Showing 1–13 of 13 documents
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Siamisang K, Rankgoane-Pono G, Madisa TM, Mudiayi TK, Tlhakanelo JT, et al.
…duction Globally, the amount of research on the outcomes of pediatric tuberculosis (TB) is disproportionately less than that of adult TB. The diagnosis of paediatric TB is also problematic in developing countries. The aim of this study was to describe the outcomes of pediatric TB…
Denti P, Wasmann RE, van Rie A, Winckler J, Bekker A, et al.
…pyrazinamide 120/35/130 mg) to children Conclusions Current pediatric FDC doses resulted in low rifampicin exposures. Optimal dosing of all drugs cannot be achieved with the current FDCs. We propose a new FDC formulation and revised weight bands.
Dutta NK, Tornheim JA, Fukutani KF, Paradkar M, Tiburcio RT, et al.
Pediatric tuberculosis (TB) remains a major global health problem. Improved pediatric diagnostics using readily available biosources are urgently needed. We used liquid chromatography-mass spectrometry to analyze plasma metabolite profiles of Indian children with active TB (n = 1…
Tae Kyu Chung, Eunsol Yang, Maureen Shin, Belen P Solans, Xujia Zhou, et al.
… **CONCLUSION:** Our IPDMA supports the revision of current pediatric EMB dosing guidelines for the treatment of tuberculosis. Our findings aim to ensure adequate drug exposure across all pediatric weight bands, while also accounting for toxicity and challenges related to formula…
Qian Zhai, Xianglong Kong, Qian Li, Na Yang
… **METHODS:** In this prospective observational study, 235 pediatric pulmonary tuberculosis patients treated at Hebei Provincial Chest Hospital from February 2021 to February 2025 were enrolled. Based on drug-susceptibility testing, participants were classified into a drug-resis…
Apolisi I, Cox H, Tyeku N, Daniels J, Mathee S, et al.
…ment. Key factors supporting these outcomes included use of pediatric formulations for young children, monotherapy, and community-based options for assessment and follow up.
Yasobant S, Shah H, Bhavsar P, Patel J, Saha S, et al.
…uch as drug-sensitive TB (DSTB), drug resistance TB (DRTB), pediatric TB, and extra-pulmonary TB. It included both public and private sector patients. The study findings suggested that about 41% of pulmonary and 51% of extra-pulmonary patients reported total delay. Delay in initi…
Solans BP, Béranger A, Radtke K, Mohamed A, Mirzayev F, et al.
…ose with HIV are underexposed to RIF. Standardization of PK pediatric studies and individual patient data analysis with safety assessment are needed to inform optimal dosing.
Van Schalkwyk M, Bekker A, Decloedt E, Wang J, Theron GB, et al.
… (PK) of antituberculosis drugs. The International Maternal Pediatric Adolescent AIDS Clinical Trials Network P1026s was a multicenter, phase IV, observational, prospective PK and safety study of antiretroviral and antituberculosis drugs administered as part of clinical care in p…
Hamid M, Brooks MB, Madhani F, Ali H, Naseer MJ, et al.
Objective Pakistan has a high pediatric burden of tuberculosis, but few studies describe the treatment experience of children with tuberculosis in Pakistan. We sought to identify risk factors for unsuccessful treatment outcomes in children with drug-susceptible tuberculosis ident…
Fry S, Barnabas S, Cotton MF
Purpose of review Although tuberculosis (TB) causes much morbidity and mortality in children, diagnosis and treatment remain challenging. Recently, children have gained increasing attention in research and clinical trials driving improved contact management, case identification a…
Finlayson H, Lishman J, Palmer M
Purpose of review The current review identifies recent advances in the prevention, diagnosis, and treatment of childhood tuberculosis (TB) with a focus on the WHO's updated TB management guidelines released in 2022. Recent findings The COVID-19 pandemic negatively affected global…
Brittney Sweetser, Esin Nkereuwem, Jascent Nakafeero, Marie Gomez, Peter Wambi, et al.
**BACKGROUND:** Children with non-severe TB may benefit from short-course treatment, but point-of-care tools are needed to stratify disease severity. We prospectively evaluated the Cepheid Xpert MTB-Host Response (HR) prototype cartridge for distinguishing TB severity in children…