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Cuadros EN, Calzada-Hernández J, Clemente D, Martín SG, Silveira LF, et al.
…rovides practical recommendations on infection screening in pediatric patients with immune-mediated rheumatic diseases and immunosuppressive therapies. For this reason, a qualitative approach was applied. A narrative literature review was performed via Medline. Primary searches w…
Brendan Mullen, Joy Githua, Jaclyn N Escudero, Jerphason Mecha, Lucy Kijaro, et al.
…lescents worldwide. Diagnostic challenges are pronounced in pediatrics, in which collecting respiratory specimens is challenging and TB is often paucibacillary, leading to delayed diagnosis and increased mortality. We describe the protocol and methodology of the Pediatric TB Diag…
Lee WS, Arai K, Alex G, Treepongkaruna S, Kim KM, et al.
Disease phenotype of pediatric inflammatory bowel disease (PIBD) in children from the Asia-Pacific region differs from that of children from the West. Many parts of Asia are endemic for tuberculosis, making diagnosis and management of pediatric Crohn's disease a challenge. Curren…
Lee WS, Arai K, Alex G, Treepongkaruna S, Kim KM, et al.
Pediatric inflammatory bowel disease (PIBD) is rising rapidly in many industrialised and affluent areas in the Asia Pacific region. Current available guidelines, mainly from Europe and North America, may not be completely applicable to clinicians caring for children with PIBD in …
Olbrich L, Nliwasa M, Sabi I, Ntinginya NE, Khosa C, et al.
…perfect reference standard, Rapid and Accurate Diagnosis of Pediatric Tuberculosis Disease (RaPaed-TB) was designed following a rigorous and complex methodology. This allows for the determination of diagnostic accuracy of novel assays and combination of testing strategies for opt…
Clemente Garulo D, Núñez-Cuadros E, Camacho Lovillo M, Calzada-Hernández J, Guillén Martín S, et al.
…e practical recommendations on prophylaxis for infection in pediatric patients with immune-mediated rheumatic diseases receiving/scheduled to receive immunosuppressive therapy. A qualitative approach was applied. A narrative literature review was performed via Medline. Primary se…
Clemente D, Cuadros EN, Lovillo MC, Hernández JC, Martín SG, et al.
…s to provide practical recommendations on the management of pediatric patients with immune-mediated rheumatic diseases receiving immunosuppressive therapies. The recommendations specifically address the cases of surgery, fever, and opportunistic infections (varicella, herpes-zost…
James Marcomic Maragia, Jepchirchir Kiplagat, Onyango Dickens, Lazarus Odeny, Stephen Olubulyera, et al.
…nya, approximately 77,000 TB cases were reported, with pediatric TB contributing to 9.6% of all cases and 4.8% of TB-related deaths. Turkana County, a pastoralist region, accounted for 19% of the national pediatric TB burden. The specific drivers of this high pediatric TB ra…
Sangeeta Kumari, Aarti Agarwal, Manveer Singh, Komal Grover, Jagdish Chandra, et al.
…atment (TPT) in India remains suboptimal, especially in the pediatric age group. This study aimed to determine the missed opportunities of disease identification and prevention among pediatric TB cases with a documented history of household exposure to a TB index case. Prima…
Vukugah TA, Akoku DA, Tchoupa MM, Lambert E
…ttitude, and practice (KAP) of healthcare workers (HCWs) on pediatric TB management and its associated factors in the Centre Region of Cameroon. Methods A cross-sectional study was conducted between January and March 2022. HCWs, selected through a multistage sampling technique in…
Beyer RS, Franklin AJ, Hatter MJ, Nguyen A, Brown NJ, et al.
…re characterized by inflammation of the endplate-disc unit. Pediatric spinal infection is rare and challenging to diagnose due to vague presenting symptoms. Most cases are conservatively managed with surgery rarely indicated. The authors performed a systematic review to study the…
Matthew Willis, Joelle Van de Wetering, Heynes Brown, Ewelina Julia Barnowska, Sophie Cw Stuetzle, et al.
**BACKGROUND:** Pediatric tuberculosis (TB) is a significant public health concern in India, contributing to 28% of the global pediatric TB burden. Despite its impact on child health, strategies to control TB have inadequately addressed pediatric cases, resulting in suboptimal ma…
Earley M, Chirenda J, Highet A, Mujuru HA, Yang Z
Pediatric tuberculosis (TB) represents a major barrier to reducing global TB mortality, especially in countries confronting dual TB and human immunodeficiency virus (HIV) epidemics. Our study aimed to characterize pediatric TB epidemiology in the high-burden setting of Harare, Zi…
Van Brusselen D, Simons E, Luendo T, Habarugira D, Ngowa J, et al.
… covering a population of 520,000, with an elevated rate of pediatric malnutrition. In July 2017, an adapted MSF pediatric TB diagnostic algorithm, including Xpert MTB/RIF on gastric aspirates (GAs), was implemented. The aim of this study was to evaluate whether the introduction …
Mandera I, Ayebazibwe G, Tumusiime A, Byamukama T, Mfitumukiza V, et al.
…rculosis (TB) and >214,000 died in 2022. The integration of pediatric TB screening should help in the identification and management of cases among children attending clinics at entry points. This study aimed to establish the extent of integrating pediatric TB screening into mains…
Siddalingaiah N, Chawla K, Nagaraja SB, Hazra D
Pediatric tuberculosis is a major cause of mortality and morbidity in children due to high transmission, poor diagnostic tools, and various respiratory diseases mimicking TB. Identifying risk factors will provide evidence for clinicians to strongly relate their diagnosis to the a…
Harrist AV, McDaniel CJ, Wortham JM, Althomsons SP
Introduction Pediatric tuberculosis (TB) cases are sentinel events for Mycobacterium tuberculosis transmission in communities because children, by definition, must have been infected relatively recently. However, these events are not consistently identified by genotype-dependent …
Alicia Hernanz-Lobo, Juan J Gómez-Valverde, Ángel Lancharro, Ramón Sánchez-Jacob, José Luis Ribó, et al.
…t radiography (CXR) is the most widely used imaging tool in pediatric tuberculosis (TB) diagnostic pathways, and remains central in current WHO algorithms. However, its standalone diagnostic accuracy has not been well established in standardized multicenter evaluations. This stud…
Weldetsadik AY, Abayneh M, Abraha M, Sirgu S, Bekele D
Introduction Most previous pediatric COVID-19 studies reported milder disease in children. However, there are limited pediatric data from low-income settings. We aimed to assess the characteristics and outcomes of pediatric COVID-19 in Ethiopia. Setting St. Paul's COVID-19 treatm…
Marina Bahaa Monir Zakhary Gad El Sayed, Dennis Tai, Lucy Yu, Daniel Novak, Amrita Dosanjh
…tcomes of pulmonary NTM infections in a non-cystic fibrosis pediatric population from four distinct age groups. **METHODS:** A retrospective study as cross-sectional design for data collection from the TriNetX platform, a global electronic health record database. Inclusion crite…
Yang Yang, Dan Ye, Zhentao Fei, Ping Liu, Huarui Liu, et al.
**BACKGROUND:** Pediatric tuberculosis (TB) remains a major global health challenge, characterized by age-specific difficulties especially in diagnosis compared to adults. This review summarizes key advances in pediatric TB diagnostics over the past five years. **METHODS:** Lite…
Headriawan A, Pramono AA, Sukadi A, Chairulfatah A, Maskoen AM, et al.
Background As pediatric tuberculosis (TB) globally is still reported challenging in diagnosis, to date, a lot of efforts have been established to eliminate the disease including proper treatment regimen using anti-TB drugs. However, antituberculosis drug-induced hepatotoxicity (A…
Lyu M, Zhou J, Cheng Y, Chong W, Wu K, et al.
…ntify proper respiratory-related sample types for adult and pediatric pulmonary tuberculosis (PTB), respectively, by comparing performance of Xpert MTB/RIF when using bronchoalveolar lavage (BAL), induced sputum (IS), expectorated sputum (ES), nasopharyngeal aspirates (NPAs), and…
Xiaojun Wang, Cuili Yang, Meilan Zhou, Cuiping Xiao, Xiaolu Yu, et al.
**BACKGROUND:** Research on the economic burden of pediatric tuberculosis (TB) remains scarce. This study aims to investigate the hospitalization characteristics, direct medical expenses, and key determinants of hospitalization costs in pediatric TB patients. **METHODS:** We con…
Vukugah TA, Ntoh VN, Akoku DA, Leonie S, Jacob A
…o meet the specific needs of children is critical to ending pediatric TB epidemic. Systematic reviews are increasingly informing policies in pediatric tuberculosis (TB) care and control. However, there is a paucity of information on pediatric TB research priorities. Methodology .…