Showing 1–25 of 144 documents
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Goscé L, Bitencourt J, Gupta RK, Arruda S, Rodrigues LC, et al.
…e of implementing different preventive strategies alongside treatment of TB disease, including BCG vaccination and treatment of latent tuberculosis infection (LTBI). Large-scale population level LTBI treatment is not currently part of WHO guidelines which recommend LTBI treatment…
Brett K, Dulong C, Severn M
… (i.e., coughing). There are two distinct categories of TB, latent TB infection (LTBI) and active TB disease (also known as active TB)., A person with LTBI is not contagious as they cannot spread the bacteria to others and do not possess any visible symptoms. However, persons wit…
Brett K, Severn M
…ult in active TB disease, producing instead an asymptomatic latent TB infection. People with latent TB cannot spread the disease to others, but they can develop active TB disease. Symptoms of active TB disease include a bad cough, fever, and weight loss. The current treatment for…
Kerrigan D, Tudor C, Motlhaoleng K, Lebina L, Qomfu C, et al.
…est, Quantiferon-TB Gold In-Tube Test (QGIT), to screen for latent TB compared to the Tuberculin Screening Test (TST) among PLHIV in South Africa. Methods Fifty-six qualitative interviews were conducted with PLHIV and clinical providers participating in the TEKO trial. We explore…
Young C, Severn M
… 554 per 100,000 population. There are two stages to TB: 1) latent TB infection, and 2) active TB infection. Latent TB typically occurs immediately following exposure to the bacteria. Although an individual who has latent TB infection will not exhibit any symptoms and they are no…
Torres T, Brembilla NC, Langley RG, Warren RB, Thaçi D, et al.
…unocompetent individuals, the microorganism can remain in a latent, non-contagious form, however, it may become active under conditions of immunosuppression. Tumour necrosis factor (TNF) inhibitors, which are frequently used for the management of immune-mediated disorders like ps…
Medrano BA, Lee M, Gemeinhardt G, Rodríguez-Herrera JE, García-Viveros M, et al.
…ght to identify host factors associated with TB and adverse treatment outcomes in older Hispanics by conducting a cross-sectional study of TB surveillance data from Tamaulipas, Mexico (2006-2013; n = 8381). Multivariable logistic regressions were assessed for older adults (OA ≥65…
Duret A, Thorley E, Eni-Olotu A, Sikdar O, Papineni P
…on with HBV or HCV can lead to an increased risk of adverse treatment outcomes, such as drug-induced liver injury (DILI) in patients with active or latent TB. National guidelines recommend routinely screening for HBV/HCV prior to initiating TB treatment. Our objectives were to 1)…
Kuscu F, Yildirim F, Erturk D, Cabalak M, Komur S, et al.
Background About 10% of individuals with latent tuberculosis infection (LTBI) develop tuberculosis (TB) disease during their lifetime. People living with HIV (PLWH) have a significantly higher risk of developing tuberculosis disease from latent tuberculosis infection (LTBI) compa…
Basu S, Sharma N, Mase S, Sachdeva KS
…enge of effective management to minimise the progression of latent TB infection (LTBI) to TB, thereby interrupting the chain of transmission. Approximately 5%-10% LTBI cases eventually develop TB in their lifetime with the risk being higher in children, people living with HIV/AID…
Ren B, Bai X, Zhang H, Sun L, Fang L, et al.
…sis (TB), and about 90% of those infected have asymptomatic latent infections. It has been reported that 85-90% of newly diagnosed active TB cases evolve from patients with latent tuberculosis infection (LTBI). In approximately 5-10% of patients, LTBI progresses to active TB duri…
Bar-Meir M, Pariente G, Romem A, Wiener-Well Y
Objective Official guidelines recommend tuberculosis (TB) screening programmes for all healthcare workers (HCWs), along with offering treatment when latent TB infection (LTBI) is diagnosed. However, adherence to treatment among HCWs is lower compared with non-HCWs. The aim of the…
Dobler CC, Bosnic-Anticevich S, Armour CL
…was to explore the views of tuberculosis (TB) physicians on treatment of latent TB infection (LTBI), focusing on decision making and communication in clinical practice. 20 Australian TB physicians participated in a semistructured interview in person or over the telephone. Intervi…
O'Connell J, Oguntuase J, McConkey S, de Barra E
…on It is estimated that 24.8% of the world's population has latent TB. The World Health Organization's (WHO) End TB Strategy states that the systematic identification and management of LTBI in groups of people at high risk of reactivation is an essential part of TB elimination in…
Bedingfield N, Barss L, Oxlade O, Menzies D, Fisher D
Setting Identification, assessment, and treatment of latent TB infection (LTBI), collectively known as the LTBI cascade of care, is critical for TB prevention. Objective The objective of this research, conducted within the ACT4 trial, was to assess and strengthen the LTBI cascade…
Kampmann B, Seddon JA, Paton J, Nademi Z, Keane D, et al.
…ays (IGRA) to the tuberculin skin test (TST) in its 2006 TB guidelines. Treatment for TB infection was no longer recommended for children who screened TST-positive but IGRA-negative. Objectives We performed a cohort study to evaluate the risk of TB disease in this group. Methods …
Brett K, Dulong C, Severn M
…xtrapulmonary TB). Individuals with TB are categorized into latent TB infection (LTBI) and active TB disease., LTBI refers to an individual whom does not have TB disease and may not possess any symptoms but has the M. tuberculosis infection. Persons with LTBI cannot spread TB inf…
Medrano BA, Lee M, Gemeinhardt G, Yamba L, Restrepo BI
…mycobacteria (although less lung cavitations) in OA. During treatment, OA had less drug-resistant TB, few adverse reactions and adhered with TB treatment. We recommend training healthcare workers to 'think TB' in OA, for prompt treatment initiation to diminish deaths. Furthermore…
Mehtani NJ, Puryear S, Pham P, Dooley KE, Shah M
…e with human immunodeficiency virus (PWH). The diagnosis of latent TB infection (LTBI) and treatment with TB preventative therapy (TPT) can reduce morbidity and mortality in this population. Historically, isoniazid has been recommended for TPT in PWH due to the absence of drug-dr…
Winter JR, Stagg HR, Smith CJ, Lalor MK, Davidson JA, et al.
Background HIV increases the progression of latent tuberculosis (TB) infection to active disease and contributed to increased TB in the UK until 2004. We describe temporal trends in HIV infection amongst patients with TB and identify factors associated with HIV infection. Methods…
Yoopetch P, Anothaisintawee T, Gunasekara ADM, Jittikoon J, Udomsinprasert W, et al.
…f three network meta-analyses (NMA) examining the efficacy, treatment completion, and adverse events associated with all latent tuberculosis infection (LTBI) treatments, there is currently no evidence to support the notion that the benefits of these treatments outweigh the potent…
Marks SM, Self JL, Venkatappa T, Wolff MB, Hopkins PB, et al.
…tion and control among PEH. Our goal was to provide current guidelines and information in one place to inform medical and public health providers and TB programs on TB incidence, diagnosis, and treatment among PEH. Methods We reviewed and synthesized diagnostic and treatment reco…
Burguet L, Duvignaud A, Nguyen D, Receveur MC, Kaminski H, et al.
…rding to their level of priority. In those with evidence of latent TB infection, treatment decision was based on the level of exposure, individual vulnerability, as well as the results of an interferon-gamma release assay. Results A total of 130 patients with CKD and 180 KTR were…
O'Connell J, de Barra E, McNally C, McConkey S
Aim Knowledge of latent tuberculosis infection (LTBI) screening and treatment practices are lacking in Ireland, where LTBI is not programmatically surveyed or managed. The aim of this research was to describe current clinical practice when screening and treating patients for LTBI…
Hashim Z, Tyagi R, Singh GV, Nath A, Kant S
…prevention of the development of active disease by treating latent TB infection (LTBI). The guidelines for the same were already provided by the WHO and were then adapted in the Indian guidelines for the treatment of LTBI in 2021. While the long-term impact of TBI treatment is aw…