuppressed. Hence, appropriate diagnosis and management for LTBI are essential. Tuberculin skin test (TST) an…
Kushner L, Mony V, Vu D
…ckground For foreign-born children from countries with high tuberculosis (TB) burden, positive tuberculin skin test (TST) results, associated with Bacillus Calmette Guerin (BCG) vaccination, paradoxically increase the risk for overdiagnosis and overtreatment of latent TB infectio…